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Cough and Arabinogalactan Polysaccharide from the Bark of Terminalia Arjuna

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Pulmonary Infection and Inflammation

Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 935))

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Abstract

In this work we investigated the antitussive activity of the medicinal tree Terminalia arjuna. We used the stem bark for extraction and preparation of water extracted isolate and its two fractions: acetone-soluble (TA-S) and acetone precipitated (TA-P) fraction. The presence of a pectic arabinogalactan was confirmed in TA-P fraction by chromatographic and spectroscopic analysis. The antitussive activity of samples was assessed after oral administration in a dose of 50 mg.kg−1 in healthy guinea pigs, in which cough was elicited by inhalation of citric acid (0.3 mol/L) in body plethysmograph. The water extracted isolate showed a significant ability to decrease the number of cough efforts by 64.2 %; the antitussive activity on par with that of codeine phosphate. The TA-P fraction showed the antitussive activity of 54.8 %. In contrast, TA-S fraction had only a mild antitussive activity. No changes in in vivo airway resistance were noted. We conclude that arabinogalactan is an essential component of Terminalia arjuna that underlies its antitussive action.

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Acknowledgements

Supported by grants: UK/148/2015, MZ 2012/35-UKMA-12, APVV-0305-12 and BioMed Martin ITMS 26220220187.

Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

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Authors and Affiliations

  1. Comenius University in Bratislava, Biomedical Center Martin and Department of Pharmacology, Jessenius Faculty of Medicine in Martin, 4C Mala Hora, 03 601, Martin, Slovakia

    V. Sivová & G. Nosáľová

  2. Natural Products Laboratory, Department of Chemistry, University of Burdwan, Bardhaman, West Bengal, India

    K. Bera & B. Ray

  3. Clinic of Anesthesiology and Intensive Medicine, Jessenius Faculty of Medicine, Martin University Hospital, Martin, Slovakia

    S. Nosáľ

Authors
  1. V. Sivová
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  2. K. Bera
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  3. B. Ray
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  4. S. Nosáľ
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  5. G. Nosáľová
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Corresponding author

Correspondence to V. Sivová .

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Editors and Affiliations

  1. Public Higher Medical Professional School in Opole, Institute of Nursing, Opole, Poland

    Mieczyslaw Pokorski

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Sivová, V., Bera, K., Ray, B., Nosáľ, S., Nosáľová, G. (2016). Cough and Arabinogalactan Polysaccharide from the Bark of Terminalia Arjuna . In: Pokorski, M. (eds) Pulmonary Infection and Inflammation. Advances in Experimental Medicine and Biology(), vol 935. Springer, Cham. https://doi.org/10.1007/5584_2016_30

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