Abstract
Chromium is a well-known mutagen and carcinogen involved in lung cancer development. DNA repair genes play an important role in the elimination of genetic changes caused by chromium exposure. In the present study, we investigated the polymorphisms of the following DNA repair genes: XRCC3, participating in the homologous recombination repair, and hMLH1 and hMSH2, functioning in the mismatch repair. We focused on the risk the polymorphisms present in the development of lung cancer regarding the exposure to chromium. We analyzed 106 individuals; 45 patients exposed to chromium with diagnosed lung cancer and 61 healthy controls. Genotypes were determined by a PCR-RFLP method. We unravelled a potential for increased risk of lung cancer development in the hMLH1 (rs1800734) AA genotype in the recessive model. In conclusion, gene polymorphisms in the DNA repair genes underscores the risk of lung cancer development in chromium exposed individuals.
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References
Adamkov M, Kajo K, Výbohová D, Krajčovič J, Štuller F, Rajčáni J (2012) Correlations of survivin expression with clinicomorphological parameters and hormonal receptor status in breast ductal carcinoma. Neoplasma 59(1):30–37
Bei L, Xiao-Dong T, Yu-Fang G, Jian-Ping S, Zhao-Yu Y (2015) DNA repair gene XRCC3 Thr241Met polymorphisms and lung cancer risk: a meta-analysis. Bull Cancer 102(4):332–339
Bray FJ, Weiderpass E (2010) Lung cancer mortality trends in 36 European countries: secular trends and birth cohort patterns by sex and region 1970–2007. Int J Cancer 126(6):1454–1466
Chen HJ, Chang WS, Hsia TC, Miao CE, Chen WC, Liang SJ, Chen AC, Chang JG, Tsai CW, Hsu CM, Tsai CH, Bau DT (2015) Contribution of genotype of DNA double-strand break repair gene XRCC3, gender, and smoking behavior to lung cancer risk in Taiwan. Anticancer Res 35(7):3893–3899
Dai H, Liu J, Malkas LH, Catalano J, Alagharu S, Hickey RJ (2009) Chromium reduces the in vitro activity and fidelity of DNA replication mediated by the human cell DNA synthesome. Toxicol Appl Pharmacol 236(2):154–165
Geng H, Hsieh P (eds) (2013). Molecular mechanisms and functions of DNA mismatch repair. DNA Alterations in Lynch Syndrome. Springer, Chapter 2, pp 25–45
Halasova E, Baska T, Kukura F, Mazurova D, Bukovska E, Dobrota D, Poliacek I, Halasa M (2005) Lung cancer in relation to occupational and environmental chromium exposure and smoking. Neoplasma 52(4):287–291
Huang HH, Huang JY, Lung C, Wu CL, Ho C, Hua Sun YH, Ko PC, Su SY, Chen SC, Yung-Po Liaw YP (2013) Cell-type specificity of lung cancer associated with low-dose soil heavy metal contamination in Taiwan: an ecological study. BMC Public Health 2(13):330–336
Huvinen M, Pukkala E (2013) Cancer incidence among Finnish ferrochromium and stainless steel production workers in 1967–2011: a cohort study. BMJ Open 3(11):e003819
IARC (1990) International agency for research on cancer. IARC monographs on the evaluation of carcinogenic risks to humans. Vol 49: Chromium nickel and welding, Geneva, Switzerland pp 49–256
Iyer RR, Pluciennik A, Burdett V, Modrich PL (2006) DNA mismatch repair: functions and mechanisms. Chem Rev 106(2):302–323
Kubrak OI, Lushchak OV, Lushchak JV, Torous IM, Storey JM, Storey KB, Lushchak VI (2010) Chromium effects on free radical processes in goldfish tissues: comparison of Cr (III) and Cr (VI) exposures on oxidative stress markers, glutathione status and antioxidant enzymes. Comp Biochem Physiol C Toxicol Pharmacol 152(3):360–370
Kunkel TA, Erie DA (2005) DNA mismatch repair. Annu Rev Biochem 74:681–710
Li GM (2008) Mechanisms and functions of DNA mismatch repair. Cell Res 18:85–98
Li M, Zhang Q, Liu L, Lu W, Wei H, Li RW, Lu S (2013) Expression of the mismatch repair gene hMLH1 is enhanced in non-small cell lung cancer with EGFR mutations. PLoS One 8(10), e78500
Mandal RK, Gangwar R, Kapoor R, Mittal RD (2012) Polymorphisms in base-excision repair genes and prostate cancer risk in north Indian population. Indian J Med Res 135(1):64–71
Pal T, Permuth-Wey J, Sellers TA (2008) A review of the clinical relevance of mismatch-repair deficiency in ovarian cancer. Cancer 113(4):733–742
Salah GB, Fendri-Kria N, Hassen Kamoun H, Kallab F, Mkaouar-Rebai E, Amine Fourati A, Ayadi H, Fakhfakh F (2012) An interethnic variability and a functional prediction of DNA repair gene polymorphisms: the example of XRCC3 (p.Thr241 > Met) and XPD (p.Lys751 > Gln) in a healthy Tunisian population. Mol Biol Rep 39:9639–9647
Slovakova P, Majerova L, Matakova T, Skerenova M, Kavcova E, Halasova E (2015) Mismatch repair gene polymorphisms and association with lung cancer development. Adv Exp Med Biol 833:15–22
Vageli DP, Zaravinos A, Daniil Z, Dahabreh J, Doukas SG, Spandidos DA, Gourgoulianis KI, Koukoulis GK (2013) hMSH2 and hMLH1 gene expression patterns differ between lung adenocarcinoma and squamous cell carcinoma: correlation with patient survival and response to adjuvant chemotherapy treatment. Int J Biol Markers 27(4):e400–e404
Velma V, Tchounwou PB (2010) Chromium-induced biochemical, genotoxic and histopathologic effects in liver and kidney of goldfish, Carassius auratus. Mutat Res 698(1–2):43–51
Xing ZS, Zhu G, Yang YL, Feng GQ, Ding GC (2014) Meta analysis of XRCC3 Thr241Met polymorphism and lung cancer susceptibility of populations in East Asia. Asian Pac J Trop Med 7(6):483–487
Zhang XH, Zhang X, Wang XC, Jin LF, Yang ZP, Jiang CX, Chen Q, Ren XB, Cao JZ, Wang Q (2011) Chronic occupational exposure to hexavalent chromium causes DNA damage in electroplating workers. BMC Public Health 11(1):224
Zhang JH, Wen QL, Yang C, Li AL, Lium Y, Li XS (2014) XRCC3 T241M polymorphism and lung cancer risk in the Han Chinese population: a meta-analysis. Genet Mol Res 13(4):9505–9513
Zmetakova I, Danihel L, Smolkova B, Mego M, Kajabova V, Krivulcik T, Rusnak I, Rychly B, Danis D, Repiska V, Blasko P, Karaba M, Benca J, Pechan J, Fridrichova I (2013) Evaluation of protein expression and DNA methylation profiles detected by pyrosequencing in invasive breast cancer. Neoplasma 60(6):635–646
Acknowledgements
This work was supported by the Ministry of Health of the Slovak Republic Grants 2012/25-UKMA-2, APVV-0412-11, and VEGA 1/0336/12.
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The authors declare no conflicts of interest in relation to this article.
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Halasova, E. et al. (2016). Polymorphisms of Selected DNA Repair Genes and Lung Cancer in Chromium Exposure. In: Pokorski, M. (eds) Advances in Respiratory Cancerogenesis. Advances in Experimental Medicine and Biology(), vol 911. Springer, Cham. https://doi.org/10.1007/5584_2016_218
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DOI: https://doi.org/10.1007/5584_2016_218
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