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Mechanisms of Bacterial Colonization of Implants and Host Response

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A Modern Approach to Biofilm-Related Orthopaedic Implant Infections

Part of the book series: Advances in Experimental Medicine and Biology ((AMIDPH,volume 971))

Abstract

The review focuses on the current knowledge and the most pertinent hypotheses regarding the local host immune response as the key factor for the pathogenesis of implant-associated infections. Although bacterial biofilms have long been recognized as causative agents, the link between the infection and the devastating inflammatory response, particularly the localized tissue destruction and bone degradation is less well understood. Understanding these consequences of infection, however, is of utmost importance, because suppressing inflammation and preventing bone destruction could be a novel, alternative therapeutic option in cases when eradicating the infections fails.

The authors state that there is no actual or potential conflict of interest regarding the study.

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Authors and Affiliations

  1. Zentrum für Orthopädie und Unfallchirurgie, Klinikum Ingolstadt, Krumenauerstraße 25, 85049, Ingolstadt, Germany

    Christof Wagner

  2. Institut für Immunologie der Universität Heidelberg, Im Neuenheimer Feld 305, 69120, Heidelberg, Germany

    G. Maria Hänsch

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  2. G. Maria Hänsch
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Correspondence to Christof Wagner .

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Editors and Affiliations

  1. Department of Biomedical Sciences Health, University of Milan, Milan, Italy

    Lorenzo Drago

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Wagner, C., Hänsch, G.M. (2016). Mechanisms of Bacterial Colonization of Implants and Host Response. In: Drago, L. (eds) A Modern Approach to Biofilm-Related Orthopaedic Implant Infections. Advances in Experimental Medicine and Biology(), vol 971. Springer, Cham. https://doi.org/10.1007/5584_2016_173

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