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Algorithm to Diagnose Delayed and Late PJI: Role of Joint Aspiration

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Part of the book series: Advances in Experimental Medicine and Biology ((AMIDPH,volume 971))

Abstract

Total Joint Arthroplasty (TJA) continues to gain acceptance as the standard of care for the treatment of severe degenerative joint disease, and is considered one of the most successful surgical interventions in the history of medicine. A devastating complication after TJA is infection. Periprosthetic joint infection (PJI), represents one of the major causes of failure and remains a significant challenge facing orthopaedics today. PJI usually requires additional surgery including revision of the implants, fusion or amputations causing tremendous patient suffering but also a heavy health economics burden. PJI is at the origin of around 20–25 % of total knee arthroplasty (Bozic et al. 2010; de Gorter et al. 2015; Sundberg et al. 2015) and 12–15 % of total hip arthroplasty (Bozic et al. 2009; Garellick et al. 2014; de Gorter et al. 2015) failures.

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References

  • Aebischer D, Ferrando M, Hasgall P, Rieker C. Synovasure PJI. Lateral flow diagnostic test: results from a multi-center multi-surgeon clinical survey:1–16. 16A.D

    Google Scholar 

  • Aggarwal VK, Tischler E, Ghanem E, Parvizi J (2013) Leukocyte esterase from synovial fluid aspirate: a technical note. J Arthroplasty 28:193–195

    Article  PubMed  Google Scholar 

  • Berbari E, Mabry T, Tsaras G, Spangehl M, Erwin PJ, Murad MH, Steckelberg J, Osmon D (2010) Inflammatory blood laboratory levels as markers of prosthetic joint infection: a systematic review and meta-analysis. J Bone Joint Surg Am 92:2102–2109

    Article  PubMed  Google Scholar 

  • Bingham J (2014) The alpha defensin-1 biomarker assay can be used to evaluate the potentially infected total joint arthroplasty

    Google Scholar 

  • Bonanzinga T, Zahar A, Dutsch M, Lausmann C, Kendoff D, Gehrke T (2016) How reliable is the alpha-defensin immunoassay test for diagnosing periprosthetic joint infection? A prospective study. Clin Orthop Relat Res

    Google Scholar 

  • Bottner F, Wegner A, Winkelmann W, Becker K, Erren M, Gotze C (2007) Interleukin-6, procalcitonin and TNF-alpha: markers of peri-prosthetic infection following total joint replacement. J Bone Joint Surg (Br) 89:94–99

    Article  CAS  Google Scholar 

  • Bozic KJ, Kurtz SM, Lau E, Ong K, Vail TP, Berry DJ (2009) The epidemiology of revision total hip arthroplasty in the United States. J Bone Joint Surg Am 91:128–133

    Article  PubMed  Google Scholar 

  • Bozic KJ, Kurtz SM, Lau E, Ong K, Chiu V, Vail TP, Rubash HE, Berry DJ (2010) The epidemiology of revision total knee arthroplasty in the United States. Clin Orthop Relat Res 468:45–51

    Article  PubMed  Google Scholar 

  • Bozic KJ, Ward DT, Lau EC, Chan V, Wetters NG, Naziri Q, Odum S, Fehring TK, Mont MA, Gioe TJ, Della Valle CJ (2014) Risk factors for periprosthetic joint infection following primary total hip arthroplasty: a case control study. J Arthroplasty 29:154–156

    Article  PubMed  Google Scholar 

  • Brook M, Tomlinson GH, Miles K, Smith RW, Rossi AG, Hiemstra PS, Van’t Wout EF, Dean JL, Gray NK, Lu W, Gray M (2016) Neutrophil-derived alpha defensins control inflammation by inhibiting macrophage mRNA translation. Proc Natl Acad Sci U S A 113:4350–4355

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • CD diagnostics (2013) A new paradigm for the diagnosis of periprosthethic joint infection [White Paper]:1–29

    Google Scholar 

  • de Gorter JJ, Green M, Gregg P, Porter M, Price A, Tucker K, Wilkinson M, Wishart N (2015) 12th annual report 2015, National Joint Registry for England, Wales and Northern Ireland

    Google Scholar 

  • De Vecchi VE, Villa F, Bortolin M, Toscano M, Tacchini L, Romano CL, Drago L (2016) Leucocyte esterase, glucose and C-reactive protein in the diagnosis of prosthetic joint infections: a prospective study. Clin Microbiol Infect 22:555–560

    Article  PubMed  Google Scholar 

  • Deirmengian C, Lonner JH, Booth RE Jr (2005) The Mark Coventry Award: white blood cell gene expression: a new approach toward the study and diagnosis of infection. Clin Orthop Relat Res 440:38–44

    Article  PubMed  Google Scholar 

  • Deirmengian C, Hallab N, Tarabishy A, Della VC, Jacobs JJ, Lonner J, Booth RE Jr (2010) Synovial fluid biomarkers for periprosthetic infection. Clin Orthop Relat Res 468:2017–2023

    Article  PubMed  PubMed Central  Google Scholar 

  • Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J (2014a) Combined measurement of synovial fluid alpha-Defensin and C-reactive protein levels: highly accurate for diagnosing periprosthetic joint infection. J Bone Joint Surg Am 96:1439–1445

    Article  PubMed  Google Scholar 

  • Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Parvizi J (2014b) Diagnosing periprosthetic joint infection: has the era of the biomarker arrived? Clin Orthop Relat Res 472:3254–3262

    Article  PubMed  PubMed Central  Google Scholar 

  • Deirmengian C, Kardos K, Kilmartin P, Cameron A, Schiller K, Booth RE, Parvizi J (2015) The alpha-defensin test for periprosthetic joint infection outperforms the leukocyte esterase test strip. Clin Orthop Relat Res 473:198–203

    Article  PubMed  Google Scholar 

  • Del Pozo JL, Patel R (2009) Clinical practice. Infection associated with prosthetic joints. N Engl J Med 361:787–794

    Article  PubMed  PubMed Central  Google Scholar 

  • Dinneen A, Guyot A, Clements J, Bradley N (2013) Synovial fluid white cell and differential count in the diagnosis or exclusion of prosthetic joint infection. Bone Joint J 95-B:554–557

    Article  CAS  PubMed  Google Scholar 

  • Drago L, Lidgren L, Bottinelli E, Villafane JH, Berjano P, Banfi G, Romano CL, Sculco TP (2016) Mapping of microbiological procedures by the members of the International Society of Orthopaedic Centers (ISOC) for diagnosis of periprosthetic infections. J Clin Microbiol 54:1402–1403

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Frangiamore SJ, Saleh A, Grosso MJ, Kovac MF, Higuera CA, Iannotti JP, Ricchetti ET (2015) Alpha-Defensin as a predictor of periprosthetic shoulder infection. J Shoulder Elbow Surg 24:1021–1027

    Article  PubMed  Google Scholar 

  • Frangiamore SJ, Gajewski ND, Saleh A, Farias-Kovac M, Barsoum WK, Higuera CA (2016) Alpha-defensin accuracy to diagnose periprosthetic joint infection-best available test? J Arthroplasty 31:456–460

    Article  PubMed  Google Scholar 

  • Ganz T, Selsted ME, Szklarek D, Harwig SS, Daher K, Bainton DF, Lehrer RI (1985) Defensins. Natural peptide antibiotics of human neutrophils. J Clin Invest 76:1427–1435

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Garellick G, Kärrholm J, Lindahl H, Malchau H, Rogmark C, Rolfson O (2014) The Swedish hip arthroplasty register, annual report 2014

    Google Scholar 

  • Ghanem E, Parvizi J, Burnett RS, Sharkey PF, Keshavarzi N, Aggarwal A, Barrack RL (2008) Cell count and differential of aspirated fluid in the diagnosis of infection at the site of total knee arthroplasty. J Bone Joint Surg Am 90:1637–1643

    Article  PubMed  Google Scholar 

  • Gollwitzer H, Dombrowski Y, Prodinger PM, Peric M, Summer B, Hapfelmeier A, Saldamli B, Pankow F, von Eisenhart-Rothe R, Imhoff AB, Schauber J, Thomas P, Burgkart R, Banke IJ (2013) Antimicrobial peptides and proinflammatory cytokines in periprosthetic joint infection. J Bone Joint Surg Am 95:644–651

    Article  PubMed  Google Scholar 

  • Hughes JG, Vetter EA, Patel R, Schleck CD, Harmsen S, Turgeant LT, Cockerill FR III (2001) Culture with BACTEC Peds Plus/F bottle compared with conventional methods for detection of bacteria in synovial fluid. J Clin Microbiol 39:4468–4471

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jacovides CL, Parvizi J, Adeli B, Jung KA (2011) Molecular markers for diagnosis of periprosthetic joint infection. J Arthroplasty 26:99–103

    Article  PubMed  Google Scholar 

  • Kasparek MF, Kasparek M, Boettner F, Faschingbauer M, Hahne J, Dominkus M (2016) Intraoperative diagnosis of periprosthetic joint infection using a novel alpha-defensin lateral flow assay. J Arthroplasty

    Google Scholar 

  • Kersey R, Benjamin J, Marson B (2000) White blood cell counts and differential in synovial fluid of aseptically failed total knee arthroplasty. J Arthroplasty 15:301–304

    Article  CAS  PubMed  Google Scholar 

  • Kurtz SM, Lau E, Schmier J, Ong KL, Zhao K, Parvizi J (2008) Infection burden for hip and knee arthroplasty in the United States. J Arthroplasty 23:984–991

    Article  PubMed  Google Scholar 

  • Lehrer RI, Ganz T (1992) Defensins: endogenous antibiotic peptides from human leukocytes. Ciba Found Symp 171:276–290

    CAS  PubMed  Google Scholar 

  • Parvizi J, Azzam K, Ghanem E, Austin MS, Rothman RH (2009) Periprosthetic infection due to resistant staphylococci: serious problems on the horizon. Clin Orthop Relat Res 467:1732–1739

    Article  PubMed  PubMed Central  Google Scholar 

  • Parvizi J, Jacovides C, Antoci V, Ghanem E (2011a) Diagnosis of periprosthetic joint infection: the utility of a simple yet unappreciated enzyme. J Bone Joint Surg Am 93:2242–2248

    Article  PubMed  Google Scholar 

  • Parvizi J, Zmistowski B, Berbari EF, Bauer TW, Springer BD, Della Valle CJ, Garvin KL, Mont MA, Wongworawat MD, Zalavras CG (2011b) New definition for periprosthetic joint infection: from the Workgroup of the Musculoskeletal Infection Society. Clin Orthop Relat Res 469:2992–2994

    Article  PubMed  PubMed Central  Google Scholar 

  • Parvizi J, Gehrke T, Chen AF (2013) Proceedings of the international consensus on periprosthetic joint infection. Bone Joint J 95-B:1450–1452

    Article  CAS  PubMed  Google Scholar 

  • Qu X, Zhai Z, Wu C, Jin F, Li H, Wang L, Liu G, Liu X, Wang W, Li H, Zhang X, Zhu Z, Dai K (2013) Preoperative aspiration culture for preoperative diagnosis of infection in total hip or knee arthroplasty. J Clin Microbiol 51:3830–3834

    Article  PubMed  PubMed Central  Google Scholar 

  • Qu X, Zhai Z, Liu X, Li H, Wu C, Li Y, Li H, Zhu Z, Qin A, Dai K (2014) Evaluation of white cell count and differential in synovial fluid for diagnosing infections after total hip or knee arthroplasty. PLoS One 9:e84751

    Article  PubMed  PubMed Central  Google Scholar 

  • Schinsky MF, Della Valle CJ, Sporer SM, Paprosky WG (2008) Perioperative testing for joint infection in patients undergoing revision total hip arthroplasty. J Bone Joint Surg Am 90:1869–1875

    Article  PubMed  Google Scholar 

  • Sia IG, Berbari EF, Karchmer AW (2005) Prosthetic joint infections. Infect Dis Clin North Am 19:885–914

    Article  PubMed  Google Scholar 

  • Sundberg M, Lidgren L, Dahl AN, Robertsson O (2015) Swedish knee arthroplasty register, annual report 2015

    Google Scholar 

  • Tischler EH, Plummer DR, Chen AF, Della Valle CJ, Parvizi J (2016) Leukocyte esterase: metal-on-metal failure and periprosthetic joint infection. J Arthroplasty

    Google Scholar 

  • Trampuz A, Zimmerli W (2005) Prosthetic joint infections: update in diagnosis and treatment. Swiss Med Wkly 135:243–251

    PubMed  Google Scholar 

  • Trampuz A, Hanssen AD, Osmon DR, Mandrekar J, Steckelberg JM, Patel R (2004) Synovial fluid leukocyte count and differential for the diagnosis of prosthetic knee infection. Am J Med 117:556–562

    Article  PubMed  Google Scholar 

  • Vegari D (2013) Predisposing factors for periprosthetic joint infection. In: Parvizi J (ed) Periprosthetic joint infection: practical management guide. Jaypee Brothers Medical Publishers, New Delhi, pp 59–63

    Google Scholar 

  • Wetters NG, Berend KR, Lombardi AV, Morris MJ, Tucker TL, Della Valle CJ (2012) Leukocyte esterase reagent strips for the rapid diagnosis of periprosthetic joint infection. J Arthroplasty 27:8–11

    Article  PubMed  Google Scholar 

  • Wirtz DC, Heller KD, Miltner O, Zilkens KW, Wolff JM (2000) Interleukin-6: a potential inflammatory marker after total joint replacement. Int Orthop 24:194–196

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Wu C, Qu X, Liu F, Li H, Mao Y, Zhu Z (2014) Risk factors for periprosthetic joint infection after total hip arthroplasty and total knee arthroplasty in Chinese patients. PLoS One 9:e95300

    Article  PubMed  PubMed Central  Google Scholar 

  • Zimmerli W (2006) Infection and musculoskeletal conditions: prosthetic-joint-associated infections. Best Pract Res Clin Rheumatol 20:1045–1063

    Article  PubMed  Google Scholar 

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Correspondence to Olivier Borens .

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© 2016 Springer International Publishing Switzerland

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Borens, O., Corona, P.S., Frommelt, L., Lazarinis, S., Reed, M.R., Romano, C.L. (2016). Algorithm to Diagnose Delayed and Late PJI: Role of Joint Aspiration. In: Drago, L. (eds) A Modern Approach to Biofilm-Related Orthopaedic Implant Infections. Advances in Experimental Medicine and Biology(), vol 971. Springer, Cham. https://doi.org/10.1007/5584_2016_153

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