Abstract
Portal vein thrombosis is a life-threatening vascular disorder of the liver. In this chapter, I will review the recent advance regarding the epidemiology, etiology, management, and prognosis of portal vein thrombosis.
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Ageno W, Dentali F, De Stefano V et al (2014) Clonal populations of hematopoietic cells with paroxysmal nocturnal hemoglobinuria phenotype in patients with splanchnic vein thrombosis. Thromb Res 133:1052–1055
Ahluwalia J, Naseem S, Sachdeva MU et al (2014) Paroxysmal Nocturnal Hemoglobinuria is rare cause for thrombosis of the intra-abdominal veins in the ethnic Indian population – results from FLAER-based flowcytometry screening. Eur J Haematol 92:435–443
Amitrano L, Guardascione MA, Menchise A et al (2010) Safety and efficacy of anticoagulation therapy with low molecular weight heparin for portal vein thrombosis in patients with liver cirrhosis. J Clin Gastroenterol 44:448–451
Bizollon T, Bissuel F, Detry L, Trepo C (1991) Fibrinolytic therapy for portal vein thrombosis. Lancet 337:1416
Cao G, Ko GY, Sung KB, Yoon HK, Gwon DI, Kim JH (2013) Treatment of postoperative main portal vein and superior mesenteric vein thrombosis with balloon angioplasty and/or stent placement. Acta Radiol 54:526–532
Chen VT, Wei J, Liu YC (1992) A new procedure for management of extrahepatic portal obstruction. Proximal splenic-left intrahepatic portal shunt. Arch Surg 127:1358–1360
Chung JW, Kim GH, Lee JH et al (2014) Safety, efficacy, and response predictors of anticoagulation for the treatment of nonmalignant portal-vein thrombosis in patients with cirrhosis: a propensity score matching analysis. Clin Mol Hepatol 20:384–391
Condat B, Pessione F, Denninger MH, Hillaire S, Valla D (2000) Recent portal or mesenteric venous thrombosis: increased recognition and frequent recanalization on anticoagulant therapy. Hepatology 32:466–470
Condat B, Pessione F, Hillaire S et al (2001) Current outcome of portal vein thrombosis in adults: risk and benefit of anticoagulant therapy. Gastroenterology 120:490–497
de Franchis R (2010) Revising consensus in portal hypertension: report of the Baveno V consensus workshop on methodology of diagnosis and therapy in portal hypertension. J Hepatol 53:762–768
De Santis A, Moscatelli R, Catalano C et al (2010) Systemic thrombolysis of portal vein thrombosis in cirrhotic patients: a pilot study. Dig Liver Dis 42:451–455
De Stefano V, Martinelli I (2010) Splanchnic vein thrombosis: clinical presentation, risk factors and treatment. Intern Emerg Med 5:487–494
de Ville de Goyet J, Clapuyt P, Otte JB (1992) Extrahilar mesenterico-left portal shunt to relieve extrahepatic portal hypertension after partial liver transplant. Transplantation 53:231–232
DeLeve LD, Valla DC, Garcia-Tsao G (2009) Vascular disorders of the liver. Hepatology 49:1729–1764
Delgado MG, Seijo S, Yepes I et al (2012) Efficacy and safety of anticoagulation on patients with cirrhosis and portal vein thrombosis. Clin Gastroenterol Hepatol 10:776–783
di Francesco F, Grimaldi C, de Ville de Goyet J (2014) Meso-Rex bypass – a procedure to cure prehepatic portal hypertension: the insight and the inside. J Am Coll Surg 218:e23–e36
Fimognari FL, Violi F (2008) Portal vein thrombosis in liver cirrhosis. Intern Emerg Med 3:213–218
Girleanu I, Stanciu C, Cojocariu C, Boiculese L, Singeap AM, Trifan A (2014) Natural course of nonmalignant partial portal vein thrombosis in cirrhotic patients. Saudi J Gastroenterol 20:288–292
Guerin F, Bidault V, Gonzales E, Franchi-Abella S, De Lambert G, Branchereau S (2013) Meso-Rex bypass for extrahepatic portal vein obstruction in children. Br J Surg 100:1606–1613
Janssen HL, Wijnhoud A, Haagsma EB et al (2001) Extrahepatic portal vein thrombosis: aetiology and determinants of survival. Gut 49:720–724
Lautz TB, Keys LA, Melvin JC, Ito J, Superina RA (2013) Advantages of the meso-Rex bypass compared with portosystemic shunts in the management of extrahepatic portal vein obstruction in children. J Am Coll Surg 216:83–89
Luca A, Caruso S, Milazzo M et al (2012) Natural course of extrahepatic nonmalignant partial portal vein thrombosis in patients with cirrhosis. Radiology 265:124–132
Maruyama H, Ishibashi H, Takahashi M, Shimada T, Kamesaki H, Yokosuka O (2012) Prediction of the therapeutic effects of anticoagulation for recent portal vein thrombosis: a novel approach with contrast-enhanced ultrasound. Abdom Imaging 37:431–438
Nery F, Chevret S, Condat B et al (2015) Causes and consequences of portal vein thrombosis in 1,243 patients with cirrhosis: results of a longitudinal study. Hepatology 61:660–667
Ogren M, Bergqvist D, Bjorck M, Acosta S, Eriksson H, Sternby NH (2006) Portal vein thrombosis: prevalence, patient characteristics and lifetime risk: a population study based on 23,796 consecutive autopsies. World J Gastroenterol 12:2115–2119
Plessier A, Darwish-Murad S, Hernandez-Guerra M et al (2010) Acute portal vein thrombosis unrelated to cirrhosis: a prospective multicenter follow-up study. Hepatology 51:210–218
Qi X, Han G (2012) Transjugular intrahepatic portosystemic shunt in the treatment of portal vein thrombosis: a critical review of literature. Hepatol Int 6:576–590
Qi X, Han G, Fan D (2010) The preferable treatment for cirrhotic portal vein thrombosis: anticoagulation or transjugular intrahepatic portosystemic shunt? Hepatology 51:713–714
Qi X, Bai M, Yang Z et al (2011) Occlusive portal vein thrombosis as a new marker of decompensated cirrhosis. Med Hypotheses 76:522–526
Qi X, Zhang C, Han G et al (2012) Prevalence of the JAK2V617F mutation in Chinese patients with Budd-Chiari syndrome and portal vein thrombosis: a prospective study. J Gastroenterol Hepatol 27:1036–1043
Qi X, De Stefano V, Wang J et al (2013a) Prevalence of inherited antithrombin, protein C, and protein S deficiencies in portal vein system thrombosis and Budd-Chiari syndrome: a systematic review and meta-analysis of observational studies. J Gastroenterol Hepatol 28:432–442
Qi X, He C, Han G et al (2013b) Prevalence of paroxysmal nocturnal hemoglobinuria in Chinese patients with Budd-Chiari syndrome or portal vein thrombosis. J Gastroenterol Hepatol 28:148–152
Qi X, Chen H, Han G (2013c) Effect of antithrombin, protein C and protein S on portal vein thrombosis in liver cirrhosis: a meta-analysis. Am J Med Sci 346:38–44
Qi XS, Bai M, He CY et al (2013d) Prognostic factors in non-malignant and non-cirrhotic patients with portal cavernoma: an 8-year retrospective single-center study. World J Gastroenterol 19:7447–7454
Qi X, Ren W, De Stefano V, Fan D (2014a) Associations of coagulation factor V Leiden and prothrombin G20210A mutations with Budd-Chiari syndrome and portal vein thrombosis: a systematic review and meta-analysis. Clin Gastroenterol Hepatol 12:1801–1812 e7
Qi X, Yang Z, De Stefano V, Fan D (2014b) Methylenetetrahydrofolate reductase C677T gene mutation and hyperhomocysteinemia in Budd-Chiari syndrome and portal vein thrombosis: a systematic review and meta-analysis of observational studies. Hepatol Res 44:E480–E498
Qi X, Bai M, Guo X, Fan D (2014c) Pharmacologic prophylaxis of portal venous system thrombosis after splenectomy: a meta-analysis. Gastroenterol Res Pract 2014:292689
Qi X, Yang Z, Fan D (2014d) Spontaneous resolution of portal vein thrombosis in cirrhosis: where do we stand, and where will we go? Saudi J Gastroenterol 20:265–266
Qi X, Wu F, He C, Fan D, Han G (2015a) Thrombotic risk factors in Chinese nonmalignant and noncirrhotic patients with portal vein thrombosis: an observational study with a systematic review of the literature. Eur J Gastroenterol Hepatol 27:77–83
Qi X, De Stefano V, Su C, Bai M, Guo X, Fan D (2015b) Associations of antiphospholipid antibodies with splanchnic vein thrombosis: a systematic review with meta-analysis. Medicine (Baltimore) 94:e496
Qi X, De Stefano V, Li H, Dai J, Guo X, Fan D (2015c) Anticoagulation for the treatment of portal vein thrombosis in liver cirrhosis: a systematic review and meta-analysis of observational studies. Eur J Intern Med 26:23–29
Rajani R, Bjornsson E, Bergquist A et al (2010) The epidemiology and clinical features of portal vein thrombosis: a multicentre study. Aliment Pharmacol Ther 32:1154–1162
Robin P, Gruel Y, Lang M, Lagarrigue F, Scotto JM (1988) Complete thrombolysis of mesenteric vein occlusion with recombinant tissue-type plasminogen activator. Lancet 1:1391
Rossle M (2013) TIPS: 25 years later. J Hepatol 59:1081–1093
Silva-Junior G, Turon F, Hernandez-Gea V, Darnell A, Garcia-Criado A, Garcia-Pagan JC (2014) Unexpected disappearance of portal cavernoma on long-term anticoagulation. J Hepatol 61:446–448
Smalberg JH, Spaander MV, Jie KS et al (2008) Risks and benefits of transcatheter thrombolytic therapy in patients with splanchnic venous thrombosis. Thromb Haemost 100:1084–1088
Smalberg JH, Arends LR, Valla DC, Kiladjian JJ, Janssen HL, Leebeek FW (2012) Myeloproliferative neoplasms in Budd-Chiari syndrome and portal vein thrombosis: a meta-analysis. Blood 120:4921–4928
Spaander MC, van Buuren HR, Hansen BE, Janssen HL (2010) Ascites in patients with noncirrhotic nonmalignant extrahepatic portal vein thrombosis. Aliment Pharmacol Ther 32:529–534
Spaander MC, Hoekstra J, Hansen BE, Van Buuren HR, Leebeek FW, Janssen HL (2013) Anticoagulant therapy in patients with non-cirrhotic portal vein thrombosis: effect on new thrombotic events and gastrointestinal bleeding. J Thromb Haemost 11:452–459
Tripodi A, Mannucci PM (2011) The coagulopathy of chronic liver disease. N Engl J Med 365:147–156
Tripodi A, Primignani M, Chantarangkul V et al (2009) An imbalance of pro- vs anti-coagulation factors in plasma from patients with cirrhosis. Gastroenterology 137:2105–2111
Villa E, Camma C, Marietta M et al (2012) Enoxaparin prevents portal vein thrombosis and liver decompensation in patients with advanced cirrhosis. Gastroenterology 143:1253–1260
Wang MQ, Guo LP, Lin HY, Liu FY, Duan F, Wang ZJ (2010) Transradial approach for transcatheter selective superior mesenteric artery urokinase infusion therapy in patients with acute extensive portal and superior mesenteric vein thrombosis. Cardiovasc Intervent Radiol 33:80–89
Wang MQ, Liu FY, Duan F, Wang ZJ, Song P, Fan QS (2011) Acute symptomatic mesenteric venous thrombosis: treatment by catheter-directed thrombolysis with transjugular intrahepatic route. Abdom Imaging 36:390–398
Wang J, Yang W, Huang Q et al (2015) Interventional treatment for portal venous occlusion after liver transplantation: long-term follow-up results. Medicine (Baltimore) 94:e356
Zhu K, Meng X, Zhou B et al (2013) Percutaneous transsplenic portal vein catheterization: technical procedures, safety, and clinical applications. J Vasc Interv Radiol 24:518–527
Ziakas PD, Poulou LS, Rokas GI, Bartzoudis D, Voulgarelis M (2007) Thrombosis in paroxysmal nocturnal hemoglobinuria: sites, risks, outcome. An overview. J Thromb Haemost 5:642–645
Zocco MA, Di Stasio E, De Cristofaro R et al (2009) Thrombotic risk factors in patients with liver cirrhosis: correlation with MELD scoring system and portal vein thrombosis development. J Hepatol 51:682–689
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Qi, X. (2016). Portal Vein Thrombosis: Recent Advance. In: Islam, M. (eds) Thrombosis and Embolism: from Research to Clinical Practice. Advances in Experimental Medicine and Biology(), vol 906. Springer, Cham. https://doi.org/10.1007/5584_2016_118
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DOI: https://doi.org/10.1007/5584_2016_118
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