Quorum Quenching Strategy Targeting Gram-Positive Pathogenic Bacteria

  • Ravindra Pal Singh
  • Said E. Desouky
  • Jiro NakayamaEmail author
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 901)


Quorum sensing (QS) is a cell density-dependent regulatory system that orchestrates the group behavior of unicellular organisms by synchronizing the expression of certain gene(s) within the clonal community of same species. Bacterial pathogens often employ QS system to establish efficiently an infection. A large part of low GC Gram-positive bacteria belonging to phylum Firmicutes use thiolactone/lactone peptides as communication signals so-called autoinducing peptides (AIPs) to coordinate QS circuit. In particular, QS of staphylococci, enterococci, and clostridia have been intensively studied in terms of alternative target of anti-pathogenic chemotherapy independent of bactericidal antibiotics. Thus far, a number of quorum quenching (QQ) agents that targeting the QS circuit of these Gram-positive pathogens have been developed by random screening of natural compounds or rationale design of AIP antagonists. This review summarizes those QQ agents and previews their potential as post-antibiotic drugs.


Quorum sensing (QS) Quorum quenching (QQ) Autoinducing peptide (AIP) Gram-positive bacteria 



This research was supported in part by a Grant-in-Aid for Scientific Research No. 24380050 and 15H04480 for J. Nakayama and a Grant-in-Aid for JSPS Fellows No. 25–03389 for R. P. Singh. R. P. Singh is also gratefully acknowledging JSPS for providing the Post Doctoral Fellowship.


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Copyright information

© Springer International Publishing Switzerland 2016

Authors and Affiliations

  • Ravindra Pal Singh
    • 1
  • Said E. Desouky
    • 1
    • 2
  • Jiro Nakayama
    • 1
    Email author
  1. 1.Laboratory of Microbial Technology, Department of Bioscience and Biotechnology, Faculty of Agriculture, Graduate SchoolKyushu UniversityFukuokaJapan
  2. 2.Department of Botany and Microbiology, Faculty of ScienceAl-Azhar UniversityNasr CityEgypt

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