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The Role of Human Herpesvirus 8 in Diabetes Mellitus Type 2: State of the Art and a Medical Hypothesis

  • Raffaello PompeiEmail author
Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 901)

Abstract

Diabetes is a common chronic disease due to an altered glucose metabolism, caused by the quantitative and/or qualitative dysfunction of the insulin hormone. Two types of diabetes are recognized: juvenile diabetes, or type 1, which has an autoimmune origin, and adult diabetes, or type 2 (DMT2), which covers 90–95 % of all diabetic patients.

The causes of DMT2 are not yet clear: heredity, life style, nutrition, and environment are considered the main risk factors. Several viral infections, namely cytomegalovirus, coxsackie and other enteroviruses, rubella and hepatitis C virus, have been claimed to be associated with some forms of diabetes. The direct role of viruses as a cause or as a risk of type 1 diabetes has been amply described in several recent reviews. Therefore, this review focuses attention on the role of a human herpes pathogenic virus in the onset of DMT2. By carrying out an analysis of recent literature, we describe the findings reported on an extremely deceitful virus, such as Human Herpes virus 8, and present a medical hypothesis on a possible relationship between this virus and DMT2.

Keywords

Human Herpesvirus 8 Diabetes type 2 Latent virus infection Insulin resistance 

Notes

Acknowledgements

The authors appreciate the collaboration of Ms Sally Davies for manuscript preparation and correction. The grant for this work was funded by the Fondazione Banco di Sardegna 2014–2015.

Conflict of Interest

The author declares no conflict of interest.

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Copyright information

© Springer International Publishing Switzerland 2015

Authors and Affiliations

  1. 1.Department of Biomedical SciencesUniversity of CagliariCagliariItaly

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