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Increase in Peripheral CD3−CD56brightCD16− Natural Killer Cells in Hashimoto’s Thyroiditis Associated with HHV-6 Infection

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Advances in Microbiology, Infectious Diseases and Public Health

Part of the book series: Advances in Experimental Medicine and Biology ((AMIDPH,volume 897))

Abstract

Hashimoto’s thyroiditis (HT) is a very common autoimmune disease of the thyroid. In addition to genetic background, several viruses, including herpesviruses, have been suggested to play a role as possible environmental triggers of disease, but conclusive data are still lacking. Previous results showed that HT patients have an increased cellular immune response directed against the HHV-6 U94 protein and increased NK activity directed against HHV-6 infected thyrocytes.

In this study, we characterized the antiviral antibody response and the NK cells activity and subtype in HHV-6 infected HT patients. The results showed that HT subjects have increased prevalence and titer of anti-U94 antibodies and a higher amount of CD3-CD56brightCD16−NK cell percentages compared to controls. Furthermore, the cell activation of CD3−CD56bright NK cells in HT patients significantly correlates with TPO and Tg Ab levels.

The results suggest that HHV-6 might contribute to HT development, increasing NK cell secretion of inflammatory cytokines that could sustain the persistence of an inflammatory status in HT patients.

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Acknowledgements

This work was supported by grants from University of Ferrara (FAR).

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Authors and Affiliations

  1. Department of Medical Sciences – Section of Microbiology and Medical Genetics, University of Ferrara, Via Luigi Borsari, 46, 44121, Ferrara, Italy

    Roberta Rizzo, Antonella Rotola, Enzo Cassai, Dario Di Luca & Elisabetta Caselli

  2. Section of Endocrinology and Internal Medicine, Department of Medical Sciences, University of Ferrara, Ferrara, Italy

    Maria Chiara Zatelli & Ettore Degli Uberti

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  1. Roberta Rizzo
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  2. Maria Chiara Zatelli
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  3. Antonella Rotola
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  4. Enzo Cassai
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  5. Ettore Degli Uberti
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  6. Dario Di Luca
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  7. Elisabetta Caselli
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Correspondence to Dario Di Luca .

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  1. Microbial Biofilm Laboratory, Fondazione Santa Lucia IRCCS, Rome, Italy

    Gianfranco Donelli

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Rizzo, R. et al. (2015). Increase in Peripheral CD3−CD56brightCD16− Natural Killer Cells in Hashimoto’s Thyroiditis Associated with HHV-6 Infection. In: Donelli, G. (eds) Advances in Microbiology, Infectious Diseases and Public Health. Advances in Experimental Medicine and Biology(), vol 897. Springer, Cham. https://doi.org/10.1007/5584_2015_5010

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