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Regulatory T Cells in Obesity

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Noncommunicable Diseases

Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 866))

Abstract

The current concept of the pathogenesis of obesity relates to the inflammation caused by excess of adipose tissue. Regulatory T cells accumulated in visceral adipose tissue (VAT-resident Tregs) are also involved in this pathogenesis. In the present paper the mechanisms responsible for alterations in the number and function of VAT-resident Tregs T in obesity are described. The role of Tregs in inflammation, insulin resistance, atherogenesis, and also the influence on VAT-resident Tregs of adipocytokines and insulin are reviewed.

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Conflicts of Interest

The authors declare no conflicts of interest in relation to this article.

Author information

Authors and Affiliations

  1. Department of Pediatrics and Endocrinology, Medical University of Warsaw, 24 Marszalkowska St., 00-576, Warsaw, Poland

    Anna M. Kucharska & Beata Pyrżak

  2. Department of Laboratory Diagnostics and Clinical Immunology of the Developmental Age, Medical University of Warsaw, Warsaw, Poland

    Urszula Demkow

Authors
  1. Anna M. Kucharska
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  2. Beata Pyrżak
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  3. Urszula Demkow
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Corresponding author

Correspondence to Anna M. Kucharska .

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Editors and Affiliations

  1. Institute of Nursing, Public Higher Medical Professional School in Opole, Opole, Poland

    Mieczyslaw Pokorski

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Kucharska, A.M., Pyrżak, B., Demkow, U. (2015). Regulatory T Cells in Obesity. In: Pokorski, M. (eds) Noncommunicable Diseases. Advances in Experimental Medicine and Biology(), vol 866. Springer, Cham. https://doi.org/10.1007/5584_2015_147

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