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Polymorphisms of DNA Repair Genes and Lung Cancer in Chromium Exposure

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Lung Cancer and Autoimmune Disorders

Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 833))

Abstract

Chromium is a well known carcinogen involved in the lung cancer development. Polymorphism of some of the DNA repair genes may be associated with elevated risk of cancerous transformation. In the present study, we investigated the polymorphisms of the following selected members of the base and nucleotide excision repair genes: XPC (Lys939Gln), XPD (Lys751Gln), XRCC1(Arg399Gln), and hOGG1(Ser326Ser), and the risk they present toward the development of lung cancer, with emphasis on the effect of chromium exposure. We analyzed 119 individuals; 50 patients exposed to chromium with diagnosed lung cancer and 69 healthy controls. Genotypes were determined by a PCR-RFLP method. We found a significantly increased risk of lung cancer development in XPD genotype Lys/Gln (OR = 1.94; 95 % CI = 1.10–3.43; p = 0.015) and in the gene combinations: XPD Lys/Gln+XPC Lys/Gln (OR = 6.5; 95 % CI = 1.53–27.49; p = 0.009) and XPD Lys/Gln+XPC Gln/Gln(OR = 5.2; 95 % CI = 1.07–25.32; p = 0.04). In conclusion, gene polymorphisms in the DNA repair genes may underscore the risk of lung cancer development in the chromium-exposed individuals.

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Acknowledgements

This work was supported by the project ‘Competence Center for Research and Development in the Field of Diagnostics and Therapy of Oncological Diseases, ITMS26220220153, co-funded from the EU sources and the European Regional Development Fund and by the grants of the Slovak Research and Developmental Agency under the contract APVV-0412-11 and the Ministry of Heath of the Slovak Republic under the contract MZ 2012/25-UKMA-2.

Conflicts of Interest

The authors reported no conflicts of interest in relation to this article.

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Authors and Affiliations

  1. Department of Medical Biochemistry, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, 4 Malá Hora St., 036 01, Martin, Slovakia

    M. Sarlinova & T. Matakova

  2. Department of Medical Biology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia

    L. Majerova, P. Slovakova & E. Halašová

  3. Clinic of Occupational Medicine and Toxicology, Comenius University in Bratislava, Jessenius Faculty of Medicine in Martin and University Hospital in Martin, Martin, Slovakia

    L. Musak

  4. Department of Clinical Biochemistry, University Hospital in Martin, Martin, Slovakia

    M. Škereňová

  5. Clinic of Pneumology and Phthisiology, Jessenius Faculty of Medicine in Martin, Comenius University in Bratislava, Martin, Slovakia

    E. Kavcová

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  1. M. Sarlinova
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  2. L. Majerova
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Correspondence to E. Halašová .

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  1. Institute of Psychology, Opole University, Poland

    Mieczyslaw Pokorski

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Sarlinova, M. et al. (2014). Polymorphisms of DNA Repair Genes and Lung Cancer in Chromium Exposure. In: Pokorski, M. (eds) Lung Cancer and Autoimmune Disorders. Advances in Experimental Medicine and Biology(), vol 833. Springer, Cham. https://doi.org/10.1007/5584_2014_82

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