Abstract
Copeptin has been associated with the severity of pneumonia and its complications. This study was designed to assess the usefulness of copeptin measurement in children with community-acquired pneumonia (CAP) and copeptin’s relation with disease severity and sodium equilibrium. The study encompassed 311 patients (227 with pneumonia and 84 healthy controls) aged 8 days–18 years. Clinical findings and inflammatory markers were used to predict the disease severity. We found that the level of copeptin was significantly higher in patients with CAP (median 0.88 ng/mL) vs. healthy children (0.33 ng/mL; p < 0.01). ROC analysis showed a high AUC value (0.87) and the cut-off point for plasma copeptin level was 0.44 ng/mL, with a high sensitivity (89 %) and specificity (73 %) in recognizing pneumonia. Patients with higher copeptin concentrations were at higher risk of hyponatremia (OR 2.43). Yet there was only a weak reverse correlation between the sodium and the copeptin concentrations (Spearmann’s rank coefficient = −0.19). The levels of copeptin were higher in hyponatremic patients (0.83 ng/mL) vs. normonatremic patients (0.69 ng/mL; p = 0.02). Copeptin elevation did not reflect the CAP severity measured with traditionally used methods. In conclusion, copeptin elevation is a promising marker of pneumonia, but it reflects neither the disease severity nor sodium concentration.
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Supported by the Medical Center of Postgraduate Education in Warsaw grant number 506-1-20-01-13.
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The authors declare no conflicts of interest in relation to this article.
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Wrotek, A., Jackowska, T., Pawlik, K. (2014). Sodium and Copeptin Levels in Children with Community Acquired Pneumonia. In: Pokorski, M. (eds) Respiratory Infections. Advances in Experimental Medicine and Biology(), vol 835. Springer, Cham. https://doi.org/10.1007/5584_2014_41
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DOI: https://doi.org/10.1007/5584_2014_41
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