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Nocturnal Parasympathetic Modulation of Heart Rate in Obesity-Hypoventilation Patients

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Oxidative Stress and Cardiorespiratory Function

Part of the book series: Advances in Experimental Medicine and Biology ((NR,volume 832))

Abstract

Heart rate variation (HRV) reflects the activity of the autonomic nervous system. The aim of the study was to analyze HRV in obstructive sleep apnea (OSA) and obesity hypoventilation (OH) patients to answer the question of whether chronic alveolar hypoventilation influences autonomic heart rate regulation. In 41 patients, diagnosed with either ‘pure’ OSA (n = 23, apnea/hypopnea index – AHI: 43.8 ± 18.0 PaCO2 ≤ 45 mmHg) or OH syndrome (n = 18, AHI 58.7 ± 38.0 PaCO2 > 46 mmHg), the HRV was analyzed, based on an 8 h ECG recording during sleep. In the OH patients, compared with the OSA patients, there was a globally decreased HRV, with a corresponding decrease in high frequency power in the spectral analysis of HRV and increased low frequency/high frequency ratio (p < 0.05), indicating a reduced parasympathetic and increased sympathetic heart rate modulation. We conclude that hypoxemia and hypercapnia of the sleep disordered breathing have an impact on the autonomic heart rate regulation. HRV indices have a potential to become prognostic factors for the development of cardiovascular complications in patients with sleep disordered breathing.

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Conflicts of Interest

The authors declare no conflict of interest in relation to this article.

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Authors and Affiliations

  1. Department of Pneumology and Lung Cancer, Wroclaw Medical University, 105 Grabiszynska St., 53-439, Wroclaw, Poland

    A. Brzecka, P. Piesiak & R. Jankowska

  2. Iserian Center of Pneumology and Chemotherapy, Szklarska Poreba, Poland

    M. Pawelec-Winiarz

  3. Department of Internal Medicine, Fourth Military Clinical Hospital, Wroclaw, Poland

    A. Teplicki

Authors
  1. A. Brzecka
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  2. M. Pawelec-Winiarz
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  3. A. Teplicki
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  4. P. Piesiak
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  5. R. Jankowska
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Corresponding author

Correspondence to A. Brzecka .

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Editors and Affiliations

  1. Institute of Psychology, Opole University, Poland

    Mieczyslaw Pokorski

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© 2014 Springer International Publishing Switzerland

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Brzecka, A., Pawelec-Winiarz, M., Teplicki, A., Piesiak, P., Jankowska, R. (2014). Nocturnal Parasympathetic Modulation of Heart Rate in Obesity-Hypoventilation Patients. In: Pokorski, M. (eds) Oxidative Stress and Cardiorespiratory Function. Advances in Experimental Medicine and Biology(), vol 832. Springer, Cham. https://doi.org/10.1007/5584_2014_3

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