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Electrochemical Nanocavity Devices

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Label-Free Biosensing

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 16))

Abstract

Nanocavity sensors comprise one or several sensing elements within a highly confined channel or gap, typically produced by microfabrication technology. Depending on the specific design and implementation, such devices can offer several benefits for the detection of molecules or cellular signals. This chapter describes fundamental aspects of nanocavity sensors as well as state-of-the-art fabrication and research applications. In the first part of the chapter, we introduce single-electrode nanocavity devices and highlight their application for the capacitive sensing of extracellular voltage signals. Next, we discuss several implementations of multi-electrode nanocavity devices, which are used for electrochemical detection of molecules. These devices exhibit very high sensitivities due to the amplification of signals by redox cycling within the confined space of the nanocavity. We highlight recent approaches for using multi-electrode cavity sensors and sensor arrays for biosensing applications. Finally, we present novel fabrication approaches that allow cost-effective rapid prototyping of nanocavity devices.

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References

  1. Anderson LB, Reilley CN (1965) J Electroanal Chem 10(1959):295

    CAS  Google Scholar 

  2. Oglesby DM, Omang SH, Reilley CN (1965) Anal Chem 37:1312

    Article  CAS  Google Scholar 

  3. Anderson LB, Reilley CN (1959) J Electroanal Chem 10:538

    Google Scholar 

  4. Liu HY, Fan FRF, Lin CW, Bard AJ (1986) J Am Chem Soc 108:3838

    Article  CAS  Google Scholar 

  5. Bard AJ, Fan FR, Kwak J, Lev O (1989) Anal Chem 61:132

    Article  CAS  Google Scholar 

  6. Sanderson DG, Anderson LB (1985) Anal Chem 57:2388

    Article  CAS  Google Scholar 

  7. Niwa O, Morita M, Tabei H (1990) Anal Chem 62:447

    Article  CAS  Google Scholar 

  8. Fan F-RF, Bard AJ (1995) Science 267:871

    Article  CAS  PubMed  Google Scholar 

  9. Sun P, Mirkin MV (2008) J Am Chem Soc 130:8241

    Article  CAS  PubMed  Google Scholar 

  10. Zevenbergen MAG, Singh PS, Goluch ED, Wolfrum BL, Lemay SG (2011) Nano Lett 11:2881

    Article  CAS  PubMed  Google Scholar 

  11. Singh PS, Kätelhön E, Mathwig K, Wolfrum B, Lemay SG (2012) ACS Nano 6:9662

    Article  CAS  PubMed  Google Scholar 

  12. Lemay SG, Kang S, Mathwig K, Singh PS (2013) Acc Chem Res 46:369

    Article  CAS  PubMed  Google Scholar 

  13. Hofmann B, Kätelhön E, Schottdorf M, Offenhäusser A, Wolfrum B (2011) Lab Chip 11:1054

    Article  CAS  PubMed  Google Scholar 

  14. Thomas CA, Springer PA, Loeb GE, Berwald-Netter Y, Okun LM (1972) Exp Cell Res 74:61

    Article  PubMed  Google Scholar 

  15. Rutten WLC (2002) Annu Rev Biomed Eng 4:407

    Article  CAS  PubMed  Google Scholar 

  16. Pine J (1980) J Neurosci Methods 2:19

    Article  CAS  PubMed  Google Scholar 

  17. Cogan SF (2008) Annu Rev Biomed Eng 10:275

    Article  CAS  PubMed  Google Scholar 

  18. Xie C, Lin Z, Hanson L, Cui Y, Cui B (2012) Nat Nanotechnol 7:185

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Spira ME, Hai A (2013) Nat Nanotechnol 8:83

    Article  CAS  PubMed  Google Scholar 

  20. Santoro F, Dasgupta S, Schnitker J, Auth T, Neumann E, Panaitov G, Gompper G, Offenhäusser A (2014) ACS Nano 8:6713

    Article  CAS  PubMed  Google Scholar 

  21. VanDersarl JJ, Renaud P (2016) Sci Rep 6:32485

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Kim J-H, Kang G, Nam Y, Choi Y-K (2010) Nanotechnology 21:085303

    Article  CAS  Google Scholar 

  23. Brüggemann D, Wolfrum B, Maybeck V, Mourzina Y, Jansen M, Offenhäusser A (2011) Nanotechnology 22:265104

    Article  CAS  PubMed  Google Scholar 

  24. Nick C, Quednau S, Sarwar R, Schlaak HF, Thielemann C (2014) Microsyst Technol 20:1849

    Article  CAS  Google Scholar 

  25. Gabay T, Ben-David M, Kalifa I, Sorkin R, Abrams ZR, Ben-Jacob E, Hanein Y (2007) Nanotechnology 18:035201

    Article  CAS  PubMed  Google Scholar 

  26. Shoval A, Adams C, David-Pur M, Shein M, Hanein Y, Sernagor E (2009) Front Neuroeng 2:4

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Greenbaum A, Anava S, Ayali A, Shein M, David-Pur M, Ben-Jacob E, Hanein Y (2009) J Neurosci Methods 182:219

    Article  PubMed  Google Scholar 

  28. Heim M, Yvert B, Kuhn A (2012) J Physiol Paris 106:137

    Article  PubMed  Google Scholar 

  29. David-Pur M, Bareket-Keren L, Beit-Yaakov G, Raz-Prag D, Hanein Y (2014) Biomed Microdevices 16:43

    Article  CAS  PubMed  Google Scholar 

  30. Seker E, Berdichevsky Y, Begley MR, Reed ML, Staley KJ, Yarmush ML (2010) Nanotechnology 21:125504

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Urbanová V, Li Y, Vytřas K, Yvert B, Kuhn A (2011) J Electroanal Chem 656:91

    Article  CAS  Google Scholar 

  32. Berdondini L, Imfeld K, Maccione A, Tedesco M, Neukom S, Koudelka-Hep M, Martinoia S (2009) Lab Chip 9:2644

    Article  CAS  PubMed  Google Scholar 

  33. Bakkum DJ, Frey U, Radivojevic M, Russell TL, Müller J, Fiscella M, Takahashi H, Hierlemann A (2013) Nat Commun 4:2181

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Bertotti G, Velychko D, Dodel N, Keil S, Wolansky D, Tillak B, Schreiter M, Grall A, Jesinger P, Röhler S, Eickenscheidt M, Stett A, Möller A, Boven KH, Zeck G, Thewes R (2014) In: 2014 I.E. biomedical circuits and systems conference (BioCAS) proceedings, pp 304–307

    Google Scholar 

  35. Ballini M, Müller J, Livi P, Chen Y, Frey U, Stettler A, Shadmani A, Viswam V, Jones IL, Jäckel D, Radivojevic M, Lewandowska MK, Gong W, Fiscella M, Bakkum DJ, Heer F, Hierlemann A (2014) IEEE J Solid State Circuits 49:2705

    Article  PubMed  PubMed Central  Google Scholar 

  36. Müller J, Ballini M, Livi P, Chen Y, Radivojevic M, Shadmani A, Viswam V, Jones IL, Fiscella M, Diggelmann R, Stettler A, Frey U, Bakkum DJ, Hierlemann A (2015) Lab Chip 15:2767

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  37. Amin H, Maccione A, Marinaro F, Zordan S, Nieus T, Berdondini L (2016) Front Neurosci 10:121

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Fertig N, Blick RH, Behrends JC (2002) Biophys J 82:3056

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  39. Li X, Klemic KG, Reed MA, Sigworth FJ (2006) Nano Lett 6:815

    Article  CAS  PubMed  Google Scholar 

  40. Behrends J, Fertig N (2007) Planar patch clamping. In: Walz W (ed) Neuromethods. Humana Press, Totowa, pp 411–433

    Google Scholar 

  41. Schottdorf M, Hofmann B, Kätelhön E, Offenhäusser A, Wolfrum B (2012) Phys Rev E 85:031917

    Article  CAS  Google Scholar 

  42. Czeschik A, Rinklin P, Derra U, Ullmann S, Holik P, Steltenkamp S, Offenhäusser A, Wolfrum B (2015) Nanoscale 7:9275

    Article  CAS  PubMed  Google Scholar 

  43. Czeschik A, Offenhäusser A, Wolfrum B (2014) Phys Status Solidi A 211:1462

    Article  CAS  Google Scholar 

  44. Zevenbergen MAG, Krapf D, Zuiddam MR, Lemay SG (2007) Nano Lett 7:384

    Article  CAS  PubMed  Google Scholar 

  45. Wolfrum B, Zevenbergen M, Lemay S (2008) Anal Chem 80:972

    Article  CAS  PubMed  Google Scholar 

  46. Bard AJ, Fan F-RF (1996) Acc Chem Res 29:572

    Article  CAS  Google Scholar 

  47. Fan F-RF, Kwak J, Bard AJ (1996) J Am Chem Soc 118:9669

    Article  CAS  Google Scholar 

  48. Wightman RM, Jankowski JA, Kennedy RT, Kawagoe KT, Schroeder TJ, Leszczyszyn DJ, Near JA, Diliberto EJ, Viveros OH (1991) Proc Natl Acad Sci 88:10754

    Article  CAS  PubMed  Google Scholar 

  49. Amatore C, Arbault S, Guille M, Lemaître F (2008) Chem Rev 108:2585

    Article  CAS  PubMed  Google Scholar 

  50. Cans A-S, Ewing AG (2011) J Solid State Electrochem 15:1437

    Article  CAS  Google Scholar 

  51. Zafarani HR, Mathwig K, Lemay SG, Sudhölter EJR, Rassaei L (2016) ACS Sens 1:1439

    Article  CAS  Google Scholar 

  52. Kang S, Nieuwenhuis AF, Mathwig K, Mampallil D, Lemay SG (2013) ACS Nano 7:10931

    Article  CAS  PubMed  Google Scholar 

  53. Wolfrum B, Kätelhön E, Yakushenko A, Krause KJ, Adly N, Hüske M, Rinklin P (2016) Acc Chem Res 49:2031

    Article  CAS  PubMed  Google Scholar 

  54. Kang S, Mathwig K, Lemay SG (2012) Lab Chip 12:1262

    Article  CAS  PubMed  Google Scholar 

  55. Kätelhön E, Krause KJ, Mathwig K, Lemay SG, Wolfrum B (2014) ACS Nano 8:4924

    Article  CAS  PubMed  Google Scholar 

  56. Mampallil D, Mathwig K, Kang S, Lemay SG (2014) J Phys Chem Lett 5:636

    Article  CAS  PubMed  Google Scholar 

  57. Krause KJ, Mathwig K, Wolfrum B, Lemay SG (2014) Eur Phys J Spec Top 223:3165

    Article  Google Scholar 

  58. Mathwig K, Lemay SG (2013) Electrochim Acta 112:943

    Article  CAS  Google Scholar 

  59. Rassaei L, Mathwig K, Kang S, Heering HA, Lemay SG (2014) ACS Nano 8:8278

    Article  CAS  PubMed  Google Scholar 

  60. Kätelhön E, Hofmann B, Lemay SG, Zevenbergen MAG, Offenhäusser A, Wolfrum B (2010) Anal Chem 82:8502

    Article  CAS  PubMed  Google Scholar 

  61. Kätelhön E, Mayer D, Banzet M, Offenhäusser A, Wolfrum B, Beilstein J (2014) Nanotechnology 5:1137

    Google Scholar 

  62. Kanno Y, Ino K, Shiku H, Matsue T (2015) Lab Chip 15:4404

    Article  CAS  PubMed  Google Scholar 

  63. Hammond JL, Rosamond MC, Sivaraya S, Marken F, Estrela P (2016) Sensors 16:2128

    Article  CAS  Google Scholar 

  64. Zevenbergen MAG, Wolfrum BL, Goluch ED, Singh PS, Lemay SG (2009) J Am Chem Soc 131:11471

    Article  CAS  PubMed  Google Scholar 

  65. Xiong J, Chen Q, Edwards MA, White HS (2015) ACS Nano 9:8520

    Article  CAS  PubMed  Google Scholar 

  66. Chen Q, McKelvey K, Edwards MA, White HS (2016) J Phys Chem C 120:17251

    Article  CAS  Google Scholar 

  67. Rassaei L, Singh PS, Lemay SG (2011) Anal Chem 83:3974

    Article  CAS  PubMed  Google Scholar 

  68. Dawson K, O’Riordan A (2014) Annu Rev Anal Chem 7:163

    Article  CAS  Google Scholar 

  69. Lim Y, Heo J-I, Shin H (2014) Sens Actuators B 192:796

    Article  CAS  Google Scholar 

  70. Zafarani HR, Mathwig K, Sudhölter EJR, Rassaei L (2016) J Electroanal Chem 760:42

    Article  CAS  Google Scholar 

  71. Singh PS (2015) IEEE Access 3:249

    Article  Google Scholar 

  72. Dale SEC, Marken F (2013) Faraday Discuss 164:349

    Article  CAS  PubMed  Google Scholar 

  73. Hasnat MA, Gross AJ, Dale SEC, Barnes EO, Compton RG, Marken F (2014) Analyst 139:569

    Article  CAS  PubMed  Google Scholar 

  74. Lewis GEM, Dale SEC, Kasprzyk-Hordern B, Lubben AT, Barnes EO, Compton RG, Marken F (2014) Phys Chem Chem Phys 16:18966

    Article  CAS  PubMed  Google Scholar 

  75. Gross AJ, Marken F (2014) Electrochem Commun 46:120

    Article  CAS  Google Scholar 

  76. Montiel MA, Iniesta J, Gross AJ, Marken F (2017) Electrochim Acta 224:487

    Article  CAS  Google Scholar 

  77. Adly NY, Bachmann B, Krause KJ, Offenhäusser A, Wolfrum B, Yakushenko A (2017) RSC Adv 7:5473

    Article  CAS  Google Scholar 

  78. Ma C, Contento NM, Gibson LR, Bohn PW (2013) Anal Chem 85:9882

    Article  CAS  PubMed  Google Scholar 

  79. Hüske M, Stockmann R, Offenhäusser A, Wolfrum B (2013) Nanoscale 6:589

    Article  PubMed  Google Scholar 

  80. Zhu F, Yan J, Pang S, Zhou Y, Mao B, Oleinick A, Svir I, Amatore C (2014) Anal Chem 86:3138

    Article  CAS  PubMed  Google Scholar 

  81. Fu K, Han D, Ma C, Bohn PW (2016) Faraday Discuss 193:51

    Article  CAS  PubMed  Google Scholar 

  82. He D, Yan J, Zhu F, Zhou Y, Mao B, Oleinick A, Svir I, Amatore C (2016) Anal Chem 88:8535

    Article  CAS  PubMed  Google Scholar 

  83. Wang Y, Lin X, Su B (2016) Electrochem Commun 72:1

    Article  CAS  Google Scholar 

  84. Steentjes T, Sarkar S, Jonkheijm P, Lemay SG, Huskens J (2017) Small 13:1603268

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Neuroelectronics, Munich School of Bioengineering, Department of Electrical and Computer Engineering, Technical University of Munich, Boltzmannstraße 11, 85748, Garching, Germany

    Philipp Rinklin & Bernhard Wolfrum

  2. Institute of Bioelectronics (ICS-8/PGI-8), Forschungszentrum Jülich, Wilhelm-Johnen-Straße, 52425, Jülich, Germany

    Dirk Mayer & Bernhard Wolfrum

Authors
  1. Philipp Rinklin
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  2. Dirk Mayer
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  3. Bernhard Wolfrum
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Corresponding author

Correspondence to Bernhard Wolfrum .

Editor information

Editors and Affiliations

  1. Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Jülich, Germany

    Michael J. Schöning

  2. Institute of Nano- and Biotechnologies, Aachen University of Applied Sciences, Jülich, Germany

    Arshak Poghossian

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Rinklin, P., Mayer, D., Wolfrum, B. (2017). Electrochemical Nanocavity Devices. In: Schöning, M., Poghossian, A. (eds) Label-Free Biosensing. Springer Series on Chemical Sensors and Biosensors, vol 16. Springer, Cham. https://doi.org/10.1007/5346_2017_8

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