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Gold Nanostructure LSPR-Based Biosensors for Biomedical Diagnosis

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Book cover Applications of Nanomaterials in Sensors and Diagnostics

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 14))

Abstract

Progress in nanotechnology has enjoyed exponential growth in the past couple of decades. We have seen design and synthesis of metal nanoparticles (NPs) tailored specifically for biomedical diagnosis. In particular, noble metals have attracted lots of attention. Because of their unique optical and electronic properties, Au and Ag NPs have been exploited in the fabrication of localized surface plasmon resonance (LSPR) chips for detection of biomolecules. They impart increased sensitivity and also allow development of analytical platforms for label-free detection. These metal NPs show specific changes in their absorbance responses in the visible region of the spectrum upon binding with various molecules such as nucleic acids or proteins. In addition, the electronic properties, in particular, of Au and Ag NPs have been employed as labels for detection of proteins and other target molecules. In this chapter, we will focus on the use of Au NPs in LSPR-based biosensor technology. We will discuss the principles and applications of how these NPs have been and can be exploited for medical diagnostics by providing examples, mainly to the work we have conducted in our research group.

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Authors and Affiliations

  1. Japan Advanced Institute of Science and Technology, 1-1 Asahidai, Nomi City, Ishikawa, 923-1292, Japan

    Mun’delanji C. Vestergaard

  2. Department of Applied Physics, Graduate School of Engineering, Osaka University, Suita, Osaka, 565-0871, Japan

    Masato Saito, Hiroyuki Yoshikawa & Eiichi Tamiya

Authors
  1. Mun’delanji C. Vestergaard
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  2. Masato Saito
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  3. Hiroyuki Yoshikawa
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  4. Eiichi Tamiya
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Corresponding author

Correspondence to Eiichi Tamiya .

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Editors and Affiliations

  1. , Nanoelectronics and MEMS Laboratory, National Electronics and Computer Techno, Phahol Yothin Rd., Pathumthani, 12120, Thailand

    Adisorn Tuantranont

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Vestergaard, M.C., Saito, M., Yoshikawa, H., Tamiya, E. (2013). Gold Nanostructure LSPR-Based Biosensors for Biomedical Diagnosis. In: Tuantranont, A. (eds) Applications of Nanomaterials in Sensors and Diagnostics. Springer Series on Chemical Sensors and Biosensors, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/5346_2012_50

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