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Nanomaterial-Based Electroanalytical Biosensors for Cancer and Bone Disease

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Applications of Nanomaterials in Sensors and Diagnostics

Part of the book series: Springer Series on Chemical Sensors and Biosensors ((SSSENSORS,volume 14))

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Abstract

With recent advances in novel nanomaterial development, electroanalytical biosensors are undergoing a paradigm shift. New nanomaterial-based electrochemical biosensors can detect specific biomolecules at previously unattainable ultra-low concentrations. This chapter lists the existing biosensor technologies, describes the mechanisms, and applications of two types of electroanalytical biosensors, and then identifies the barriers in developing these biosensors and concludes by illustrating how nanomaterials can help overcome these limitations. A key feature of the electrochemical impedance sensor is that biomolecules detection can occur in real time without any pre-labeling. Specifically, this chapter summarizes the state of knowledge of the impedance sensor as applied in cancer and bone disease studies, which are clinically relevant.

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Acknowledgments

This research was partially supported by BAA11-001 Long Range Board Agency for Navy and Marine Corps Science and Technology Program, National Science Foundation, and the Korean Small and Medium Business Administration (Project no.00042172-1).

Author information

Authors and Affiliations

  1. Bioengineering, Engineering Research Center, North Carolina A & T State University, 1601 E. Market Street, Fort IRC, Room 119, Greensboro, NC, 27411, USA

    Yeoheung Yun

  2. Engineering Research Center, North Carolina A & T State University, Greensboro, NC, 27411, USA

    Boyce Collins, Yongseok Jang, Devdas Pai & Jag Sankar

  3. Internal Medicine, College of Medicine, University of Cincinnati, Cincinnati, OH, 45221, USA

    Zhongyun Dong

  4. Life Sciences, Applied BioPhysics, Inc., 185 Jordan Road, Troy, NY, 12180, USA

    Christen Renken

  5. Nanoworld and Smart Materials and Devices Laboratory, College of Engineering, University of Cincinnati, Cincinnati, OH, 45221, USA

    Mark Schulz

  6. Environmental Health, College of Medicine, University of Cincinnati, Cincinnati, OH, 45267, USA

    Amit Bhattacharya

  7. Bone Health and Osteoporosis Center, College of Medicine, University of Cincinnati, Cincinnati, OH, 45221, USA

    Nelson Watts

Authors
  1. Yeoheung Yun
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  2. Boyce Collins
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  3. Zhongyun Dong
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  4. Christen Renken
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  5. Mark Schulz
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  6. Amit Bhattacharya
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  7. Nelson Watts
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  8. Yongseok Jang
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  9. Devdas Pai
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  10. Jag Sankar
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Corresponding author

Correspondence to Yeoheung Yun .

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Editors and Affiliations

  1. , Nanoelectronics and MEMS Laboratory, National Electronics and Computer Techno, Phahol Yothin Rd., Pathumthani, 12120, Thailand

    Adisorn Tuantranont

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© 2012 Springer-Verlag Berlin Heidelberg

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Yun, Y. et al. (2012). Nanomaterial-Based Electroanalytical Biosensors for Cancer and Bone Disease. In: Tuantranont, A. (eds) Applications of Nanomaterials in Sensors and Diagnostics. Springer Series on Chemical Sensors and Biosensors, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/5346_2012_43

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