Abstract
Molecularly imprinted polymers are mostly confined to laboratories and their standardized environments. Chemical sensors based on MIP are no exception to this; however, there are increasing efforts to span the gap toward technological applications and thus exposing the devices to real-life environments and thereby assessing selectivity, sensitivity, and ruggedness of the respective sensors. In some application areas this has already been successful, namely in detecting volatile organics and their mixtures, sensing pesticides in environmental water samples, in assessing oxidation processes, e.g., in engine oils, and in some applications of bioanalysis targeting both signaling molecules/drugs and whole cells, viruses, or bacteria. Here, we summarize the selected aspects for transferring MIP strategies out from lab-bench conditions and highlight some of the successful examples.
Graphical Abstract
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Komiyama M, Takeuchi T, Mukawa T et al (2003) Molecular imprinting: from fundamentals to applications. Wiley-VCH, Weinheim
Alexander C, Andersson HS, Andersson LI et al (2006) Molecular imprinting science and technology: a survey of the literature for the years up to and including 2003. J Mol Recognit 19:106–180
Yan M, Ramström O (2005) Molecularly imprinted material-science and technology. Marcel Dekker, New York
Wulff G, Sarhan A (1972) Use of polymers with enzyme-analogous structures for the resolution of racemates. Angew Chem Int Ed Engl 11:341
Wulff G, Sarhan A, Zabrocki K et al (1973) Enzyme-analogue built polymers and their use for the resolution of racemates. Tetrahedron Lett 14:4329–4332
Arshady R, Mosbach K (1981) Synthesis of substrate-selective polymers by host–guest polymerization. Makromol Chem 182:687–692
Shea KJ, Dougherty TK (1986) Molecular recognition on synthetic amorphous surfaces: the influence of functional group positioning on the effectiveness of molecular recognition. J Am Chem Soc 108:1091–1093
Shea KJ, Sasaki DY (1989) On the control of microenvironment shape of functionalized network polymers prepared by template polymerization. J Am Chem Soc 111:3442–3444
Ramström O, Andersson LI, Mosbach K (1993) Recognition sites incorporating both pyridinyl and carboxy functionalities prepared by molecular imprinting. J Org Chem 58:7562–7564
Dickert FL, Hayden O (1999) Molecular imprinting in chemical sensing. Trends Anal Chem 18:192–198
Dickert FL, Lieberzeit PA, Achatz P et al (2004) QCM array for on-line-monitoring of composting procedures. Analyst 129:432–437
Piletsky SA, Alcock S, Turner AF (2001) Molecular imprinting: at the edge of the third millennium. Trends Biotechnol 19:9–12
Vlatakis G, Andersson LI, Muller R et al (1993) Drug assay using antibody mimics made by molecular imprinting. Nature 361:645–647
Haupt K, Mosbach K (1998) Plastic antibodies: developments and applications. Trends Biotechnol 16:468–478
Haupt K, Mosbach K (1999) Molecularly imprinted polymers in chemical and biological sensing. Biochem Soc Trans 27:344–350
Haupt K, Mosbach K (2000) Molecularly imprinted polymers and their use in biomimetic sensors. Chem Rev 100:2495–2504
Ramström O, Mosbach K (1999) Synthesis and catalysis by molecularly imprinted materials. Curr Opin Chem Biol 3:759–764
Wulff G (2002) Enzyme-like catalysis by molecularly imprinted polymers. Chem Rev 102:1–27
Dickert FL, Forth P, Fischerauer G et al (1998) SAW devices-sensitivity enhancement in going from 80 MHz to 1 GHz. Sens Actuators B Chem 46:120–125
di Natale C, Paolesse R, Macagnano A et al (2004) Sensitivity-selectivity balance in mass sensors: the case of metalloporphyrins. J Mater Chem 14:1281–1287
Dickert FL, Lieberzeit PA (2000) Solid-state sensors for field measurements of gases and vapours. In: Meyers RA (ed) Encyclopaedia of analytical chemistry. Wiley, Chichester, pp 3831–3855
Janata J (2010) Principles of chemical sensors. Springer, Dordrecht
Piletsky SA, Kurys YI, Rachkov AE et al (1994) Formation of matrix polymers sensitive to aniline and phenol. Russ J Electrochem 30:990–992
Vinokurov IA (1992) A new kind of redox sensor based on conducting polymer films. Sens Actuators B 10:31–35
Cabanilla S, Ebarvia BS, Sevilla F (2003) Piezoelectric biomimetic sensor for caffeine based on electrosynthesized polypyrrole. AsiaSENSE SENSOR 105–109
Jakoby B, Ismail GM, Byfield MP et al (1999) A novel molecularly imprinted thin film applied to a love wave gas sensor. Sens Actuators A 76:93–97
Knez M, Sumser M, Bittner AM et al (2004) Spatially selective nucleation of metal clusters on the tobacco mosaic virus. Adv Funct Mater 14:116–124
Lieberzeit PA, Glanznig G, Leidl A et al (2006) Ceramic materials for mass-sensitive sensors-detection of VOCs and monitoring oil degradation. Adv Sci Technol 45:1799–1802
Dickert FL, Greibl W, Rohrer A et al (2001) Sol–gel-coated quartz crystal microbalances for monitoring automotive oil degradation. Adv Mater 13:1327–1330
Dickert FL, Forth P, Lieberzeit PA et al (2000) Quality control of automotive engine oils with mass-sensitive chemical sensors-QCMs and molecularly imprinted polymers. Fresenius J Anal Chem 366:802–806
Aherne A, Alexander C, Payne MJ et al (1996) Bacteria-mediated lithography of polymer surfaces. J Am Chem Soc 118:8771–8772
Alexander C, Vulfson EN (1997) Imprinted polymers as protecting groups for regioselective modification of polyfunctional substrates. Adv Mater 9:751–755
Hayden O, Dickert FL (2001) Selective microorganism detection with cell surface imprinted polymers. Adv Mater 13:1480–1483
Iqbal N, Mustafa G, Rehman A et al (2010) QCM-arrays for sensing terpenes in fresh and dried herbs via bio-mimetic MIP layers. Sensors 10:6361–6376
Lieberzeit PA, Rehman A, Yaqub S et al (2008) Nanostructured particles and layers for sensing contaminants in air and water. Nano 3:205–208
Stetter JR, Jurs PC, Rose SL (1986) Detection of hazardous gases and vapors: pattern recognition analysis of data from an electrochemical sensor array. Anal Chem 58:860–866
Ji HS (1999) Selective piezoelectric odor sensing using molecularly imprinted polymers. Anal Chim Acta 390:93–100
Krupadam RJ (2011) An efficient fluorescent polymer sensing material for detection of traces of benzo[a]pyrene in environmental samples. Environ Chem Lett 9:389–395
Dickert FL, Forth P, Lieberzeit P et al (1998) Molecular imprinting in chemical sensing-detection of aromatic and halogenated hydrocarbons as well as polar solvent vapors. Fresenius J Anal Chem 360:759–762
Dickert FL, Thierer S (1996) Molecularly imprinted polymers for optochemical sensors. Adv Mater 8:987–990
Kröger S, Turner AP, Mosbach K et al (1999) Imprinted polymer based sensor system for herbicides using differential-pulse voltammetry on screen printed electrodes. Anal Chem 71:3698–3702
Xie C, Gao S, Zhou H et al (2011) Chemiluminescence sensor for sulfonylurea herbicide using molecular imprinted microspheres as recognition element. Luminescence 26:271–279
Schirhagl R, Latif U, Dickert FL (2011) Atrazine detection based on antibody replicas. J Mater Chem 21:14594–14598
Yaqub S, Latif U, Dickert FL (2011) Plastic antibodies as chemical sensor material for atrazine detection. Sens Actuators B 160:227–233
Iglesias RA, Tsow F, Wang R et al (2009) Hybrid separation and detection device for analysis of benzene, toluene, ethylbenzene, and xylenes in complex samples. Anal Chem 81:8930–8935
Percival CJ, Stanley S, Galle TM (2001) Crystal microbalances for the detection of terpenes. Anal Chem 73:4225–4228
González-RodrÃguez RM, Rial-Otero R, Cancho-Grande B et al (2008) Occurrence of fungicide and insecticide residues in trade samples of leafy vegetables. Food Chem 107:1342–1347
Sergeyeva TA, Piletsky SA, Brovko AA et al (1999) Selective recognition of atrazine by molecularly imprinted polymer membranes. Development of conductometric sensor for herbicides detection. Anal Chim Acta 392:105–111
Pardieu E, Cheap H, Vedrine C et al (2009) Molecularly imprinted conducting polymer based electrochemical sensor for detection of atrazine. Anal Chim Acta 649:236–245
Ye L, Haupt K (2004) Molecularly imprinted polymers as antibody and receptor mimics for assays, sensors and drug discovery. Anal Bioanal Chem 378:1887–1897
Ansell RJ (2004) Molecularly imprinted polymers in pseudoimmunoassay. J Chromatogr B 804:151–165
Chen L, Xu S, Li J (2011) Recent advances in molecular imprinting technology: current status, challenges and highlighted applications. Chem Soc Rev 40:2922–2942
Dickert FL, Hayden O (2002) Bioimprinting of polymers and sol–gel-phases. Selective detection of yeasts with imprinted polymers. Anal Chem 74:1302–1306
Seifner A, Lieberzeit P, Jungbauer C et al (2009) Synthetic receptors for selectively detecting erythrocyte ABO subgroups. Anal Chim Acta 651:215–219
Dickert FL, Hayden O, Bindeus R et al (2004) Bioimprinted QCM sensors for virus detection-screening of plant sap. Anal Bioanal Chem 378:1929–1934
Jenik M, Schirhagl R, Schirk C et al (2009) Sensing picornaviruses using molecular imprinting techniques on a quartz crystal microbalance. Anal Chem 81:6320–6326
Chow CF, Lam MHW, Leung MKP (2002) Fluorescent sensing of homocysteine by molecular imprinting. Anal Chim Acta 466:17–30
Nostrum CFV (2005) Molecular imprinting: a new tool for drug innovation. Drug Discov Today Technol 1:119–124
Moreno-Bondi MC, Navarro-Villoslada F, Benito-Pena E et al (2008) Molecularly imprinted polymers as selective recognition elements in optical sensing. Curr Anal Chem 4:316–340
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2012 Springer-Verlag Berlin Heidelberg
About this chapter
Cite this chapter
Mustafa, G., Lieberzeit, P.A. (2012). MIP Sensors on the Way to Real-World Applications. In: Piletsky, S., Whitcombe, M. (eds) Designing Receptors for the Next Generation of Biosensors. Springer Series on Chemical Sensors and Biosensors, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/5346_2012_21
Download citation
DOI: https://doi.org/10.1007/5346_2012_21
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-32328-7
Online ISBN: 978-3-642-32329-4
eBook Packages: Chemistry and Materials ScienceChemistry and Material Science (R0)