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Molecular Biology of Metal Homeostasis and Detoxification pp 37–58Cite as

Zinc in yeast: mechanisms involved in homeostasis

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Part of the book series: Topics in Current Genetics ((TCG,volume 14))

Abstract

The first eukaryotic zinc uptake transporter was discovered in the yeast, Saccharomyces cerevisiae. Since then, this organism has been an invaluable tool for the discovery of genes involved in zinc homeostasis. Genomic and proteomic studies have revealed an abundance of Zn2+-regulated genes and Zn2+-binding proteins. The large number of essential functions of Zn2+ necessitates a complex homeostatic mechanism involving the transport and storage of Zn2+ as well as its allocation to essential sites. Studies in yeast have elucidated the opposing roles of the ZIP and CDF Zn2+ transporter families and uncovered additional transport systems. The transcription factor, Zap1p, functions as the central Zn2+ sensor by regulating genes involved in Zn2+ uptake and adaptation to Zn2+-deficiency. The investigation of the role of Zn2+ in the regulation of signaling pathways is becoming a primary research direction, and yeast will undoubtedly play a major role in any discoveries in this field as well.

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  1. Department of Chemistry, University of Florida, P.O. Box 117200, Gainesville, FL, 32611, USA

    Lisa M. Regalla & Thomas J. Lyons

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  1. Lisa M. Regalla
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  2. Thomas J. Lyons
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Markus J. Tamas Enrico Martinoia

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Regalla, L.M., Lyons, T.J. (2005). Zinc in yeast: mechanisms involved in homeostasis. In: Tamas, M.J., Martinoia, E. (eds) Molecular Biology of Metal Homeostasis and Detoxification. Topics in Current Genetics, vol 14. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4735_98

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