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The role of metabolomics in systems biology

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Metabolomics

Part of the book series: Topics in Current Genetics ((TCG,volume 18))

Abstract

The metabolome comprises the complete set of metabolites, the non-genetically encoded substrates,intermediates, and products of metabolic pathways, associated to a cell. By representing integrativeinformation across multiple functional levels and by linking DNA encoded processes with the environment,the metabolome offers a window to map core attributes responsible for different phenotypes. Givenincreasing demand to quantitatively identify the metabolome and understand how trafficking of metabolitesthrough the metabolic network impact cellular behavior, metabolomics has emerged as an important complementarytechnology to the cell-wide measurements of mRNA, proteins, fluxes, and interactions (e.g. protein-DNA).Metabolomics is already a powerful tool in drug discovery and development and in metabolic engineering.While maintaining these strengths, the field promises to play a heightened role in systems biologyresearch, which is transforming the practice of medicine and our ability to engineer living organisms.

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Authors and Affiliations

  1. Center for Microbial Biotechnology, BioCentrum-DTU, Technical University of Denmark, Søltofts Plads, DK-2800, Kgs. Lyngby, Denmark

    Jens Nielsen & Michael C. Jewett

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  1. Jens Nielsen
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  2. Michael C. Jewett
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Correspondence to Jens Nielsen .

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Jens Nielsen Michael C. Jewett

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© 2007 Springer-Verlag Berlin Heidelberg

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Nielsen, J., Jewett, M.C. (2007). The role of metabolomics in systems biology. In: Nielsen, J., Jewett, M.C. (eds) Metabolomics. Topics in Current Genetics, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4735_2007_0228

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