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Near-Infrared Luminescent Labels and Probes Based on Lanthanide Ions and Their Potential for Applications in Bioanalytical Detection and Imaging

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Lanthanide Luminescence

Part of the book series: Springer Series on Fluorescence ((SS FLUOR,volume 7))

Abstract

The use of near-infrared (NIR) light in bioanalytical detection and biological imaging presents certain advantages over UV–visible light in terms of penetration depth, reduction of background signals and decreased phototoxicity. Under suitable conditions, complexes of ytterbium(III)-, neodymium(III)- and erbium (III)-containing organic chromophores may display relatively bright NIR luminescence upon excitation with visible light. This contrasts with the more commonly studied visibly luminescent europium(III) and terbium(III) complexes, which generally need UV or blue light for excitation. We discuss the current knowledge on NIR luminescence of lanthanide complexes (including holmium(III), praseodymium(III) and thulium(III)) in solution. It is suggested that among the NIR luminescent lanthanide complexes, ytterbium(III) complexes are likely to be the most promising candidates for biophotonic applications. The study of NIR luminescence and its application in bioanalytical detection are enabled by progress in detector and light source technology, which are also addressed. Recent developments in lanthanide-based NIR luminescent materials, including complexes and doped nanoparticles, are discussed in the light of their potential for bioanalytical application.

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Abbreviations

CCD:

Charge-coupled device

DNA:

Deoxyribonucleic acid

DTPA:

Diethylenetriamine pentaacetic acid (or any of its conjugate acetate ions)

ECL:

Electrochemiluminescence

EDTA:

Ethylenediamine tetraacetic acid (or any of its conjugate acetate ions)

FRET:

Förster resonance energy transfer, a form of excitation energy transfer (sometimes referred to with the incorrect term “fluorescence resonance energy transfer”)

NIR:

Near-infrared

OD:

Optical density

PMT:

Photomultiplier tube

UV:

Ultraviolet

Tris:

Tris(hydroxymethyl)aminomethane

ε :

Molar absorption coefficient

ε Ln :

Molar absorption coefficient of the lanthanide ion

ε sens :

Molar absorption coefficient of the sensitiser

εΦ :

Photoluminescence brightness (product of molar absorption coefficient and photoluminescence quantum yield)

η sens :

Excitation energy transfer efficiency from the sensitiser to the lanthanide ion in a luminescent lanthanide complex

τ obs :

Observed photoluminescence decay time

τ rad :

Radiative (or “natural”) lifetime of the luminescent transition

Φ tot :

Overall photoluminescence quantum yield of a sensitiser-modified luminescent lanthanide complex (excitation via the sensitiser)

Φ Ln :

Intrinsic photoluminescence quantum yield of the lanthanide ion in a luminescent lanthanide complex

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Authors and Affiliations

  1. Centre National de la Recherche Scientifique, Ecole Normale Supérieure de Cachan/Bretagne, SATIE (CNRS UMR8029), Campus de Ker Lann, 35170, Bruz, France

    Martinus H. V. Werts

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  1. Martinus H. V. Werts
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Correspondence to Martinus H. V. Werts .

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  1. , Department of Cell Biology and Anatomy, University of Turki, Tykistökatu 6A, Turku, 20520, Finland

    Pekka Hänninen

  2. , Department of Cell Biology and Anatomy, University of Turku, Tykistökatu 6A, Turku, 20520, Finland

    Harri Härmä

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Werts, M.H.V. (2010). Near-Infrared Luminescent Labels and Probes Based on Lanthanide Ions and Their Potential for Applications in Bioanalytical Detection and Imaging. In: Hänninen, P., Härmä, H. (eds) Lanthanide Luminescence. Springer Series on Fluorescence, vol 7. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4243_2010_9

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