Abstract
This chapter will give a short introduction into current technology related and biology related problems in the microarray technology, approaches undertaken to overcome such problems, and, finally, it will present some key features of most commercial platforms which have emerged over the past few years and may help to solve some technical problems at least related to the instrumentation side. Standard operating protocols, guidelines, as well as careful and routine checking of the instrumentation, such as spotting or hybridization devices as well as microarray reader (laser/charge-coupled device (CCD) camera), are necessary for running a microarray platform successfully. Furthermore, standardized reference material, databases, and analysis software will be necessary for generating confidential data across all platforms and laboratories and will additionally support the full power of DNA microarray technology as a research and diagnostic tool.
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Nietfeld, W. (2008). Comparability of Microarray Experiments from the Instrument and the Sample Site and Approaches Towards Standardization . In: Resch-Genger, U. (eds) Standardization and Quality Assurance in Fluorescence Measurements II. Springer Series on Fluorescence, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/4243_2008_033
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DOI: https://doi.org/10.1007/4243_2008_033
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