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Orphan G Protein-Coupled Receptors and Novel Neuropeptides pp 181–199Cite as

Biological Function of Prokineticins

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 46))

Abstract

Secreted peptides have been implicated in diverse physiological functions. Prokineticins are a pair of regulatory peptides that signal through two highly homologous G protein-coupled receptors. Prokineticins possess a unique structural motif of five disulfide bonds and conserved N-terminal stretches. Diverse biological functions, ranging from development to adult physiology, have been attributed to prokineticins. Herein we provide an overview of current knowledge of this interesting pair of regulatory peptides.

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Authors and Affiliations

  1. Department of Pharmacology, University of California, 92697, Irvine, CA, USA

    Q.-Y. Zhou

  2. Department of Animal Sciences, The Hebrew University of Jerusalem, Rehovot, Israel

    R. Meidan

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Olivier Civelli Qun-Yong Zhou

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Zhou, QY., Meidan, R. (2008). Biological Function of Prokineticins. In: Civelli, O., Zhou, QY. (eds) Orphan G Protein-Coupled Receptors and Novel Neuropeptides. Results and Problems in Cell Differentiation, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_2007_053

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