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Inhibitory Regulation of Excitatory Neurotransmission pp 123–143Cite as

Regulation of Excitation by Glycine Receptors

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Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 44))

Abstract

Our knowledge of glycine receptor (GlyR) regulation of excitation has advanced significantly in recent years. GlyRs are widespread in the CNS, are heterogeneous, and undergo developmental changes. Activation of GlyRs of immature neurons induces outflow of Cl–, membrane depolarization, neuronal excitation, calcium influx, and transmitter release, in contrast to the inhibitory effects these receptors have in mature neurons. Thus, GlyRs are important for neuronal excitability in both the developing and the mature CNS. This chapter is an overview of selective studies on the newly discovered roles of GlyRs in regulating neuronal excitation, and inhibition, particularly in the upper brain areas.

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  1. Department of Anesthesiology, UMDNJ, New Jersey Medical School, 185 South Orange Avenue, 07103, Newark, NJ, USA

    Jiang-Hong Ye

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Mark G. Darlison

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Ye, JH. (2007). Regulation of Excitation by Glycine Receptors. In: Darlison, M.G. (eds) Inhibitory Regulation of Excitatory Neurotransmission. Results and Problems in Cell Differentiation, vol 44. Springer, Berlin, Heidelberg. https://doi.org/10.1007/400_2007_029

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