Extracellular Matrix and Synaptic Functions

  • Alexander DityatevEmail author
  • Renato Frischknecht
  • Constanze I. Seidenbecher
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 43)


Comprehensive analysis of neuromuscular junction formation and recent data on synaptogenesis and long-term potentiation in the central nervous system revealed a number of extracellular matrix (ECM) molecules regulating different aspects of synaptic differentiation and function. The emerging mechanisms comprise interactions of ECM components with their cell surface receptors coupled to tyrosine kinase activities (agrin, integrin ligands, and reelin) and interactions with ion channels and transmitter receptors (Narp, tenascin-R and tenascin-C). These interactions may shape synaptic transmission and plasticity of excitatory synapses either via regulation of Ca 2+ entry and postsynaptic expression of transmitter receptors or via control of GABAergic inhibition. The ECM molecules, derived from both neurons and glial cells and secreted into the extracellular space in an activity-dependent manner, may also shape synaptic plasticity through setting diffusion constraints for neurotransmitters, trophic factors and ions.


Synaptic Plasticity AMPA Receptor Neural Cell Adhesion Molecule Synaptic Function Chondroitin Sulfate Proteoglycan 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



acetylcholine receptor


alpha-amino-3-hydroxy-5-methyl-4 isoxazolepropionic acid


apolipoprotein E receptor 2


hippocampal cornu ammonis regions 1,3


Ca2+/calmodulin-dependent protein kinase II


central nervous system


cAMP-responsive element-binding protein


chondroitin sulfate


chondroitin sulfate proteoglycan


extracellular matrix


excitatory postsynaptic current




gamma-aminobutyric acid


G-protein-coupled inwardly rectifying K+ channel


glutamate receptor subunit 1


hyaluronic acid


heparin-binding growth-associated molecule


human natural killer cell antigen 1


heparan sulfate proteoglycan


integrin-associated protein


knock out


long-term potentiation


mitogen-activated protein kinase


matrix metalloprotease


muscle-specific receptor tyrosine kinase


neuronal activity-regulated pentraxin




neuromuscular junction


neuronal pentraxin 1


NMDA receptor 2B


oligodendrocyte progenitor cells


protein kinase C


polysialylated neural cell adhesion molecule


phosphacan short isoform


receptor-associated protein


receptor protein tyrosine phosphatase


synapse-associated protein 90 kDa/post-synaptic density protein of 95 kD


synaptic vesicle protein 2








voltage-dependent calcium channel


very low density lipoprotein


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Work in our laboratories is supported by the Deutsche Forschungsgemeinschaft grants Di 702/4-1 and -2, and Gu 230/5-1 and by the Swiss National Fonds.


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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Alexander Dityatev
    • 1
    Email author
  • Renato Frischknecht
    • 2
  • Constanze I. Seidenbecher
    • 2
  1. 1.Institut für Neurophysiologie und PathophysiologieUniversitätsklinikum Hamburg-EppendorfHamburgGermany
  2. 2.Leibniz-Institut für NeurobiologieMagdeburgGermany

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