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Molecular Regulation of Cytoskeletal Rearrangements During T Cell Signalling

  • Theresia E. B. Stradal
  • Rico Pusch
  • Stefanie KlicheEmail author
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 43)

Abstract

Regulation of the cytoskeleton in cells of the haematopoietic system is essential for fulfilling diverse tasks such as migration towards a chemoattractant, phagocytosis or cell–cell communication. This is particularly true for the many types of T cells, which are at the foundation of the adaptive immune system in vertebrates. Deregulation of actin filament turnover is known to be involved in the development of severe immunodeficiencies or immunoproliferative diseases. Therefore, molecular dissection of signalling complexes and effector molecules, which leads to controlled cytoskeletal assembly, has been the focus of immunological research in the last decade.

In the past, cytoskeletal remodelling was frequently understood as the finish line of signalling, while today it becomes increasingly evident that actin and microtubule dynamics are required for proper signal transmission in many processes such as T cell activation. Significant effort is made in many laboratories to further elucidate the contribution of cytoskeletal remodelling to immune function.

The objective of this article is to summarise the current knowledge on how actin and microtubules are reorganised to support the formation of structures as diverse as the immunological synapse and peripheral protrusions during cell migration.

TCR CD28 Actin Tubulin Cytoskeleton Immunological synapse 

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Notes

Acknowledgments

The work was funded in part by the DFG (KL1292/5-1 to SK and For471 to TEBS). We thank Dr. Martin Kliche for preparation of the schematic figures and Dr. Klemens Rottner for helpful discussions and critically reading the manuscript.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • Theresia E. B. Stradal
    • 1
  • Rico Pusch
    • 2
  • Stefanie Kliche
    • 2
    Email author
  1. 1.Signalling and Motility GroupGerman Research Centre for Biotechnology (GBF)BraunschweigGermany
  2. 2.Institute of ImmunologyOtto von Guericke UniversityMagdeburgGermany

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