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Molecular Organization and Assembly of the Central Inhibitory Postsynapse

  • I. Lorena Arancibia-Carcamo
  • Stephen J. MossEmail author
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 43)

Abstract

γ-Amino butyric acid type A (GABAA) receptors are the major sites of fast synaptic inhibition in the brain. GABAA receptors play an important role in regulating neuronal excitability and in addition have been implicated in numerous neurological disorders. In order to understand synaptic inhibition it is important to comprehend the cellular mechanisms, that neurons utilize to regulate the accumulation and regulation of GABAA receptors at postsynaptic inhibitory specializations. Over the past decade a number of GABAA receptor interacting proteins have been identified allowing us to further understand the trafficking, targeting and clustering of these receptors as well as the regulation of receptor stability. In the following review we examine the proteins identified as GABAA receptor binding partners and other components of the inhibitory postsynaptic scaffold, and how they contribute to the construction of inhibitory synapses and the dynamic modulation of synaptic inhibition.

Keywords

GABAA Receptor Glycine Receptor Inhibitory Synapse Synaptic Inhibition GABAA Receptor Subtype 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Notes

Acknowledgments

The authors would like to thank Dr. J.T. Kittler for critical reading of this manuscript. ILAC is the recipient of a Wellcome trust prize Studentship and SJM is supported by Grants from the MRC (UK), the Wellcome trust and NIH NINDS grants NS047478, NS048045 & NS051195.

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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  • I. Lorena Arancibia-Carcamo
    • 1
  • Stephen J. Moss
    • 2
    Email author
  1. 1.Department of PharmacologyUniversity College LondonLondonUK
  2. 2.Department of Neuroscience, School of MedicineUniversity of PennsylvaniaPhiladelphiaUSA

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