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Neuron-Glia Interactions at the Node of Ranvier

  • Matthew N. RasbandEmail author
Chapter
Part of the Results and Problems in Cell Differentiation book series (RESULTS, volume 43)

Abstract

Rapid, faithful, and efficient action potential propagation in mammalian axons is a consequence of myelin and clustered Na + channels. Both myelination and node of Ranvier formation require complex intercellular interactions between neurons and glia that result in profound molecular, morphological, and functional changes in each cell type. This review will focus on the molecular and cellular mechanisms that underlie neuron-glia interactions at the node of Ranvier. In particular, the proteins and protein complexes, and how they participate in node of Ranvier formation and maintenance, will be discussed. Traditionally, myelinating glia have been viewed as merely passive players in neuronal function, conferring on the axons they ensheath various electrical properties that facilitate action potential conduction. However, it is now recognized that this view is incomplete. This review will discuss several examples illustrating how myelinating glia actively regulate the excitable properties of axons including the kinds of channels expressed and their subcellular localization.

Keywords

Schwann Cell Myelinated Axon Axon Initial Segment Septate Junction Action Potential Conduction 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Notes

Acknowledgments

Supported by NIH NS044916.

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© Springer-Verlag Berlin Heidelberg 2006

Authors and Affiliations

  1. 1.Department of NeuroscienceUniversity of Connecticut Health CenterFarmingtonUSA

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