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Sphingosine 1-Phosphate-Related Metabolism in the Blood Vessel

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Sphingolipid Biology

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Summary

Sphingosine 1-phosphate (S1P) is an important intercellular lipid mediator, especially in vascular biology. Blood platelets store S1P abundantly and release this bioactive lysophospholipid extracellularly upon stimulation. Vascular endothelial and smooth muscle cells respond dramatically to this platelet-derived lipid. Regulating S1P biological activities may be valuable to treat vascular disorders, and, as such, requires a better understanding of those mechanisms that mediated vascular S1P. Various factors may mediate the level and function of plasma S1P in vivo, these include S1P release from platelets and S1P distribution between albumin and lipoproteins as well as S1P receptor (S1P) expression and lipid phosphate phosphatase activity on vascular cells. In atherosclerotic diseases, where the plasma levels of lipids and lipoproteins or endothelial cell functions are altered, modulating effects of S1P may be of pathophysiological importance.

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Authors and Affiliations

  1. Department of Laboratory Medicine, Graduate School of Medicine, The University of Tokyo, Tokyo, 113-8655, Japan

    Yutaka Yatomi & Shinya Aoki

  2. Department of Biomembrane and Biofunctional Chemistry, Graduate School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan

    Yasuyuki Igarashi

Authors
  1. Yutaka Yatomi
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  2. Shinya Aoki
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  3. Yasuyuki Igarashi
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Editors and Affiliations

  1. Brain Science Institute, The Institute of Physical and Chemical Research (Riken), 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Yoshio Hirabayashi

  2. Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science and Graduate School of Life Science, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan

    Yasuyuki Igarashi

  3. School of Biology and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA

    Alfred H. Merrill Jr.

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© 2006 Springer-Verlag Tokyo

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Yatomi, Y., Aoki, S., Igarashi, Y. (2006). Sphingosine 1-Phosphate-Related Metabolism in the Blood Vessel. In: Hirabayashi, Y., Igarashi, Y., Merrill, A.H. (eds) Sphingolipid Biology. Springer, Tokyo. https://doi.org/10.1007/4-431-34200-1_33

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