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Sphingosine-1-Phosphate and the Regulation of Immune Cell Trafficking

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Sphingolipid Biology

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Summary

Sphingosine-1-phosphate (S1P) is an extracellular sphingolipid signaling molecule that acts through a family of G-protein coupled receptors. The signaling pathways stimulated by S1P receptors profoundly affect the activities of lymphocytes and endothelial cells. Pharmacological and genetic experiments have clearly established the SIP-SIP receptor system as a dominant regulatory axis for the trafficking of lymphocytes. Manipulating this regulatory axis might lead to the development of therapies that target immune system dysfunctions.

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Authors and Affiliations

  1. Genetics of Development and Disease Branch, National Institutes of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, 20892, USA

    Maria Laura Allende & Richard L. Proia

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  1. Maria Laura Allende
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Editors and Affiliations

  1. Brain Science Institute, The Institute of Physical and Chemical Research (Riken), 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Yoshio Hirabayashi

  2. Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science and Graduate School of Life Science, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan

    Yasuyuki Igarashi

  3. School of Biology and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA

    Alfred H. Merrill Jr.

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© 2006 Springer-Verlag Tokyo

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Allende, M.L., Proia, R.L. (2006). Sphingosine-1-Phosphate and the Regulation of Immune Cell Trafficking. In: Hirabayashi, Y., Igarashi, Y., Merrill, A.H. (eds) Sphingolipid Biology. Springer, Tokyo. https://doi.org/10.1007/4-431-34200-1_30

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