Summary
Nervous system functions depend on the neuronal networks formed in part by axons. During development, axons migrate long distances to reach particular targets. A variety of environmental cues regulate and guide axon elongation by binding to relevant receptors expressed on the axonal growth cone at its tip. Activated receptors generate specific intracellular signals in a subcellular area of the growth cone, thereby controlling its directional motility. Recent work identified lipid rafts, or cholesterol- and glycosphingolipid- enriched microdomains, in the cell membrane a possible sited for the organization of spatially defined signals. For example, to stimulate axon elongation, cell adhesion molecules require functional rafts in the growth cone periphery. An extracellular gradient of axon guidance cues can induce growth cone turning by recruiting specific receptors to rafts and activating their downstream signals in a polarized manner. This chapter will examine the role of lipid rafts in mediating the directional motility of growth cones.
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Kamiguchi, H. (2006). The Role of Lipid Rafts in Axon Growth and Guidance. In: Hirabayashi, Y., Igarashi, Y., Merrill, A.H. (eds) Sphingolipid Biology. Springer, Tokyo. https://doi.org/10.1007/4-431-34200-1_19
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DOI: https://doi.org/10.1007/4-431-34200-1_19
Publisher Name: Springer, Tokyo
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