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Overview of Acid and Neutral Sphingomyelinases in Cell Signaling

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Book cover Sphingolipid Biology

Summary

Ceramide, which forms through the activation of sphingomyelinases (SMases), is as a bioactive lipid that mediates cell growth, differentiation, stress responses, and programmed cell death (apoptosis). Molecular and biochemical examinations to determine the role of these enzymes in ceramide-mediated cell signaling is possible with the recent availability of the cloned acid SMase (A-SMase) and neutral SMase (N-SMase). Here we review the recent experimental data and discuss its relevance for understanding the biochemical and molecular properties, regulation, mechanisms and roles of A-SMase and N-SMase.

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology, Medical University of South Carolina, Charleston, SC, 29425, USA

    Youssef Zeidan, Norma Marchesini & Yusuf A. Hannun

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  1. Youssef Zeidan
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  2. Norma Marchesini
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  3. Yusuf A. Hannun
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Editors and Affiliations

  1. Brain Science Institute, The Institute of Physical and Chemical Research (Riken), 2-1 Hirosawa, Wako, Saitama, 351-0198, Japan

    Yoshio Hirabayashi

  2. Department of Biomembrane and Biofunctional Chemistry, Faculty of Advanced Life Science and Graduate School of Life Science, Hokkaido University, Kita 12, Nishi 6, Kita-ku, Sapporo, 060-0812, Japan

    Yasuyuki Igarashi

  3. School of Biology and the Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, 30332, USA

    Alfred H. Merrill Jr.

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Zeidan, Y., Marchesini, N., Hannun, Y.A. (2006). Overview of Acid and Neutral Sphingomyelinases in Cell Signaling. In: Hirabayashi, Y., Igarashi, Y., Merrill, A.H. (eds) Sphingolipid Biology. Springer, Tokyo. https://doi.org/10.1007/4-431-34200-1_12

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