Abstract
In the recent years, the prognosis of brain tumor patients has dramatically improved due to recent advances in neurosurgical operative procedures, which are included microneurosurgical techniques, development of intraoperative computer-assisted neuronavigation system (like as Neuronavigator), functional mapping, and neuro monitoring system during operative procedure. Furthermore, development of neuroendoscopic surgery, intravascular surgery and radiosurgery are also assisted the improvement of survival and/or functional prognostic rate of brain tumor patients. According to a report by the Committee of Brain Tumor Registry of Japan, the ten year survival rate of patients with benign brain tumors (meningioma, neurinoma and pituitary adenoma) is more than 95%. In contrast, patients with glioma (which constitute 33% of primary brain tumor cases) still have a poor prognosis, especially in the case of malignant, which is included anaplastic astrocytoma and glioblastoma. This poor prognosis is related to the fact that malignant glioma cells aggressively infiltrate into normal brain tissues, making total removal of the tumor impossible. The median survival time of glioblastoma patients is less than two years, despite multimodality treatment with extensive surgical resection and adjuvant therapies using radiotherapy, chemotherapy, immunotherapy, hyperthermia and so on. In order to overcome this formidable neoplasm, the effectiveness of molecular biology using gene therapy has been investigated since 1992 in U.S.A. and 2000 in Japan. In this paper, molecular genetic studies and current state of gene therapy for brain tumors is described.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Yoshida J, Mizuno M, Fujii M, et al (2004) Humna gene therapy for malignant gliomas (glioblastoma multiforme and anaplastic astrocytoma) by in vivo transduction with human interferon beta gene using cationic liposome. Hum Gene Ther 15:77–86
Yoshida J, Mizuno M, Wakabayashi T (2004) Interferon-beta gene therapy for cancer: Basic research to clinical application. Cancer Sci 95:858–865
Mizuno M, Yoshida J, Sugita K, et al (1990) Growth inhibition of glioma cells transfected with the human β-interferon gene by liposomes coupled with a monoclonal antibody. Cancer Res 50:7826–7829
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Springer-Verlag Tokyo
About this paper
Cite this paper
Wakabayashi, T. et al. (2006). Human Gene Therapy for Malignant Gliomas. In: Kanno, T., Kato, Y. (eds) Minimally Invasive Neurosurgery and Multidisciplinary Neurotraumatology. Springer, Tokyo. https://doi.org/10.1007/4-431-28576-8_19
Download citation
DOI: https://doi.org/10.1007/4-431-28576-8_19
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-28551-9
Online ISBN: 978-4-431-28576-2
eBook Packages: MedicineMedicine (R0)