Abstract
Cell therapy with polymer capsules has been developed for central nervous system diseases [1], such as Parkinson’s disease [2], amyotrophic lateral sclerosis [3] and cancer pain [4,5]. The use of encapsulated cells has great potential advantages, including constant delivery of the products and avoidance of rejection by the host immune system. An ability to control the expression levels of products in cell transplantation therapy would provide further significant advantages. Ideally, transfected genes in the implanted grafts should be regulated intrinsically, leading to delivery of neuropeptides or transmitters on demand. A practical alternative might be to control gene expression of transfected cells exogenously. Several attempts to control gene expression in such cells have been reported, i.e., regulation by steroid hormones [6], isopropyl [3-D-thiogalactoside [7], and heavy metals [8], but most of these substances may induce serious side effects in vivo.
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References
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© 2006 Springer-Verlag Tokyo
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Saitoh, Y., Eguchi, Y., Yoshimine, T., Boileau, G. (2006). Controlled Secretion of β-endorphin from Human Embryonic Kidney Cells Carrying a Tet-on-NL1-β-endorphin Fusion Gene: Gene Therapy of Pain. In: Kanno, T., Kato, Y. (eds) Minimally Invasive Neurosurgery and Multidisciplinary Neurotraumatology. Springer, Tokyo. https://doi.org/10.1007/4-431-28576-8_18
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DOI: https://doi.org/10.1007/4-431-28576-8_18
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-28551-9
Online ISBN: 978-4-431-28576-2
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