Skip to main content
SpringerLink
Log in
Book cover

The Diversity of Gastric Carcinoma pp 139–149Cite as

Hepatoid Adenocarcinoma of the Stomach: Biological Significance of Hepatic Transdifferentiation in Adenocarcinoma Cells

  • Chapter

  • 578 Accesses

Conclusions

Hepatoid adenocarcinoma is an extrahepatic carcinoma with functionally and structurally distinctive foci of hepatocellular differentiation. The usual presence of adenocarcinoma indicates the emergence of hepatocellular transdifferentiation from adenocarcinoma cells. Hepatoid adenocarcinoma most commonly occurs in the stomach, but other gastrointestinal and genitourinary organs are also common sites of origin. Master transcriptional regulators, particularly liver-enriched nuclear factors, might be involved in the transdifferentiation process, as well as in the biology of hepatoid adenocarcinoma tissues.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Ishikura H, Fukasawa Y, Ogasawara K, et al (1985) An AFP-producing gastric carcinoma with features of hepatic differentiation. A case report. Cancer (Phila) 56:840–848

    CAS  PubMed  Google Scholar 

  2. Ishikura H, Kirimoto K, Shamoto M, et al (1986) Hepatoid adenocarcinoma of the stomach: an analysis of seven cases. Cancer (Phila) 58:119–126

    CAS  PubMed  Google Scholar 

  3. Yano T, Kishimoto T, Tomaru U, et al (2003) Further evidence of hepatic transdifferentiation in hepatoid adenocarcinomas of the stomach: quantitative analysis of mRNA for albumin and hepatocyte nuclear factor-4α. Pathology 35:75–78

    Article  CAS  PubMed  Google Scholar 

  4. Nagai E, Ueyama T, Yao T, et al (1993) Hepatoid adenocarcinoma of the stomach. A clinicopathologic and immunohistochemical analysis. Cancer (Phila) 72:1827–1835

    CAS  PubMed  Google Scholar 

  5. Foschini MP, Baccarini P, Dal Monte PR, et al (1998) Albumin gene expression in adenocarcinomas with hepatoid differentiation. Virchows Arch 433:537–541

    CAS  PubMed  Google Scholar 

  6. Kudo M, Takamine Y, Nakamura K, et al (1992) Des-γ-carboxy prothrombin (PIVKA-II) and α-fetoprotein-producing IIc-type early gastric cancer. Am J Gastroenterol 87:1859–1862

    CAS  PubMed  Google Scholar 

  7. Maitra A, Murakata LA, Albores-Saavedra J (2001) Immunoreactivity for hepatocyte paraffin 1 antibody in hepatoid adenocarcinoma of the gastrointestinal tract. Am J Clin Pathol 115:689–694

    CAS  PubMed  Google Scholar 

  8. Villari D, Caruso R, Grosso M, et al (2002) Hep Par 1 in gastric and bowel carcinomas: an immunohistochemical study. Pathology 34:423–426

    Article  CAS  PubMed  Google Scholar 

  9. Matsunou H, Konishi F, Jalal REA, et al (1994) Alpha-fetoprotein-producing gastric carcinoma with enteroblastic differentiation. Cancer (Phila) 73:534–540

    CAS  PubMed  Google Scholar 

  10. Ooi A, Nakanishi I, Sakamoto N, et al (1990) Alpha-fetoprotein (AFP)-producing gastric carcinoma: is it hepatoid differentiation? Cancer (Phila) 65:1741–1747

    CAS  PubMed  Google Scholar 

  11. Motoyama T, Aizawa K, Watanabe H, et al (1993) α-Fetoprotein producing gastric carcinomas: a comparative study of three different subtypes. Acta Pathol Jpn 43:654–661

    CAS  PubMed  Google Scholar 

  12. Aizawa K, Motoyama T, Suzuki T, et al (1994) Different characteristics of hepatoid and non-hepatoid α-fetoprotein-producing gastric carcinomas: an experimental study using xenografted tumors. Int J Cancer 58:430–435

    CAS  PubMed  Google Scholar 

  13. Aoyagi K, Koufuji K, Yano S, et al (2003) Alpha-fetoprotein-producing early gastric cancer: report of two cases. Kurume Med J 50:63–66

    PubMed  Google Scholar 

  14. Tsurumachi T, Yamamoto H, Watanabe K, et al (1997) Resection of liver metastasis from alpha-fetoprotein-producing early gastric cancer: report of a case. Surg Today 27:563–566

    CAS  PubMed  Google Scholar 

  15. Ishikura H, Kishimoto T, Andachi H, et al (1997) Gastrointestinal hepatoid adenocarcinoma: venous permeation and mimicry of hepatocellular carcinoma: a report of four cases. Histopathology (Oxf) 31:47–54

    Article  CAS  PubMed  Google Scholar 

  16. Kang GH, Kim YI (1998) α-Fetoprotein-producing gastric carcinoma presenting focal hepatoid differentiation in metastatic lymph nodes. Virchows Arch 432:85–87

    CAS  PubMed  Google Scholar 

  17. Ihling C, Shaefer HE, Baumgartner U, et al (1995) Hepatoid adenocarcinoma of the stomach: a case report. Gen Diagn Pathol 141:61–65

    CAS  PubMed  Google Scholar 

  18. Roberts CC, Colby TV, Batts KP (1997) Carcinoma of the stomach with hepatocyte differentiation (hepatoid adenocarcinoma). Mayo Clin Proc 72:1154–1160

    CAS  PubMed  Google Scholar 

  19. Morinaga S, Takahashi Y (1996) Primary hepatocellular carcinoma and hepatoid adenocarcinoma of the stomach with liver metastasis: an unusual association. Jpn J Clin Oncol 26:258–263

    CAS  PubMed  Google Scholar 

  20. Motoyama T, Higuchi M, Taguchi J (1995) Combined choriocarcinoma, hepatoid adenocarcinoma, small cell carcinoma and tubular adenocarcinoma in the oesophagus. Virchows Arch 427:451–454

    Article  CAS  PubMed  Google Scholar 

  21. Tanigawa H, Kida Y, Kuwao S, et al (2002) Hepatoid adenocarcinoma in Barrett’s esophagus associated with achalasia: first case report. Pathol Int 52:141–146

    Article  PubMed  Google Scholar 

  22. Gardiner GW, Lajoie G, Keith R (1992) Hepatoid adenocarcinoma of the papilla of Vater. Histopathology (Oxf) 20:541–544

    CAS  PubMed  Google Scholar 

  23. Hocking GR, Shembrey M, Hay D, et al (1995) Alpha-fetoprotein-producing adenocarcinoma of the sigmoid colon with possible hepatoid differentiation. Pathology 27:277–279

    Article  CAS  PubMed  Google Scholar 

  24. Nakashima H, Nagafuchi K, Satoh H, et al (2000) Hepatoid adenocarcinoma of the gallbladder. J Hepatobiliary Pancreat Surg 7:226–230

    Article  CAS  PubMed  Google Scholar 

  25. Yano T, Ishikura H, Wada T, et al (1999) Hepatoid adenocarcinoma of the pancreas. Histopathology (Oxf) 35:90–92

    Article  CAS  PubMed  Google Scholar 

  26. Ishikura H, Kanda M, Ito M, et al (1990) Hepatoid adenocarcinoma: a distinctive histological subtype of alpha-fetoprotein-producing lung carcinoma. Virchows Arch A Pathol Anat Histopathol 417:73–80

    Article  CAS  PubMed  Google Scholar 

  27. Arnould L, Drouot F, Fargeot P, et al (1997) Hepatoid adenocarcinoma of the lung: report of a case of an unusual α-fetoprotein-producing lung tumor. Am J Surg Pathol 21:1113–1118

    Article  CAS  PubMed  Google Scholar 

  28. Ishikura H, Ishiguro T, Enatsu C, et al (1991) Hepatoid adenocarcinoma of the renal pelvis producing alpha-fetoprotein of hepatic type and bile pigment. Cancer (Phila) 67:3051–3056

    CAS  PubMed  Google Scholar 

  29. Sinard J, Macleay L Jr, Melamed J (1994) Hepatoid adenocarcinoma in the urinary bladder. Unusual localization of a newly recognized tumor type. Cancer (Phila) 73:1919–1925

    CAS  PubMed  Google Scholar 

  30. Hoshida Y, Nagakawa T, Mano S, et al (1996) Hepatoid adenocarcinoma of the endometrium associated with alpha-fetoprotein production. Int J Gynecol Pathol 15:266–269

    CAS  PubMed  Google Scholar 

  31. Takahashi Y, Inoue T (2003) Hepatoid carcinoma of the uterus that collided with carcinosarcoma. Pathol Int 53:323–326

    PubMed  Google Scholar 

  32. Yoyoda H, Hirai T, Ishii E (2000) Alpha-fetoprotein producing uterine corpus carcinoma: a hepatoid adenocarcinoma of the endometrium. Pathol Int 50:847–852

    Google Scholar 

  33. Aoyama T, Mizuno T, Andoh K, et al (1996) α-Fetoprotein-producing (hepatoid) carcinoma of the fallopian tube. Gynecol Oncol 63:261–266

    Article  CAS  PubMed  Google Scholar 

  34. Ishikura H, Scully RE (1987) Hepatoid carcinoma of the ovary. A newly described tumor. Cancer (Phila) 60:2775–2784

    CAS  PubMed  Google Scholar 

  35. Senzaki H, Kiyozuka Y, Mizuoka H, et al (1999) An autopsy case of hepatoid carcinoma of the ovary with PIVKA-II production: immunohistochemical study and literature review. Pathol Int 49:164–169

    CAS  PubMed  Google Scholar 

  36. Badreddine J, Rabouille Y, Heron JF, et al (1993) Ovarian tumor with hepatoid differentiation. Discussion and review of the literature. Report of a case. Ann Pathol 13:37–39

    CAS  PubMed  Google Scholar 

  37. Scurry JP, Brown RW, Jobling T (1996) Combined ovarian serous papillary and hepatoid carcinoma. Gynecol Oncol 63:138–142

    Article  CAS  PubMed  Google Scholar 

  38. Matsuta M, Ishikura H, Murakami K, et al (1991) Hepatoid carcinoma of the ovary: a case report. Int J Gynecol Pathol 10:302–310

    CAS  PubMed  Google Scholar 

  39. Tochigi N, Kishimoto T, Supriatna Y, et al (2003) Hepatoid carcinoma of the ovary: a report of three cases admixed with a common surface epithelial carcinoma. Int J Gynecol Pathol 22:266–271

    PubMed  Google Scholar 

  40. Proks C, Feit V (1982) Gastric carcinoma with argyrophil and argentaffin cells. Virchows Arch A Pathol Anat Histol 395:201–206

    CAS  PubMed  Google Scholar 

  41. Lechago J (1994) Gastrointestinal neuroendocrine cell proliferations. Hum Pathol 25: 1114–1122

    Article  CAS  PubMed  Google Scholar 

  42. Nozue M, Nishida M, Todoroki T, et al (1991) Establishment and characterization of a human scirrhous type gastric cancer cell line, GCIY, producing CA19-9 (in Japanese). Hum Cell 4: 71–75

    CAS  PubMed  Google Scholar 

  43. Matsuda M, Watanabe A, Sawada H, et al (1999) Establishment of an α-fetoprotein-producing cell line derived from gastric cancer. In Vitro Cell Dev Biol Anim 35:555–557

    CAS  PubMed  Google Scholar 

  44. Sekiguchi M, Fujii Y, Saito A, et al (1995) Alpha-fetoprotein-producing gastric carcinoma: biological properties of a cultured cell line. J Gastroenterol 30:589–598

    CAS  PubMed  Google Scholar 

  45. Nakaya H, Ishizu A, Ikeda H, et al (2003) In vitro model of suicide gene therapy for alphafetoprotein-producing gastric cancer. Anticancer Res 23:3795–3800

    CAS  PubMed  Google Scholar 

  46. Warburton D, Wuenschell C, Flores-Delgado G, et al (1998) Commitment and differentiation of lung cell lineages. Biochem Cell Biol 76:971–995

    Article  CAS  PubMed  Google Scholar 

  47. Schrem H, Klempnauer J, Borlak J (2002) Liver-enriched transcription factors in liver function and development. Part I: The hepatocyte nuclear factor network and liver-specific gene expression. Pharmacol Rev 54:129–158

    Article  CAS  PubMed  Google Scholar 

  48. Schrem H, Klempnauer J, Borlak J (2004) Liver-enriched transcription factors in liver function and development. Part II: The C/EBPs and D site-binding protein in cell cycle control, carcinogenesis, circadian gene regulation, liver regeneration, apoptosis, and liver-specific gene regulation. Pharmacol Rev 56:291–330

    Article  CAS  PubMed  Google Scholar 

  49. Liu Y, Rao MS (2003) Transdifferentiation: fact or artifact. J Cell Biochem 88:29–40

    Article  CAS  PubMed  Google Scholar 

  50. Scarpelli DG, Rao MS (1981) Differentiation of regenerating pancreatic cells into hepatocyte-like cells. Proc Natl Acad Sci USA 78:2577–2581

    CAS  PubMed  Google Scholar 

  51. Rao MS, Subbarao V, Scarpelli DG (1988) Development of hepatocytes in the pancreas of hamsters treated with 2,3,7,8-tetrachlorodibenzo-p-dioxin. J Toxicol Environ Health 25: 201–205

    CAS  PubMed  Google Scholar 

  52. Shen CN, Horb ME, Slack JM, et al (2003) Transdifferentiation of pancreas to liver. Mech Dev 120:107–116

    Article  CAS  PubMed  Google Scholar 

  53. Combates NJ, Rzepka RW, Chen YN, et al (1994) NF-IL6, a member of the C/EBP family of transcription factors, binds and trans-activates the human MDR1 gene. J Biol Chem 269: 29715–29719

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular Pathology, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, Japan

    Hiroshi Ishikura, Yana Supriatna, Kazuhiro Kojima, Shigeyuki Kamata & Takashi Kishimoto

  2. Department of General Surgery, Chiba University Graduate School of Medicine, 1-8-1 Inohana, Chuo-ku, Chiba, Japan

    Kazuhiro Kojima & Shigeyuki Kamata

  3. Department of Gastroenterology and Hematology, Hokkaido University Graduate School of Medicine, Sapporo, Japan

    Hiroki Nakaya

Authors
  1. Hiroshi Ishikura
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Yana Supriatna
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Kazuhiro Kojima
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Shigeyuki Kamata
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hiroki Nakaya
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Takashi Kishimoto
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Departments of Gastrointestinal Surgery, Surgical Metabolic Care and Endocrine Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Michio Kaminishi M.D., Ph.D.

  2. Human Tissue Research Group, Tokyo Metropolitan Institute of Gerontology, 35-2 Sakaecho, Itabashi-ku, Tokyo, 173-0015, Japan

    Kaiyo Takubo M.D., Ph.D.

  3. Department of Gastrointestinal Surgery, The University of Tokyo Graduate School of Medicine, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Ken-ichi Mafune M.D., Ph.D., F.A.C.S.

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Springer-Verlag Tokyo

About this chapter

Cite this chapter

Ishikura, H., Supriatna, Y., Kojima, K., Kamata, S., Nakaya, H., Kishimoto, T. (2005). Hepatoid Adenocarcinoma of the Stomach: Biological Significance of Hepatic Transdifferentiation in Adenocarcinoma Cells. In: Kaminishi, M., Takubo, K., Mafune, Ki. (eds) The Diversity of Gastric Carcinoma. Springer, Tokyo. https://doi.org/10.1007/4-431-27713-7_10

Download citation

  • DOI: https://doi.org/10.1007/4-431-27713-7_10

  • Publisher Name: Springer, Tokyo

  • Print ISBN: 978-4-431-21139-6

  • Online ISBN: 978-4-431-27713-2

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation