Summary
A 60 year-old man with atherosclerosis obliterans had received a bypass operation twice, but came to notice resting pain in the left calf. As it was not possible to perform further bypass operations (resulys of arteriography), we conducted conservative treatments. We therefore performed therapeutic angiogenesis by autologous transplantation of bone marrow mononuclear cells since the symptoms were not improved at all. Resting pain was improved the next day after the operation and completely disappeared on the third day. The patient was only able to walk 180m in the preoperative state by crutch-assisted, but walked 180m without a stick on the second day and 900m on the fourth day. This treatment did not cause any inconvenience in everyday life and the patient showed no resting pain eight weeks later. In addition, the ankle-brachial index improved to 0.48 from the preoperation level of 0.36 after two months.
Therapeutic angiogenesis by autologous transplantation of bone marrow mononuclear cells was very useful.
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© 2005 Springer-Verlag Tokyo
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Fujimoto, K. et al. (2005). Therapeutic Angiogenesis for a Patient with Arteriosclerosis Obliterans by Autologous Transplantation of Bone Marrow Mononuclear Cells. In: Mori, H., Matsuda, H. (eds) Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches. Springer, Tokyo. https://doi.org/10.1007/4-431-27378-6_19
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DOI: https://doi.org/10.1007/4-431-27378-6_19
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-23925-3
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