Summary
Atherosclerosis is responsible for more than half of all deaths in western countries. Numerous studies have reported that exuberant accumulation of smooth muscle cells play a principal role in the pathogenesis of vascular diseases. It has been assumed that smooth muscle cells derived from the adjacent medial layer migrate, proliferate and synthesize extracellular matrix. Although much effort has been devoted, targeting migration and proliferation of medial smooth muscle cells, no effective therapy to prevent occlusive vascular remodeling has been established. Recently, we reported that bone marrow cells substantially contribute to the pathogenesis of vascular diseases, in models of post-angioplasty restenosis, graft vasculopathy and hyperlipidemia-induced atherosclerosis. It was suggested that bone marrow cells may have the potential to give rise to vascular progenitor cells that home in the damaged vessels and differentiate into smooth muscle cells or endothelial cells, thereby contributing to vascular repair, remodeling, and lesion formation. This article overviews recent findings on circulating vascular precursors and describes potential therapeutic strategies for vascular diseases, targeting mobilization, homing, differentiation and proliferation of circulating progenitor cells.
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References
Asahara T, Murohara T, Sullivan A, Silver M, van der Zee R, Li T, Witzenbichler B, Schatteman G, Isner JM (1997) Isolation of putative progenitor endothelial cells for angiogenesis. Science 275:964–967
Billingham ME (1987) Cardiac transplant atherosclerosis. Transplant Proc 19:19–25
Blau H M, Brazelton T R, Weimann J M (2001) The evolving concept of a stem cell: entity or function? Cell 105:829–841
Campbell J H, Tachas G, Black M J, Cockerill G, Campbell G R (1991) Molecular biology of vascular hypertrophy. Basic Res Cardiol 86:3–11
Grimm P C, Nickerson P, Jeffery J, Savani R C, Gough J, McKenna R M, Stern E, Rush D N (2001) Neointimal and tubulointerstitial infiltration by recipient mesenchymal cells in chronic renal-allograft rejection. N Engl J Med 345:93–97
Hill J M, Zalos G, Halcox J P, Schenke W H, Waclawiw M A, Quyyumi A A, Finkel T (2003) Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 348:593–600
Hillebrands J L, Klatter F A, van Den Hurk, B M, Popa E R, Nieuwenhuis P, Rozing J (2001) Origin of neointimal endothelium and alpha-actin-positive smooth muscle cells in transplant arteriosclerosis. J Clin Invest 107:1411–1422
Hu Y, Davison F, Ludewig B, Erdel M, Mayr M, Url M, Dietrich H, Xu Q (2002) Smooth muscle cells in transplant atherosclerotic lesions are originated from recipients, but not bone marrow progenitor cells. Circulation 106:1834–1839
Kaushal S, Amiel G E, Guleserian K J, Shapira O M, Perry T, Sutherland F W, Rabkin E, Moran A M, Schoen F J, Atala A, Soker S, Bischoff J, Mayer J E, Jr (2001) Functional small-diameter neovessels created using endothelial progenitor cells expanded ex vivo. Nat Med 7:1035–1040
Reya T, Morrison S J, Clarke M F, Weissman I L (2001) Stem cells, cancer, and cancer stem cells. Nature 414:105–111
Ross R (1999) Atherosclerosis-An inflammatory disease. N Eng J Med 340:115–126
Ross R (1993) The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature 362:801–809
Saiura A, Sata M, Washida M, Sugawara Y, Hirata Y, Nagai R, Makuuchi M (2003) Little evidence for cell fusion between recipient and Donor-Derived cells. J Surg Res 113:222–227
Saiura A, Sata M, Hirata Y, Nagai R, Makuuchi M (2001) Circulating smooth muscle progenitor cells contribute to atherosclerosis. Nat Med 7:382–383
Sata M (2003) Circulating vascular progenitor cells contribute to vascular repair, remodeling, and lesion formation. Trends Cardiovasc Med 13:249–253
Sata M, Tanaka K, Ishizaka N, Hirata Y, Nagai R (2003) Absence of p53 Leads to Accelerated Neointimal Hyperplasia After Vascular Injury. Arterioscler Thromb Vasc Biol 23:1548–1552
Sata M, Saiura A, Kunisato A, Tojo A, Okada S, Tokuhisa T, Hirai H, Makuuchi M, Hirata Y, Nagai R (2002) Hematopoietic stem cells differentiate into vascular cells that participate in the pathogenesis of atherosclerosis. Nat Med 8:403–409
Sata M, Sugiura S, Yoshizumi M, Ouchi Y, Hirata Y, Nagai R (2001) Acute and chronic smooth muscle cell apoptosis after mechanical vascular injury can occur independently of the Fas-death pathway. Arterioscler Thromb Vasc Biol 21:1733–1737
Sata M, Maejima Y, Adachi F, Fukino K, Saiura A, Sugiura S, Aoyagi T, Imai Y, Kurihara H, Kimura K, Omata M, Makuuchi M, Hirata Y., Nagai R (2000) A mouse model of vascular injury that induces rapid onset of medial cell apoptosis followed by reproducible neointimal hyperplasia. J Mol Cell Cardiol 32:2097–2104
Shimizu K, Sugiyama S, Aikawa M, Fukumoto Y, Rabkin E, Libby P, Mitchell R N (2001) Host bone-marrow cells are a source of donor intimal smooth-muscle-like cells in murine aortic transplant arteriopathy. Nat Med 7:738–741
Simper D, Stalboerger P G, Panetta C J, Wang S, Caplice N M (2002) Smooth muscle progenitor cells in human blood. Circulation 106:1199–1204
Tanaka K, Sata M, Hirata Y, Nagai R (2003) Diverse contribution of bone marrow cells to neointimal hyperplasia after mechanical vascular injuries. Circ Res 93:783–790
Terada N, Hamazaki T, Oka M, Hoki M, Mastalerz D M, Nakano Y, Meyer E M, Morel L, Petersen B E, Scott E W (2002) Bone marrow cells adopt the phenotype of other cells by spontaneous cell fusion. Nature 416:542–545
Tricot O, Mallat Z, Heymes C, Belmin J, Leseche G, Tedgui A (2000) Relation between endothelial cell apoptosis and blood flow direction in human atherosclerotic plaques. Circulation 101:2450–2453
Wang X, Willenbring H, Akkari Y, Torimaru Y, Foster M, Al-Dhalimy M, Lagasse E, Finegold M, Olson S, Grompe M (2003) Cell fusion is the principal source of bone-marrow-derived hepatocytes. Nature 422:897–901
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© 2005 Springer-Verlag Tokyo
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Sata, M., Nagai, R. (2005). Vascular Regeneration and Remodeling by Circulating Progenitor Cells. In: Mori, H., Matsuda, H. (eds) Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches. Springer, Tokyo. https://doi.org/10.1007/4-431-27378-6_10
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DOI: https://doi.org/10.1007/4-431-27378-6_10
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-23925-3
Online ISBN: 978-4-431-27378-3
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