Summary
The isolation of endothelial progenitor cells (EPCs) derived from bone marrow (BM) was an outstanding event in the recognition of ‘de novo vessel formation’ in adults occurring as physiological and pathological responses. The finding that EPCs migrate to sites of neovascularization and differentiate into endothelial cells (ECs) in situ is consistent with “vasculogenesis”, a critical paradigm that is well described for embryonic neovascularization, but proposed recently in adults in which a reservoir of stem or progenitor cells contribute to vascular organogenesis. EPCs have also been considered as therapeutic agents to supply the potent origin of neovascularization under pathological conditions. This review highlights an update of EPC biology as well as their potential use for therapeutic regeneration.
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References
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© 2005 Springer-Verlag Tokyo
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Iwaguro, H., Takayuki, A. (2005). EPC and Their Potentiation by Adenovirus Gene Delivery. In: Mori, H., Matsuda, H. (eds) Cardiovascular Regeneration Therapies Using Tissue Engineering Approaches. Springer, Tokyo. https://doi.org/10.1007/4-431-27378-6_1
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DOI: https://doi.org/10.1007/4-431-27378-6_1
Publisher Name: Springer, Tokyo
Print ISBN: 978-4-431-23925-3
Online ISBN: 978-4-431-27378-3
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