Skip to main content
SpringerLink
Log in

Phosphate transport in the kidney

  • Chapter
  • First Online:
Reviews of Physiology, Biochemistry and Pharmacology, Volume 100

Part of the book series: Reviews of Physiology, Biochemistry and Pharmacology ((REVIEWS,volume 100))

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Albright F, Reifenstein EC Jr (1948) The parathyroid glands and metabolic bone disease. Williams & Wilkins, Baltimore

    Google Scholar 

  • Aldred JP, Stubbs RK, Hermann WR, Zeedyr RA, Bastian JW (1970a) Effects of porcine calcitonin on some urine electrolytes on the rat. Acta Endocrinol 65:737–750

    Google Scholar 

  • Aldred JP, Kleszynski RR, Bastian JW (1970b) Effects of acute administration of porcine and salmon calcitonin on urine electrolyte excretion in rats. Proc Soc Exp Biol Med 134:1175–1180

    Google Scholar 

  • Amiel C (1980) Sites of renal tubular reabsorption of phosphate. In: Massry SG, Fleisch H (eds) Renal handling of phosphate. Plenum Medical, New York, pp 39–57

    Google Scholar 

  • Amiel C, Kuntziger H, Richet G (1970) Micropuncture study of handling of phosphate by proximal and distal nephron in normal and parathyroidectomized rat. Evidence for distal reabsorption. Pflügers Arch 317:93–109

    Google Scholar 

  • Amiel C, Kuntziger H, Couette S, Coureau C, Bergounioux N (1976) Evidence for a parathyroid hormone-independent calcium modulation of phosphate transport along the nephron. J Clin Invest 57:256–263

    Google Scholar 

  • Avioli LV (1980) Effects of vitamin D and its metabolites on renal handling of phosphate. In: Massry SG, Fleisch H (eds) Renal handling of phosphate. Plenum, New York, pp 197–207

    Google Scholar 

  • Avioli LV, Bordier P, Fleisch H, Massry S, Slatopolsky E (1976) Phosphate metabolism, kidney and bone. In: International workshop, Laboratoire Armour-Montagu, Paris, June 1975

    Google Scholar 

  • Bank N, Su WS, Aynedjian HS (1978) A micropuncture study of renal phosphate transport in rats with chronic renal failure and secondary hyperparathyroidism. J Clin Invest 61:884–894

    Google Scholar 

  • Barlet JP (1972) Effect of porcine, salmon and human calcitonin on urinary excretion of some electrolytes in sheep. J Endocrinol 55:153–161

    Google Scholar 

  • Barrett PQ, Gertner JM, Rasmussen H (1980) Effect of dietary phosphate on transport properties of pig renal microvillus vesicles. Am J Physiol 239:F352–F359

    Google Scholar 

  • Baumann K, De Rouffignac C, Roinel N, Rumrich G, Ullrich KJ (1975) Renal phosphate transport: inhomogeneity of local proximal transport rates and sodium dependence. Pflügers Arch 356:287–297

    Google Scholar 

  • Beck N (1976) Effects of dietary phosphorus (P) intake on renal actions of parathyroid hormone (PTH) and cyclic AMP (cAMP). Kidney Int 10:487

    Google Scholar 

  • Beck N (1981) Effect of a metabolic acidosis on renal response to parathyroid hormone in phosphorus-deprived rats. Am J Physiol 241:F23–F27

    Google Scholar 

  • Beck N, Webster SK, Reineck HJ (1979) Effect of fasting on tubular phosphorus reabsorption. Am J Physiol 237:F241–F246

    Google Scholar 

  • Bengele HH, Lechene CP, Alexander EA (1979) Phosphate transport along the inner medullary collecting duct of the rat. Am J Physiol 237:F48–F54

    Google Scholar 

  • Berndt TJ, Knox FG, Dousa TP (1981) Role of nicotine-adenine dinucleotide (NAD) in the phosphaturic response to parathyroid hormone (PTH). Kidney Int 19:108

    Google Scholar 

  • Berson SA, Yalow RS (1966) Parathyroid hormone in plasma in adenomatous hyperparathyroidism, uremia, and bronchogenic carcinoma. Science 154:907–909

    Google Scholar 

  • Biber J, Scalera V, Murer H (1982) Phosphorylation of rat kidney brush border membrane proteins under “physiological” conditions. In: Morel F (ed) Inserm Symposium no. 21. Biochemistry of kidney functions. Elsevier, Amsterdam, pp 385–390

    Google Scholar 

  • Bijvoet OLM (1976) The importance of the kidneys in phosphate homeostasis. In: Avioli L, Bordier P, Fleisch H, Massry S, Slatopolsky E (eds) Phosphate metabolism, kidney and bone. Armour Montagu, Paris, pp 421–474

    Google Scholar 

  • Bijvoet OLM, Morgan DB, Fourman P (1969) The assessment of phosphate reabsorption. Clin Chim Acta 26:15–24

    Google Scholar 

  • Birge SJ (1981) intestinal phosphate transport and alkaline phosphatase. In: Bronner F, Peterlik M (eds) Phosphate transport across biomembranes. Wien Symposium 1981. Academic Press, London, pp 181–184

    Google Scholar 

  • Bommer J, Bonjour JP, Ritz E, Fleisch H. Bornand J (1979) Parathyroid-independent change in renal handling of phosphate in hyperthyroid rats. Kidney Int 15:325–334

    Google Scholar 

  • Bonjour JP, Fleisch H (1977) The effect of vitamin D and its metabolites on the renal handling of phosphate. In: Norma AW, Schaefer K, Coburn JW, DeLuca HF, Fraser D, Grigoleit HG, von Herrath D (eds) Vitamin D biochemical, chemical and clinical aspects related to calcium metabolism. de Gruyter, Berlin New York, pp 419–431

    Google Scholar 

  • Bonjour JP, Fleisch H (1980a) Tubular adaptation to the supply and requirement of phosphate. In: Massry SG, Fleisch H (eds) Renal handling of phosphate. Plenum Medical, New York, pp 243–264

    Google Scholar 

  • Bonjour JP, Fleisch H (1980b) Calcium supply and renal handling of phosphate. Miner Electrolyte Metab 3:261–267

    Google Scholar 

  • Bonjour JP, Preston C, Fleisch H (1977a) Effect of 1,25-dihydroxyvitamin D3 on the renal handling of Pi in thyroparathyroidectomized rats. J Clin Invest 60:1419–1428

    Google Scholar 

  • Bonjour JP, Fleisch H, Trechsel U (1977b) Calcium absorption in diphosphonate-treated rats: effect of parathyroid function, dietary calcium and phosphorus. J Physiol 264:125–137

    Google Scholar 

  • Bonjour JP, Troehler U, Preston C, Fleisch H (1978a) Parathyroid hormone and renal handling of Pi: effect of dietary Pi and diphosphonates. Am J Physiol 234:F497–F505

    Google Scholar 

  • Bonjour JP, Preston C, Rizzoli R, Fleisch H (1978b) Vitamin D metabolites and phosphate transport. In: Copp DH (ed) Endocrinology of calcium metabolism. Proceedings of the sixth parathyroid conference, Vancouver, Canada, June 12–17, 1977. Excerpta Medica, Amsterdam Oxford

    Google Scholar 

  • Bonjour JP, Caverzasio J, Mühlbauer R, Fleisch H, Trechsel U (1979a) Acute and chronic effects of Vitamin D metabolites on the renal handling of phosphate. In: Norman AW, Schaefer K, von Herrat D, Grigoleit HG (eds) Vitamin D, basic research and its clinical application. de Gruyter, Berlin New York

    Google Scholar 

  • Bonjour JP, Care AD, Pickard DW (1979b) Renal adaptation to changes in dietary phosphorus intake by thyroparathyroidectomized pigs. J Physiol 290:27–28

    Google Scholar 

  • Bonjour JP, Fleisch H (1980b) Calcium supply and renal handling of phosphate. Miner Electrolyte Metab 3:261–267

    Google Scholar 

  • Bonjour JP, Caverzasio J, Fleisch H, Mühlbauer R, Troehler U (1982a) The adaptive system of the tubular transport of phosphate. In: Massry SG, Letteri JM, Ritz E (eds) Regulation of phosphate and mineral metabolism. Plenum Press, New York London (Advances in experimental medicine and biology, vol 151, pp 1–11. Proc 5th Int workshop ion phosphate and other minerals, New York, 1981)

    Google Scholar 

  • Bonjour JP, Caverzasio J, Mühlbauer R, Trechsel U, Troehler U (1982b) Are 1,25-(OH)2D3 production and tubular phosphate transport regulated by one common mechanism which would be defective in X-linked hypophosphatemic rickets? In: Norman AW, Schaefer K, von Herrath D, Grigoleit HG (eds) Vitamin D, chemical, biochemical and clinical endocrinology of calcium metabolism. de Gruyter, Berlin New York, pp 427–433

    Google Scholar 

  • Borle AG (1972) Parathyroid hormone and cell calcium. In: Talmage RV, Munson PL (eds) Calcium, parathyroid hormone and the calcitonins. Excerpta Medica, Amsterdam (Proceedings of the fourth parathyroid conference, Chapel Hill, NC, March 15–19, 1971. International Congress Series No 243)

    Google Scholar 

  • Boudry JF, Troehler U, Touabi M, Fleisch H, Bonjour JP (1975) Secretion of inorganic phosphate in the rat nephron. Clin Sci Mol Med 48:475–489

    Google Scholar 

  • Brazy PC, McKeown JW, Harris RH, Dennis VW (1980a) Comparative effects of dietary phosphate, unilateral nephrectomy and parathyroid hormone on phosphate transport by the rabbit proximal tubule. Kidney Int 17:788–800

    Google Scholar 

  • Brazy PC, Balaban RS, Gullans SR, Mandel LJ, Dennis VW (1980b) Inhibition of metabolism: relative effects of arsenate on sodium, phosphate and glucose transport by the rabbit proximal tubule. J Clin Invest 66:1211–1221

    Google Scholar 

  • Bricker NS (1972) On the pathogenesis of the uremic state. An exposition of the “Trade-off Hypothesis”. N Engl J Med 286:1093–1099

    Google Scholar 

  • Bricker NS, Fine LG, Kaplan M, Epstein M, Bourgoignie JJ, Light A (1978) “Magnification phenomenon” in chronic renal disease. N Engl J Med 299:1287–1293

    Google Scholar 

  • Brickman AS, Coburn JW, Kurokawa K, Bethune JE, Harrison HE, Norman AW (1973) Actions of 1,25-dihydroxycholecalciferol in patients with hypophosphatemic, vitamin-D-resistant rickets. N Engl J Med 289:495–498

    Google Scholar 

  • Brunette MG, Beliveau R (1983) Brush border membrane from human kidney. Protein composition and phosphate uptake capacity. Kidney Int 23:96

    Google Scholar 

  • Brunette MG, Dennis VW (1982) Effects of L-bromotetramisole on phosphate transport by the proximal renal tubule: failure to demonstrate a direct involvement of alkaline phosphatase. Can J Physiol Pharmacol 60:276–281

    Google Scholar 

  • Brunette MG, Taleb L, Carriere S (1973) Effect of parathyroid hormone on phosphate reabsorption along the nephron of the rat. Am J Physiol 225:1076–1081

    Google Scholar 

  • Brunette MG, Chan M, Lebrun M (1981) Phosphatase activity along the nephron of mice with hypophosphatemic vitamin D resistant rickets. Kidney Int 20:181–187

    Google Scholar 

  • Burnatowska MA, Harris CA, Sutton RAL, Dirks JH (1977) Effects of PTH and cAMP on renal handling of calcium, magnesium and phosphate in the hamster. Am J Physiol 233:F514–F518

    Google Scholar 

  • Caverzasio J, Faundez R, Fleisch H, Bonjour JP (1981) Tubular adaptation to Pi restriction in hypophysectomized rats. Pflügers Arch 392:17–21

    Google Scholar 

  • Caverzasio J, Bonjour JP, Fleisch H (1982a) Phosphate transport in renal brush border membrane vesicles (BBMV): studies on regulation and mechanism. In: Morel F (ed) Biochemistry of kidney functions. INSERM symposium 21. Elsevier Biomedical, Amsterdam, pp 373–376

    Google Scholar 

  • Caverzasio J, Murer H, Fleisch H, Bonjour JP (1982b) Phosphate transport in brush border membrane vesicles isolated from renal cortex of young growing and adult rats. Comparison with whole kidney data. Pflügers Arch 394:217–221

    Google Scholar 

  • Caverzasio J, Bonjour JP, Fleisch H (1982c) Tubular handling of Pi in young growing and adult rats. Am J Physiol 242:F705–F710

    Google Scholar 

  • Caverzasio J, Gloor HJ, Fleisch H, Bonjour JP (1982d) Parathyroid hormone-independent adaptation of the renal handling of phosphate in response to renal mass reduction. Kidney Int 21:471–476

    Google Scholar 

  • Chambers EL, Gordan GS, Goldman L, Reifenstein C Jr (1956) Tests for hyperparathyroidism: tubular reabsorption of phosphate, phosphate deprivation and calcium infusion. J Clin Endocrinol Metab 16:1507–1521

    Google Scholar 

  • Cheng L, Sacktor B (1981) Sodium gradient-dependent phosphate transport in renal brush border membrane vesicles. J Biol Chem 256:1556–1564

    Google Scholar 

  • Cheng L, Liang CT, Sacktor B (1981) In vitro effects of parathyroid hormone on kidney cortical slices: cAMP responses and concomitant inhibition of the Na+ gradient-dependent uptake of phosphate by brush border membrane vesicles isolated from the renal slices. Endocr Res Commun 8:97–110

    Google Scholar 

  • Chesney RW (1983) Phosphaturic syndrome. In: Gonick H (ed) Renal tubular disorders. Dekker, New York (in press)

    Google Scholar 

  • Clark NB, Sasayama Y (1981) The role of parathyroid hormone on renal excretion of calcium and phosphate in the Japanese quail. Gen Comp Endocrinol 45:234–241

    Google Scholar 

  • Clark NB, Wideman RF (1977) Renal excretion of phosphate and calcium in parathyroidectomized starlings. Am J Physiol 233:F138–F144

    Google Scholar 

  • Clark NB, Dantzler WH (1972) Renal tubular transport of calcium and phosphate in snakes: role of parathyroid hormone. Am J Physiol 223:1455–1464

    Google Scholar 

  • Clark NB, Braun EJ, Wideman RF (1976) Parathyroid hormone and renal excretion of phosphate and calcium in normal starlings. Am J Physiol 231:1152–1158

    Google Scholar 

  • Coburn JW, Koppel MH, Brickman AS, Massry SG (1973) Study of intestinal absorption of calcium in patients with renal failure. Kidney Int 3:264–272

    Google Scholar 

  • Corvilain J, Abramow M (1962) Some effects of human growth hormone on renal hemodynamics and on tubular phosphate transport in man. J Clin Invest 41:1230–1235

    Google Scholar 

  • Corvilain J, Abramow M (1964) Effect on growth hormone on tubular transport of phosphate in normal and parathyroidectomized dogs. J Clin Invest 43:1608–1612

    Google Scholar 

  • Cowgill LD, Goldfarb S, Lau K, Slatopolsky E, Agus Z (1979) Evidence for an intrinsic renal tubular defect in mice with genetic hypophosphatemic rickets. J Clin Invest 63:1203–1210

    Google Scholar 

  • Crawford JD, Osborne MM Jr, Talbot NB, Terry LM, Morrill MF (1950) The parathyroid glands and phosphorus homeostasis. J Clin Invest 29:1448–1461

    Google Scholar 

  • Crawford JD, Gribetz D, Talbot NB (1955) Mechanism of renal tubular phosphate reabsorption and the influence thereon of vitamin D in completely parathyroidectomized rats. Am J Physiol 180:156–162

    Google Scholar 

  • Cuche JL, Ott CE, Marchand GR, Diaz-Buxo JA, Knox FG (1976) Intrarenal calcium in phosphate handling. Am J Physiol 230:790–796

    Google Scholar 

  • Davies M, Hill LF, Taylor CM, Stanbury SW (1977) 1,25 Dihydroxycholecalciferol in hypoparathyroidism. Lancet I:55–59

    Google Scholar 

  • Davis BB, Kedes LH, Field JB (1966) Demonstration of distal tubular flux of phosphorus using modified stop-flow analysis. Metabolism 15:482–491

    Google Scholar 

  • DeLuca HF, Schnoes HK (1976) Metabolism and mechanism of action of vitamine D. Annu Rev Biochem 45:631–666

    Google Scholar 

  • Dennis VW, Brazy PC (1982) Divalent anion transport in isolated renal tubules. Kidney Int 22:498–506

    Google Scholar 

  • Dennis VW, Woodhall PB, Robinson RR (1976) Characteristics of phosphate transport in isolated proximal tubule. Am J Physiol 231:979–985

    Google Scholar 

  • Dennis VW, Bello-Reuss E, Robinson RR (1977) Response of phosphate transport to parathyroid hormone in segments of rabbit nephron. Am J Physiol 233:F29–F38

    Google Scholar 

  • Dennis VW, Stead WW, Myers JL (1979) Renal handling of phosphate and calcium. Annu Rev Physiol 41:257–271

    Google Scholar 

  • De Rouffignac C, Bankir L, Roinel N (1981) Renal function and concentrating ability in a desert rodent: The Gundi (Ctenodactylus vali). Pflügers Arch 390:138–144

    Google Scholar 

  • Dousa T, Kempson SA (1982) Regulation of renal brush border membrane transport of phosphate. Miner Electrolyte Metab 7:113–121

    Google Scholar 

  • Drezner MK, Lyles KW, Haussler MR, Harrelson JM (1980) Evaluation of a role for 1,25-dihydroxyvitamin D3 in the pathogenesis and treatment of X-linked hypophosphatemic rickets and osteomalacia. J Clin Invest 66:1020–1032

    Google Scholar 

  • Egawa J, Neuman WF (1964) Effects of parathyroid extract on the metabolism of radioactive phosphate in kidney. Endocrinology 74:90

    Google Scholar 

  • Eisenberg E (1965) Effect of serum calcium level and parathyroid extracts on phosphate and calcium excretion in hypoparathyroid patients. J Clin Invest 44:942–946

    Google Scholar 

  • Engle JE, Steele T (1975) Renal phosphate reabsorption in the rat: Effect of inhibitors. Kidney Int 8:98–104

    Google Scholar 

  • Espinel CH (1975) Effect of proportional reduction of sodium intake on the adaptive increase in glomerular filtration rate/nephron and potassium and phosphate excretion in chronic renal failure in the rat. Clin Sci Mol Med 49:193–200

    Google Scholar 

  • Evanson JM (1966) The response to the infusion of parathyroid extract in hypocalcaemic states. Clin Sci 31:63–75

    Google Scholar 

  • Evers C, Murer H, Kinne R (1978) Effect of parathyrin on the transport properties of isolated renal brush-border vesicles. Biochem J 172:49–56

    Google Scholar 

  • Ferguson RK, Wolbach RA (1967) Effects of glucose, phlorizin and parathyroid extract on renal phosphate transport in chickens. Am J Physiol 212:1123–1130

    Google Scholar 

  • Fleisch H, Caverzasio J, Bonjour JP (1981) Regulation mechanisms of the renal phosphate handling in renal failure — what is the role of PTH? In: Massry SG, Letteri JM, Ritz E (eds) Regulation of phosphate and mineral metabolism. Advances in experimental medicine and biology, vol 151. Proc 5th Int workshop on phosphate and other minerals. Plenum Press, New York London

    Google Scholar 

  • Fotino S (1977) Phosphate excretion in chronic renal failure: evidence for a mechanism other than circulating parathyroid hormone. Clin Nephrol 8:499–503

    Google Scholar 

  • Freudiger H, Caverzasio J, Fischer J, Trechsel U, Bonjour JP (to be published) Urinary cyclic AMP and parathyroid hormone status in rats with intact and reduced renal mass.

    Google Scholar 

  • Frick A (1968) Reabsorption of inorganic phosphate in the rat kidney: I. Saturation of transport mechanism. II. Suppression of fractional phosphate reabsorption due to expansion of extracellular fluid volume. Pflügers Arch 304:351–364

    Google Scholar 

  • Friedlaender MM, Kornberg Z, Wald H, Popovtzer MM (1983) Renal response to 1a(OH)vitamin D3 and 24,25(OH)2D3. Evidence of the essenrial role of 25 (OH) group. Am J Physiol 244:F674–F678

    Google Scholar 

  • Gabbiani G, Tuchweber B, Cote G, Lefort P (1968) Action of thyroxine and calcitonin on experimental soft tissue calcification. Calcif Tissue Res 2:30–37

    Google Scholar 

  • Garabedian M, Holick MF, DeLuca HF, Boyle IT (1972) Control of 25-hydroxychole-calciferol metabolism by parathyroid gland. Proc Natl Acad Sci USA 69:1673–1676

    Google Scholar 

  • Geary CP, Cousin FB (1971) Effect of parathyroid extract and glycerol on 32P uptake in rat renal tissue. Aust J Exp Biol Med Sci 49:463

    Google Scholar 

  • Giasson SD, Brunette MG, Danan G, Vigneault N, Carriere S (1977) Micropuncture study of renal phosphorus transport in hypophosphatemic vitamin D resistant rickets mice. Pflügers Arch 371:33–38

    Google Scholar 

  • Ginn HE, Shanbour LL (1967) Phosphaturia in magnesium-deficient rats. Am J Physiol 212:1347

    Google Scholar 

  • Gloor HJ, Bonjour JP, Caverzasio J, Fleisch H (1979) Resistance to the phosphaturic and calcemic actions of parathyroid hormone during phosphate depletion prevention by 1,25-dihydroxyvitamin D3. J Clin Invest 63:371–377

    Google Scholar 

  • Glorieux FH, Scriver CR (1972) Loss of parathyroid hormone-sensitive component of phosphate transport in X-linked hypophosphatemia. Science 175:997–1000

    Google Scholar 

  • Glorieux FH, Scriver CR, Holick MF, DeLuca HF (1973) X-Linked hypophosphatemic rickets: inadequate therapeutic response to 1,25-dihydroxycholecalciferol. Lancet II:287–289

    Google Scholar 

  • Glorieux FH, Marie PJ, Pettifor JM, Delvin EE (1980) Bone response to phosphate salts, ergocalciferol, and calcitriol in hypophosphatemic vitamin D-resistant rickets. N Engl J Med 303:1023–1031

    Google Scholar 

  • Golberg M, Agus ZS, Goldfarb S (1976) Renal handling of calcium and phosphate. Int Rev Physiol 11:211–256

    Google Scholar 

  • Goldfarb S (1980) Juxtamedullary and superficial nephron phosphate reabsorption in the cat. Am J Physiol 239:F336–F342

    Google Scholar 

  • Goldfarb S, Bosanac P, Goldberg M, Agus ZS (1978) Effects of calcium on renal tubular phosphate reabsorption. Am J Physiol 234:F22–F28

    Google Scholar 

  • Goldman R, Bassett SH (1954) Phosphorus excretion in renal failure. J Clin Invest 33:1623–1628

    Google Scholar 

  • Grafflin AL (1936) Renal function in marine teleosts. Biol Bull 71:360–374

    Google Scholar 

  • Gray RW, Wilz DR, Caldas AE, Lemann J Jr (1977) The importance of phosphate in regulating plasma 1,25-(OH)2-vitamin D levels in humans: Studies in healthy subjects, in calcium-stone formers and in patients with primary hyperparathyroidism. J Clin Endocrinol Metab 45:229–306

    Google Scholar 

  • Greger R, Lang F, Marchand G, Knox FG (1977) Site of renal phosphate reabsorption. Micropuncture and microinfusion study. Pflügers Arch 369:111–118

    Google Scholar 

  • Haas JA, Berndt TJ, Knox FG (1982) Nephron site of action of nicotinamide on phosphate reabsorption. Kidney Int 21:133

    Google Scholar 

  • Hammerman MR, Hruska KA (1982) Cyclic AMP dependent protein phosphorylation in canine renal brush border membrane vesicles is associated with decreased phosphate transport. J Biol Chem 257:992–999

    Google Scholar 

  • Hammerman MR, Hansen VA, Morrissey JJ (1982) ADP ribosylation of canine renal brush border membrane vesicle proteins is associated with decreased phosphate transport. J Biol Chem 257:12380–12386

    Google Scholar 

  • Hammerman MR, Cohn DE, Tamayo J, Martin KJ (1983) PTH increases ADP-ribosylation of canine renal brush border membrane proteins. Kidney Int 23:100

    Google Scholar 

  • Haramati A, Knox FG (1981) Is phosphate reabsorbed by the distal nephron? Miner Electrolyte Metab 6:165–173

    Google Scholar 

  • Haramati A, Knox FG (1983) Tubular capacity of phosphate transport in phosphatedeprived rats: effects of nicotinamide and PTH. Am J Physiol 244:F178–F184

    Google Scholar 

  • Haramati A, Haas JA, Knox FG (1982) Adaptation of deep and superficial nephrons to changes in dietary phosphate intake. Kidney Int 21:134

    Google Scholar 

  • Harris CA, Seely JF (1979) Resistance to the phosphaturic effect of PTH in the hamster. Am J Physiol 237:F175–F181

    Google Scholar 

  • Harris CA, Burnatowska MA, Seely JF, Sutton RAL, Quamme GA, Dirks JH (1979) Effects of parathyroid hormones on electrolyte transport in the hamster nephron. Am J Physiol 236:F342–F348

    Google Scholar 

  • Harter HR, Mercado A, Rutherford E, Rodriguez H, Slatopolsky E, Klahr S (1974) Effect of phosphate depletion and parathyroid hormone on renal glucose reabsorption. Am J Physiol 227:1422–1427

    Google Scholar 

  • Hernandez T, Coulson RA (1956) Renal clearance in the alligator. Fed Proc 15:91

    Google Scholar 

  • Hioco DJ (1971) Phosphate et métabolisme phosphocalcique. Regulation normale et aspects physiopathologiques. International symposium, Octobre 1970, Paris. Sandoz, Paris

    Google Scholar 

  • Hoffmann N, Thees M, Kinne R (1976) Phosphate transport by isolated renal brush border vesicles. Pflügers Arch 362:147–156

    Google Scholar 

  • Holt WF, Lechene C (1981) ADH-PGE2 interactions in cortical collecting tubule. II. Inhibition of Ca and P reabsorption. Am J Physiol 241:F461–F467

    Google Scholar 

  • Hoppe A, Destro M, Knox FG (1980) Effect of NH4Cl on phosphaturic response to PTH in the hamster: dissociation from acidemia. Am J Physiol 239:E328–E332

    Google Scholar 

  • Hruska KA, Hammerman MR (1981) Parathyroid hormone inhibition of phosphate transport in renal brush border membrane vesicles from phosphate depleted dogs. Biochim Biophys Acta 645:351–356

    Google Scholar 

  • Hruska KA, Klahr S, Hammerman MR (1982) Decreased luminal membrane transport of phosphate in chronic renal failure. Am J Physiol 242:F17–F22

    Google Scholar 

  • Hughes MR, Brumbaugh PF, Haussler MR (1975) Regulation of serum 1a,25-dihydroxyvitamin D3 by calcium and phosphate in the rat. Science 190:578–579

    Google Scholar 

  • Hugi K, Bonjour JP, Fleisch H (1979) Renal handling of calcium: influence of parathyroid hormone and 1,25-dihydroxyvitamin D3. Am J Physiol 236:F349–F356

    Google Scholar 

  • Insogna KL, Broadus A, Gertner JM (1983) Impaired phosphorus conservation and 1,25-dihydroxyvitamin D generation during phosphorus deprivation in familial hypophosphatemic rickets. J Clin Invest 71:1562–1569

    Google Scholar 

  • Jamison RL, Arrascue JF (1980) Calcium and phosphorus reabsorption by the loop of Henle. Miner Electrolyte Metab 4:97–105

    Google Scholar 

  • Kaplan MA, Canterbury JM, Gavellas G, Jaffe D, Bourgoignie JJ, Riess E, Bricker NS (1978) The calcemic and phosphaturic effects of parathyroid hormone in the normal and uremic dog. Metabolism 27:1785–1792

    Google Scholar 

  • Kempson SA, Kim JK, Northrup TE, Knox FG, Dousa TP (1979) Alkaline phosphatase in adaptation to low dietary phosphate intake. Am J Physiol 237:E465–E473

    Google Scholar 

  • Kempson SA, Shah SV, Werness PG, Berndt T, Lee PH, Smith LH, Knox FG, Dousa TP (1980) Renal brush border membrane adaptation to phosphorus deprivation: Effects of fasting versus low-phosphorus diet. Kidney Int 18:36–47

    Google Scholar 

  • Kempson SA, Colon-Otero G, Ou SYL, Turner ST, Dousa TP (1981) Possible role of nicotinamide adenine dinucleotide as an intracellular regulator of renal transport of phosphate in the rat. J Clin Invest 67:1347–1360

    Google Scholar 

  • Kessler RJ, Fanestil DD (1981) Identification of a phosphate-binding proteolipid in kidney brush border. In: Bronner F, Peterlik M (eds) Calcium and phosphate transport across biomembranes. Academic Press, New York, pp 123–126

    Google Scholar 

  • Kiebzak GM, Roos BA, Meyer RA Jr (1982) Secondary hyperparathyroidism in X-linked hypophosphatemic mice. Endocrinology 111:650–652

    Google Scholar 

  • Kinne R (1978) Current concepts of renal proximal tubular function. Contr Nephrol 14:14–24

    Google Scholar 

  • Kinne R, Schlatz LJ, Kinne-Saffran E, Schwartz IL (1975) Distribution of membrane bound cyclic AMP dependent protein kinase in plasma membranes of cells of the kidney cortex. J Membr Biol 24:145–159

    Google Scholar 

  • Klahr S, Morrissey J, Hruska K (1982) Effect of parathyroid hormone on phospholipid metabolism. In: Massry SG, Letteri JM, Ritz E (eds) Regulation of phosphate and mineral metabolism. Proc 5th Int workshop on phosphate and other minerals, New York, 1981. Plenum Press, New York (Advances in experimental medicine and biology, vol 151)

    Google Scholar 

  • Knox FG, Haramati A (1984) Renal regulation of phosphate excretion. In: Seldin DW, Giebisch G (eds) Physiology and pathology of electrolyte metabolism. Raven Press, New York

    Google Scholar 

  • Knox FG, Osswald H, Marchand GR, Spielman WS, Haas JA, Berndt T, Youngberg SP (1977a) Phosphate transport along the nephron. Am J Physiol 233:261–268

    Google Scholar 

  • Knox FG, Haas JA, Berndt T, Marchand GR, Youngberg SP (1977b) Phosphate transport in superficial and deep nephrons in phosphate-loaded rats. Am J Physiol 233:F150–F153

    Google Scholar 

  • Knox FG, Preiss J, Kim JK, Dousa TP (1977c) Mechanism of resistance to the phosphaturic effect of the parathyroid hormone in the hamster. J Clin Invest 59:675–683

    Google Scholar 

  • Knox FG, Czekalski S, Dousa TP (1981) Cellular mechanisms of action of parathyroid hormone on phosphate transport in the renal proximal tubule. In: Bronner F, Peterlik M (eds) Calcium and phosphate transport across biomembranes. Academic Press, New York, pp 247–250

    Google Scholar 

  • Knox FG, Haas JA, Haramati A (1982) Nephron sites of adaptation to changes in dietary phosphate. In: Massry SG, Letteri JM, Ritz E (eds) Regulation of phosphate and mineral metabolism. Proc 5th Int workshop on phosphate and other minerals, New York, 1981. Plenum Press, New York (Advances in experimental medicine and biology, vol 151)

    Google Scholar 

  • Koide Y, Kugai N, Jamashita K, Shimazawa E, Ogata E (1976) A transient increase in renal clearance of phosphate in response to continuous infusion of salmon calcitonin in rats. Endocrinol Jpn 23:295–304

    Google Scholar 

  • Kreusser WJ, Kurokawa K, Aznar E, Massry SG (1978) Phosphate depletion. Miner Electrolyte Metab 1:30–42

    Google Scholar 

  • Kreusser WJ, Descoeudres C, Oda Y, Massry SG (1980) Effect of phosphate depletion on renal gluconeogenesis. Miner Electrolyte Metab 3:312–322

    Google Scholar 

  • Kurokawa K, Kreusser WJ, Aznar E, Sachtjen E, Massry SG (1980) Effect of parathyroid hormone and calcitonin on renal cyclic AMP and protein kinase activity during phosphate depletion. Miner Electrolyte Metab 4:197–202

    Google Scholar 

  • Lang F (1980) Renal handling of calcium and phosphate. Klin Wochenschr 58:985–1003

    Google Scholar 

  • Lang RP, Yanagawa N, Nord E, Fine LG (1983) Nucleotides competitively inhibit Na-dependent phosphorus (P) uptake by brush border membrane (BBM) of rabbit proximal tubules. Kidney Int 23:103

    Google Scholar 

  • Lau K, Goldfarb S, Goldberg M (1980) The effects of parathyroid hormone on renal phosphate handling. In: Massry SG, Fleisch H (eds) Renal handling of phosphate. Plenum Press, New York, pp 115–135

    Google Scholar 

  • Lavender AR, Pullman TN (1963) Changes in inorganic phosphate excretion induced by renal arterial infusion of calcium. Am J Physiol 205:1025–1032

    Google Scholar 

  • Laverty G, Clark NB (1981) Renal clearance of phosphate and calcium in the freshwater turtle: Effects of parathyroid hormone. J Comp Physiol 141:463–469

    Google Scholar 

  • Lee DBN, Brautbar N, Walling MW, Silis V, Carlson HE, Grindeland RE, Coburn JW, Kleeman CR (1980) Role of growth hormone in experimental phosphorus deprivation in the rat. Calcif Tissue Int 32:105–112

    Google Scholar 

  • Le Grimellec C (1975) Micropuncture study along the proximal convoluted tubule. Electrolyte reabsorption in first convolutions. Pflügers Arch 354:133–150

    Google Scholar 

  • Lemann J, Maierhofer WJ, Adams ND, Gray RW (1982) Increased serum 1,25-(OH)2-vitamin D concentrations fail to affect serum or urine phosphate in humans. Proceedings of the 5th International Workshop on Phosphates and other Minerals, September 1981. Adv Exp Med Biol 151:375–383

    Google Scholar 

  • Letellier M, Plante GE, Briere N, Petitclerc C (1982) Participation of alkaline phosphatase in the active transport of phosphates in brush border membrane vesicles. Biochem Biophys Res Commun 108:1394–1400

    Google Scholar 

  • Levine BS, Brautbar N, Coburn JW (1978) Does vitamin D affect the renal handling of calcium and phosphorus? Miner Electrolyte Metab 1:295–302

    Google Scholar 

  • Levine BS, Hodsman A, Shaw HF, Ho K, Kippin I, Hirayama B, Coburn JW (1981) Early renal adaptation to dietary phosphate restriction: the role of alkaline phosphatase. In: Cohn DV, Talmage RV, Matthews JL (eds) Hormonal control of calcium metabolism. Proceedings of the seventh international conference on calcium regulating hormones, Estes Park, Colorado, September 1980. Excerpta Medica, Amsterdam, p 434

    Google Scholar 

  • Levinsky NG, Davidson DG (1957) Renal action of a parathyroid extract in the chicken. Am J Physiol 191:530–536

    Google Scholar 

  • Liang CT, Barnes J, Cheng L, Balakir R, Sacktor B (1982a) Effects of 1,25-(OH)2D3 administered in vivo on phosphate uptake by isolated chick renal cells. Am J Physiol 242:C312–C318

    Google Scholar 

  • Liang CT, Barnes J, Balakir R, Cheng L, Sacktor B (1982b) In vitro stimulation of phosphate uptake in isolated chick renal cells by 1,25-dihydroxycholecalciferol. Proc Natl Acad Sci USA 79:3532–3536

    Google Scholar 

  • Lufkin EG, Wilson EM, Smith LH, Bill NJ, DeLuca HF, Dousa TP, Knox FG (1980) Phosphorus excretion in tumoral calcinosis: Response to parathyroid hormone and acetazolamide. J Clin Endocrinol 50:648–653

    Google Scholar 

  • Marshall EK, Grafflin AL (1933) Excretion of inorganic phosphate by the algomerular kidney. Proc Soc Exp Biol Med 31:41–46

    Google Scholar 

  • Martindale L (1973) Phosphate excretion in the laying hen. J Physiol 231:439–453

    Google Scholar 

  • Massry SG (1982) Secondary hyperparathyroidism of renal failure, evidence for a multifactorial pathogenesis. In: Zurkzoglu W, Papadimitriou M, Pyrpasopoulos M, Sion M, Zamboulis C (eds) Proceedings of the 8th international congress of nephrology, Athens, June 1981. Karger, Basel, pp 245–251

    Google Scholar 

  • Massry SG, Fleisch H (1980) Renal handling of phosphate. Plenum Medical, New York London

    Google Scholar 

  • Massry SG, Ritz E (1976) Phosphate metabolism. In: Proc 2nd Int Workshop on Phosphate, Heidelberg, Germany, 1976. Plenum Press, New York London (Advances in experimental medicine and biology, vol 81)

    Google Scholar 

  • Massry SG, Friedler R, Coburn JW (1973a) Excretion of phosphate and calcium, physiology of their renal handling and relation to clinical medicine. Arch Intern Med 131:838–859

    Google Scholar 

  • Massry SG, Coburn JW, Lee DBN, Jowsey J, Kleeman CR (1973b) Skeletal resistance to parathyroid hormone in renal failure. Ann Intern Med 78:357–364

    Google Scholar 

  • Massry SG, Arieff AI, Coburn JW, Palmieri G, Kleeman CR (1974) Divalent ion metabolism in patients with acute renal failure: Studies on the mechanism of hypocalcemia. Kidney Int 5:437–445

    Google Scholar 

  • Massry SG, Stein R, Garty J, Arieff AI, Coburn JW, Normal AW, Friedler RM (1976) Skeletal resistance to the calcemic action of parathyroid hormone in uremia: Role of 1,25(OH)2D3. Kidney Int 9:467–474

    Google Scholar 

  • Massry SG, Ritz E, Rapado A (1978a) Homeostasis of phosphate and other minerals. In: 3rd Int workshop on phosphate and other minerals, Madrid, 1977. Plenum Press, New York London (Advances in experimental medicine and biology, vol 103)

    Google Scholar 

  • Massry SG, Dua S, Garty J, Friedler RM (1978b) Role of uremia in the skeletal resistance to the calcemic action of parathyroid hormone. Miner Electrolyte Metab 1:172

    Google Scholar 

  • Massry SG, Tuma S, Dua S, Goldstein DA (1979) Reversal of skeletal resistance to parathyroid hormone in uremia by vitamin D metabolites. J Lab Clin Med 94:152–157

    Google Scholar 

  • Massry SG, Ritz E, Jahn H (1980) Phosphate and minerals in heath and disease. In: Proc 4th Int workshop on phosphate and other minerals, Strasbourg, 1979. Plenum Press, New York London (Advances in experimental medicine and biology, vol 128)

    Google Scholar 

  • Massry SG, Letteri JM, Ritz E (1982) Regulation of phosphate and mineral metabolism. In: Proc 5th Int workshop on phosphate and other minerals, New York 1981. Plenum Press, New York London (Advances in experimental medicine and biology, vol 151)

    Google Scholar 

  • McKeown JW, Brazy PC, Dennis VW (1979) Intrarenal heterogeneity for fluid, phosphate, and glucose absorption in the rabbit. Am J Physiol 237:F312–F318

    Google Scholar 

  • Melani F, Ramponi G, Farnararo M, Coccuci E, Guerritore A (1967) Regulation by phosphate of alkaline phosphatase in rat kidney. Biochim Biophys Acta 138:411–420

    Google Scholar 

  • Meyer RA Jr, Gray RW, Meyer MH (1980) Abnormal vitamin D metabolism in the X-linked hypophosphatemic mouse. Endocrinology 107:1577–1581

    Google Scholar 

  • Milhaud G, Moukhtar MS (1966) Antagonistic and synergistic actions of thyrocalcitonin and parathyroid hormone on the levels of calcium and phosphate in the rat. Nature 211:1186–1187

    Google Scholar 

  • Milhaud G, Moukhtar MS, Cherian G, Parault AM (1966) Effect de l'administration de thyrocalcitonine sur les principaux paramètres du métabolisme du calcium du rat normal et thyroparathyroidectomisé. C R Acad Sci 262:511–514

    Google Scholar 

  • Mitnick PD, Goldfarb S, Slatopolsky E, Lemann J Jr, Gray RW, Agus ZS (1980) Calcium and phosphate metabolism in tumoral calcinosis. Ann Intern Med 92:482–487

    Google Scholar 

  • Morgan B (1973) Osteomalacia, renal osteodystrophy and osteoporosis. Thomas, Springfield, Ill

    Google Scholar 

  • Moser S, Brautbar N, Gura V, Kleeman CR, Massry SG (1981) On the mechanism of hypophosphaturia during acute and chronic dietary phosphate restriction. Miner Electrolyte Metab 5:39–48

    Google Scholar 

  • Mühlbauer RC, Bonjour JP, Fleisch H (1977) Tubular localization of adaptation to dietary phosphate in rats. Am J Physiol 233:F342–F348

    Google Scholar 

  • Mühlbauer RC, Bonjour JP, Fleisch H (1980) Chronic thyroparathyroidectomy and tubular handling of phosphate: Increased reabsorption in late but not in early proximal tubule. Pflügers Arch 388:185–189

    Google Scholar 

  • Mühlbauer RC, Bonjour JP, Fleisch H (1981a) Tubular handling of Pi: localization of effects of 1,25(OH)2D3 and dietary Pi in TPTX rats. Am J Physiol 241:F123–F128

    Google Scholar 

  • Mühlbauer RC, Bonjour JP, Fleisch H (1981b) Tubular handling of phosphate along the nephron of thyroparathyroidectomized rats injected with ethane-1-hydroxy-1, 1-diphosphonate. Clin Sci 60:171–177

    Google Scholar 

  • Mühlbauer RC, Bonjour JP, Fleisch H (1982a) Abnormal tubular adaptation to dietary Pi restriction in X-linked hypophosphatemic mice. Am J Physiol 242:F353–F359

    Google Scholar 

  • Mühlbauer RC, Bonjour JP, Fleisch H (1982b) Decrease in the tubular reabsorption of calcium with evidence for compensatory hyperparathyroidism in X-linked hypophosphatemia in mice. Clin Sci 62:503–508

    Google Scholar 

  • Murer H, Burckhardt G (1983) Membrane transport of anions across epithelia of mammalian small intestine and kidney proximal tubule. Rev Physiol Biochem Pharmacol 96:1–53

    Google Scholar 

  • Ney RL, Kelly G, Bartter FC (1968) Actions of vitamin D independent of the parathyroid glands. Endocrinology 82:760–766

    Google Scholar 

  • Nordin BEC (1976) Calcium, phosphate and magnesium metabolism. Clinical Physiology and diagnostic procedures. Churchill Livingstone, Edinburgh London New York

    Google Scholar 

  • Nseir NI, Szramowski J, Puschett JB (1978) Mechanism of the renal tubular effects of 25-hydroxy and 1,25-dihydroxy vitamin D3 in the absence of parathyroid hormone. Miner Electrolyte Metab 1:48–56

    Google Scholar 

  • Nyc JF, Kadner RJ, Crocken BJ (1966) A repressible alkaline phosphatase in Neurospora crassa. J Biol Chem 241:1468–1472

    Google Scholar 

  • Oberleithner H, Greger R, Lang F (1978) Role of calcium in the decline of phosphate reabsorption during phosphate loading in acutely thyroparathyroidectomized rats. Pflügers Arch 374:249–254

    Google Scholar 

  • Oberleithner H, Lang F, Greger R, Sporer H (1980) Additivity of the phosphaturic action of parathyrin and calcitonin in the rat kidney. In: Massry SG, Ritz E, Jahn H (eds) Phosphate and minerals in health and disease. Proc 4th Int workshop on phosphate and other minerals, Strasbourg 1979. Plenum Press, New York (Advances in experimental medicine and biology, vol 128, pp 129–134)

    Google Scholar 

  • Pabico RC, McKenna BA, Freeman RB (1975) Renal function before and after unilateral nephrectomy in renal donors. Kidney Int 8:166–175

    Google Scholar 

  • Pappenheimer AM (1936) The effect of experimental reduction of kidney substance upon the parathyroid glands and skeletal tissue. J Exp Med 64:965–980

    Google Scholar 

  • Pappenheimer AM, Wilens SL (1935) Enlargement of the parathyroid glands in renal disease. Am J Pathol 11:73–91

    Google Scholar 

  • Parfitt AM, Frame B (1976) Phosphate loading and depletion in vitamin D treated hypoparathyroidism. Implications for different physiological models of phosphate reabsorption. In: Avioli L, Bordier P, Fleisch H, Massry S, Slatopolsky E (eds) Phosphate metabolism, kidney and bone. Armour-Montagu, Paris, pp 179–197

    Google Scholar 

  • Pastoriza-Muñoz E, Colindres RE, Lassiter WE, Lechêne C (1978) Effect of parathyroid hormone on phosphate reabsorption in rat distal convolution. Am J Physiol 235:321–330

    Google Scholar 

  • Pastoriza-Muñoz E, Mishler DR, Lechène C (1983) Effect of the deprivation on phosphate reabsorption in rat nephron: role of PTH. Am J Physiol 244:F140–F149

    Google Scholar 

  • Pechet MM, Babadilla E, Caroll EL, Hesser RH (1967) Regulation of bone resorption and formation. Influences of thyrocalcitonin, parathyroid hormone, neutral phosphate and vitamin D. Am J Med 43:696–710

    Google Scholar 

  • Peraino RA, Suki WN (1980a) Influence of calcium on renal handling of phosphate. In: Massry SG, Fleisch H (eds) Renal handling of phosphate. Plenum, New York, pp 287–306

    Google Scholar 

  • Peraino RA, Suki WN (1980b) Phosphate transport by isolated rabbit cortical collecting tubule. Am J Physiol 238:F358–F362

    Google Scholar 

  • Peraino RA, Ghafary E, Rouse D, Stinebaugh BJ, Suki WN (1978) Effect of 25-hydroxycholecalciferol on renal handling of sodium, calcium, and phosphate during bicarbonate infusion. Miner Electrolyte Metab 1:321–329

    Google Scholar 

  • Petitclerc RA, Suki WN (1981) Renal transport of phosphate: role of alkaline phosphatase. Can J Physiol Pharmacol 59:311–323

    Google Scholar 

  • Pitts RF (1968) Physiology of the kidney and body fluids, 2nd edn. Year Book Medical, Chicago

    Google Scholar 

  • Plante RFGE, Petitclerc C, Nawar T, Erian R (1979) Increased phosphaturia during inhibition of renal alkaline phosphatase. Miner Electrolyte Metab 2:258

    Google Scholar 

  • Popovtzer MM (1978) Interactions between PTH, vitamin D metabolites and other factors in tubular reabsorption of phosphate. Adv Exp Med Biol 103:11–21

    Google Scholar 

  • Popovtzer MM, Robinette JB (1975) Effect of 25 (OH) vitamin D3 on urinary excretion of cyclic adenosine monophosphate. Am J Physiol 229:907–910

    Google Scholar 

  • Popovtzer MM, Wald H (1981) Evidence for interference of 25(OH) vitamin D3 with phosphaturic action of glucagon. Am J Physiol 240:F269–F275

    Google Scholar 

  • Popovtzer MM, Massry SG, Makoff DL, Maxwell MH, Kleeman CR (1969) Renal handling of phosphate in patients with chronic renal failure. The role of variations in serum phosphorus and parathyroid activity. Isr J Med Sci 5:1018–1023

    Google Scholar 

  • Popovtzer MM, Pinggera WF, Hutt MP, Robinette J, Halgrimson CG, Starzl TE (1972) Serum parathyroid hormone levels and renal handling of phosphorus in patients with chronic renal disease. J Clin Endocrinol Metab 35:213

    Google Scholar 

  • Popovtzer MM, Robinette JB, DeLuca HF, Holick MF (1974) The acute effect of 25-hydroxycholecalciferol on renal handling of phosphorus. Evidence for a parathyroid hormone-dependent mechanism. J Clin Invest 53:913–921

    Google Scholar 

  • Popovtzer MM, Blum MS, Flus RS (1977) Evidence for interference of 25(OH)vitamin D3 with phosphaturic action of calcitonin. Am J Physiol 232:E515–E521

    Google Scholar 

  • Pors-Nielsen S, Buchanan-Lee B, Matthews EW, Moseley JM, Williams CC (1971) Acute effects of synthetic porcine calcitonin on the renal excretion of magnesium, inorganic phosphate, sodium and potassium. J Endocrinol 51:455–464

    Google Scholar 

  • Poujeol P (1979) Contribution à l'étude de la régulation du comportement renal des ions phosphates, calcium et magnesium, chez le rat. Ph D dissertation, Univ Pierre et Marie Curie, Paris

    Google Scholar 

  • Poujeol P, Corman B, Touvay C, De Rouffignac C (1977) Phosphate reabsorption in rat nephron terminal segments: Intrarenal hetereogeneity and strain differences. Pflügers Arch 371:39–44

    Google Scholar 

  • Poujeol P, Jamison RL, De Rouffignac C (1980a) Phosphate reabsorption in juxtamedullary nephron terminal segments. Pflügers Arch 387:27–31

    Google Scholar 

  • Poujeol P, Touvay C, Roinel N, De Rouffignac C (1980b) Stimulation of renal magnesium reabsorption by calcitonin in the rat. Am J Physiol 239:F524–F532

    Google Scholar 

  • Puschett JB (1978) Renal tubular effects of parathyroid hormone: an update. Clin Orthop 135:249–259

    Google Scholar 

  • Puschett JB (1982) Are all of the renal tubular actions of parathyroid hormone mediated by the adenylate cyclase system? Miner Electrolyte Metab 7:281–284

    Google Scholar 

  • Puschett JB, Kuhrman MS (1978) Renal tubular effects of 1,25-dihydroxyvitamin D3: interactions with vasopressin and parathyroid hormone in the vitamin D-depleted rat. J Lab Clin Med 92:895–903

    Google Scholar 

  • Puschett JB, Fernandez PC, Boyle IT, Gray RW, Omdahl JL, DeLuca HF (1972a) The acute renal tubular effects of 1,25-dihydroxycholecalciferol. Proc Soc Exp Biol Med 141:379–384

    Google Scholar 

  • Puschett JB, Moranz J, Kurnick WS (1972b) Evidence for a direct action of cholecalciferol and 25-hydroxycholecalciferol on the renal transport of phosphate, sodium, and calcium. J Clin Invest 51:373–385

    Google Scholar 

  • Puschett JB, Winaver J, Chen TC, Fragola J, Sylk DB, Robertson JS (1981) Study of the renal tubular sites and mechanisms of action of parathyroid hormone. Miner Electrolyte Metab 6:190–209

    Google Scholar 

  • Rasmussen H (1970) Cell communication, calcium ion and cyclic adenosine monophosphate. Science 170:404–411

    Google Scholar 

  • Rasmussen H, Anast C, Arnaud C (1967) Thyrocalcitonin, EGTA and urinary electrolyte excretion. J Clin Invest 46:746–752

    Google Scholar 

  • Ritz E, Kreusser W, Bommer J (1980) Effects of hormones other than parathyroid hormones on renal handling of phosphate. In: Massry SG, Fleisch H (eds) Renal handling of phosphate. Plenum Medical, New York, pp 137–196

    Google Scholar 

  • Rizzoli R, Fleisch H, Bonjour JP (1977a) Effect of thyroparathyroidectomy on calcium metabolism in rats: role of 1,25-dihydroxy-vitamin D3. Am J Physiol 233:E160–E164

    Google Scholar 

  • Rizzoli R, Fleisch H, Bonjour JP (1977b) Role of 1,25-dihydroxyvitamin D3 on intestinal phosphate absorption in rats with a normal vitamin D supply. J Clin Invest 60:639–647

    Google Scholar 

  • Robinson CJ, Martin TJ, MacIntyre I (1966) Phosphaturic effect of thyrocalcitonin. Lancet II:83–84

    Google Scholar 

  • Robinson CJ, Martin TJ, Matthews EW, MacIntyre I (1967) Mode of action of thyrocalcitonin. J Endocrinol 39:71–79

    Google Scholar 

  • Rocha AS, Magaldi JB, Kokko JP (1977) Calcium and phosphate transport in isolated segments of rabbit's Henle's loop. J Clin Invest 59:975–984

    Google Scholar 

  • Rosen JF, Fleischmann AR, Finberg L, Eisman J, DeLuca HF (1977) 1,25-dihydroxy-cholecalciferol: its use in the ling term management of idiopathic hypoparathyroidism in children. J Clin Endocrinol 45:457–468

    Google Scholar 

  • Rosenbaum RW, Hruska KA, Korkor A, Anderson C, Slatopolsky E (1981) Decreased phosphate reabsorption after renal transplantation: Evidence for a mechanism independent of calcium and parathyroid hormone. Kidney Int 19:568–578

    Google Scholar 

  • Rosenberg EM, Lee SW, Chase LR, Avioli LV (1980) Phosphate accumulation by the isolated renal tubule and the effects of parathyroid hormone and cyclic monophosphate. J Lab Clin Med 96:24–35

    Google Scholar 

  • Russell RGG, Smith R, Preston C, Walton RJ, Woods CG, Henderson RG, Norman AW (1975) The effect of 1,25-dihydroxycholecalciferol on renal tubular reabsorption of phosphate, intestinal absorption of calcium and bone histology in hypophosphataemic renal tubular rickets. Clin Sci Mol Med 48:177–186

    Google Scholar 

  • Schneider EG, McLane LA (1977) Evidence for a peritubular-to-luminal flux of phosphate in the dog kidney. Am J Physiol 232:F159–F166

    Google Scholar 

  • Shah SV, Kempson SA, Northrup TE, Dousa TP (1979) Renal adaptation to a low phosphate diet in rats, blockade by actinomycin D. J Clin Invest 64:955–966

    Google Scholar 

  • Shareghi GR, Agus ZS (1982) Phosphate transport in the light segment of the rabbit cortical collecting tubule. Am J Physiol 242:F379–F384

    Google Scholar 

  • Slatopolsky E, Gradowska L, Kashemsant C, Keltner R, Manley C, Bricker NS (1966) The control of phosphate excretion in uremia. J Clin Invest 45:672–677

    Google Scholar 

  • Slatopolsky E, Robson AM, Elkan J, Bricker NS (1968) Control of phosphate excretion in uremic man. J Clin Invest 47:1865–1874

    Google Scholar 

  • Slatopolsky E, Caglar S, Pennell JP, Taggart DD, Canterbury JM, Reiss E, Bricker NS (1971) On the pathogenesis of hyperparathyroidism in chronic experimental renal insufficiency in the dog. J Clin Invest 50:492–499

    Google Scholar 

  • Slatopolsky E, Rutherford WE, Hruska K, Martin K, Klahr S (1978) How important is phosphate in the pathogenesis of renal osteodystrophy? Arch Intern Med 138:848–852

    Google Scholar 

  • Smith HW (1939) The excretion of phosphate in the dog-fish, Squalus acanthia. J Cell Comp Physiol 14:95–102

    Google Scholar 

  • Sorensen OH, Hindberg I (1972) The acute and prolonged effect of porcine calcitonin on urine electrolyte excretion in intact and parathyroidectomized rats. Acta Endocrinol 70:295–307

    Google Scholar 

  • Steele TH (1976) Renal resistance to parathyroid hormone during phosphorus deprivation. J Clin Invest 58:1461–1464

    Google Scholar 

  • Steele TH (1982) Interactions of starvation and selective phosphorus depletion on renal phosphate reabsorption. Renal Physiol 5:44–52

    Google Scholar 

  • Steele TH, DeLuca HF (1976) Influence of dietary phosphorus on renal phosphate reabsorption in the parathyroidectomized rats. J Clin Invest 57:867–874

    Google Scholar 

  • Steele TH, Engle JE, Tanaka Y, Lorenc RS, Dudgeon KL, DeLuca HF (1975) Phosphatemic action of 1,25-dihydroxyvitamin D3. Am J Physiol 229:489–495

    Google Scholar 

  • Stoll R, Kinne R, Murer H, Fleisch H, Bonjour JP (1979a) Phosphate transport by rat renal brush border membrane vesicles: Influence of dietary phosphate, thyroparathyroidectomy, and 1,25-dihydroxyvitamin D3. Pflügers Arch 380:47–52

    Google Scholar 

  • Stoll R, Kinne R, Murer H (1979b) Effect of dietary phosphate intake on phosphate transport by isolated rat renal brush-border vesicles. Biochem J 180:465–470

    Google Scholar 

  • Stoll R, Murer H, Fleisch H, Bonjour JP (1980) Effect of diphosphonate treatment on phosphate transport by renal brush border vesicles. Am J Physiol 239:F13–F16

    Google Scholar 

  • Storelli C, Murer H (1980) On the correlation between alkaline phosphatase and phosphate transport in rat renal brush border membrane vesicles. Pflügers Arch 384:149–153

    Google Scholar 

  • Strickler JC, Thompson D, Klose R, Giebisch G, Gluck JN, Vaughan JB (1964) Micropuncture study of inorganic phosphate excretion in the rat. J Clin Invest 43:1596–1607

    Google Scholar 

  • Sutton RAL, Quamme GA, Dirks JH (1978) Transport of calcium, magnesium and inorganic phosphate in the kidney. In: Giebisch G, Tosteson DC, Ussing HH (eds) Membrane transport in biology, transport organs. Springer, Berlin Heidelberg New York, pp 357–412

    Google Scholar 

  • Swenson RB, Wesinger JR, Ruggeri JL, Reaven JM (1975) Evidence that parathyroid hormone is not required for phosphate homeostasis in renal failure. Metabolism 24:199–204

    Google Scholar 

  • Talmage RV, Anderson JJB, Cooper CW (1972) Calcitonins on the disappearance of radiocalcium and radiophosphorus from plasma. Endocrinology 90:1185

    Google Scholar 

  • Talmage RV, Whitehurst LA, Anderson JJB (1973) Effect of calcitonin and calcium infusion on plasma phosphate. Endocrinology 92:792

    Google Scholar 

  • Taugner R, Brunoff M von, Brown W (1953) Gibt es eine tubuläre Phosphatsekretion über die Ausscheidung von anorganischem und organischem Phosphat bei der Katze? Pflügers Arch 258:133–148

    Google Scholar 

  • Tenenhouse HS, Chu YL (1982) Hydrolysis of nicotinamide-adenine dinucleotide by purified renal brush-border membranes. Biochem J 204:635–638

    Google Scholar 

  • Tenenhouse HS, Scriver CR (1978) The defect in transcellular transport of phosphate in the nephron is located in brush border membranes in X-linked hypophosphatemia. Can J Biochem 56:640–646

    Google Scholar 

  • Tenenhouse HS, Scriver CR (1979a) Renal adaptation to phosphate deprivation in the Hyp mouse with X-linked hypophosphatemia. Can J Biochem 57:938–944

    Google Scholar 

  • Tenenhouse HS, Scriver CR (1979b) Renal brush border membrane adaptation to phosphorus deprivation in the Hyp/Y mouse. Nature 281:225–227

    Google Scholar 

  • Tenenhouse HS, Scriver CR, Vizel EJ (1980) Alkaline phosphatase activity does not mediate phosphate transport in the renal-cortical brush-border membrane. Biochem J 190:473–476

    Google Scholar 

  • Torriani A (1960) Influence of inorganic phosphate in the formation of phosphatases by Escherichia coli. Biochim Biophys Acta 38:460–469

    Google Scholar 

  • Trechsel U, Eisman JA, Fischer JA, Bonjour JP, Fleisch H (1980) Calcium-dependent, parathyroid hormone-independent regulation of 1,25-dihydroxyvitamin D. Am J Physiol 239:E119–E124

    Google Scholar 

  • Troehler U, Bonjour JP, Fleisch H (1976) Inorganic phosphate homeostasis. Renal adaptation to the dietary intake in intact and thyroparathyroidectomized rats. J Clin Invest 57:264–273

    Google Scholar 

  • Troehler U, Bonjour JP, Fleisch H (1981) Plasma level and renal handling of Pi: effect of overnight fasting with and without Pi supply. Am J Physiol 241:F509–F516

    Google Scholar 

  • Troehler U, Bonjour JP, Fleisch H (1983) Extrarenal handling of phosphate: effect of thyroparathyroidectomy, 1,25-dihydroxycholecalciferol, and dietary calcium. Min Electrolyte Metab 9:181

    Google Scholar 

  • Tweedy WR, Campbell WW (1944) The effect of parathyroid extract upon the distribution, retention and excretion of labelled phosphorus. J Biol Chem 154:339

    Google Scholar 

  • Ullrich KJ, Rumrich G, Kloss S (1977) Phosphate transport in the proximal convolution of the rat kidney. I. Tubular heterogeneity, effect of parathyroid hormone in acute and parathyroidectomized animals, and effect of phosphate diet. Pflügers Arch 372:269–274

    Google Scholar 

  • Ullrich KJ, Rumrich G, Kloss S (1978) Phosphate transport in the proximal convolution of the rat kidney. II. Effect of extracellular Ca2+ and application of the Ca2+ ionophore A 23187 in chronic PTX animals. Pflügers Arch 377:33–42

    Google Scholar 

  • Wald H, Popovtzer MM (1980) Antagonistic effects of 25 (OH) vitamin D3 and peptide hormones on the activation of adenylate cyclase cyclic AMP system in renal tissue in vitro. Adv Exp Med Biol 128:625–633

    Google Scholar 

  • Walker AM, Hudson CC (1937) The role of the tubule in the excretion of inorganic phosphate by the amphibian kidney. Am J Physiol 118:167–173

    Google Scholar 

  • Ward HN, Pabico RC, McKenna BA, Freeman RB (1977) The renal handling of phosphate by renal transplant patients: correlation with serum parathyroid hormone (SPTH), cyclic 3′, 5′-adenosine monophosphate (cAMP) urinary excretion, and allograft function. Adv Exp Med Biol 81:173–181

    Google Scholar 

  • Webster GD, Mann JB, Hills AG (1967) The effect of phosphate infusions upon renal phosphate clearance in man: evidence for tubular phosphate secretion. Metabolism 16:797–814

    Google Scholar 

  • Weinmann EJ, Suki WN (1978) Evidence for phosphate secretion in the rat kidney. Miner Electrolyte Metab 1:92–98

    Google Scholar 

  • Wen SF (1974) Micropuncture studies of phosphate transport in the proximal tubule of the dog. The relationship to sodium reabsorption. J Clin Invest 53:143–153

    Google Scholar 

  • Wen SF, Boynar JW Jr, Stoll RW (1978) Effect of phosphate deprivation on renal phosphate transport in the dog. Am J Physiol 234:F199–F206

    Google Scholar 

  • Wen SF, Stoll RW (1981) Renal phosphate adaptation in uraemic dogs with a remnant kidney. Clin Sci 60:273–281

    Google Scholar 

  • Wideman RF Jr, Braun EJ (1981) Stimulation of avian renal phosphate secretion by parathyroid hormone. Am J Physiol 241:F263–F272

    Google Scholar 

  • Wideman RF Jr, Clark NB, Braun EJ (1980) Effects of phosphate loading and parathyroid hormone on starling renal phosphate excretion. Am J Physiol 239:F233–F243

    Google Scholar 

  • Winaver J, Puschett JB (1978) Structural determinants of the renal tubular activity of vitamin D3 derivatives: Studies with 1a hydroxy, 24R, 25-dihydroxy and 1a, 24,25 trihydroxyvitamin D3. Proc Soc Exp Biol Med 159:204–209

    Google Scholar 

  • Wolbach RA (1970) Phlorizin and renal phosphate secretion in the spiny dogfish, Squalus acanthia. Am J Physiol 219:886–888

    Google Scholar 

  • Wong NLM, Quamme GA, O'Callaghan TJ, Sutton RAL, Dirks JH (1980) Renal tubular transport in phosphate depletion: a micropuncture study. Can J Physiol Pharmacol 50:1063–1071

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Division of Pathophysiology, Department of Medicine, University of Geneva, Geneva, Switzerland

    Joseph Caverzasio

Authors
  1. Jean-Phlippe Bonjour
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Joseph Caverzasio
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

Copyright information

© 1984 Springer-Verlag

About this chapter

Cite this chapter

Bonjour, JP., Caverzasio, J. (1984). Phosphate transport in the kidney. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 100. Reviews of Physiology, Biochemistry and Pharmacology, vol 100. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3540133275_4

Download citation

  • DOI: https://doi.org/10.1007/3540133275_4

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-13327-8

  • Online ISBN: 978-3-540-38851-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation