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Process development and economic aspects in enzyme engineering. Acylase L-methionine system

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Advances in Biomedical Engineering

Part of the book series: Advances in Biochemical Engineering ((ABE,volume 12))

Abstract

An integral study of chemical reaction engineering and process development including economic aspects was carried out using the optical resolution of aminoacids by means of native and carrier-fixed acylase as example. Continuous operation is not only possible with carrier-fixed enzymes but also with native enzymes using ultrafiltration devices for catalyst retention. It could experimentally be proved on a 1 kg L-methionine/d-scale that the use of soluble acylase in membrane-reactors is economically superior to the carrier-fixed type in the tube-reactors. In all cases where immobilization of enzymes cannot be achieved with high activity yield or remarkable increase in stability, the homogeneous catalysis with soluble enzymes in continuously operating membrane-reactors might be a very promising alternative. — These studies were performed at the “Institut für Technische Che-mie der Technischen Universität Hannover”, West-Germany.

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Authors and Affiliations

  1. Institut für Biotechnologie II, Kernforschungsanlage Jülich, D-5170, Jülich, West Germany

    Christian Wandrey

  2. Institut de Génie Chimique III, Ecole Poly technique Fédérate de Lausanne Ecublens, CH-1015, Lausanne, Switzerland

    Erwin Flaschel

Authors
  1. Christian Wandrey
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  2. Erwin Flaschel
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© 1979 Springer-Verlag

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Wandrey, C., Flaschel, E. (1979). Process development and economic aspects in enzyme engineering. Acylase L-methionine system. In: Advances in Biomedical Engineering. Advances in Biochemical Engineering, vol 12. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3540092625_9

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  • DOI: https://doi.org/10.1007/3540092625_9

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-09262-9

  • Online ISBN: 978-3-540-35266-2

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