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The physiologic determinants of glomerular ultrafiltration

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Abbreviations

AII :

Angiotensin II

ADH:

Antidiuretic hormone

Ach:

Acetycholine

\(\overline {AP}\) :

Mean arterial pressure, mm Hg

AVP:

Arginine vasopressin

BK:

Bradykinin

C:

Protein concentration, g/100 ml

FF:

Whole kidney filtration fraction

G:

Gentamicin

GFR:

Glomerular filtration rate, ml/min.

k:

Effective hydraulic permeability, nl/ (sec·mm Hg·cm2)

Kf :

Ultrafiltration coefficient, nl/ (sec·mm Hg)

NE:

Norepinephrine.

NSN:

Nephrotoxic serum nephritis

P:

Hydraulic pressure, mm Hg

PAN:

Puromycin aminonucleoside

PGE1 :

Prostaglandin E1

PUF :

Net ultrafiltration pressure, mm Hg

ΔP:

Transmembrane hydraulic pressure difference, PGC - PT, mm Hg

QA :

Initial glomerular capillary plasma flow rate, nl/min.

∏:

Colloid osmotic pressure, mm Hg

Δ∏:

Transmembrane osmotic pressure difference, ∏GC - ∏T, mm Hg

R:

Resistance to blood flow, dynes·s·cm−5·1010

RBF/RPF:

Renal blood/plasma flow rate, ml/min.

S:

Surface area available for ultrafiltration, cm2

SNFF:

Single nephron filtration fraction

SNGFR:

Single nephron glomerular filtration rate, nl/min.

--:

Mean Value

A:

Afferent arteriole

E:

Efferent arteriole

GC:

Glomerular capillary

T:

Bowman's space or beginning of proximal tubule

References

  • Allison, M. E. M., Lipham, E. M., Lassiter, W. E., Gottschalk, C. W.: The acutely reduced kidney. Kidney Int. 3, 354–363 (1973)

    Google Scholar 

  • Allison, M. E. M., Wilson, C. B., Gottschalk, C. W.: Pathophysiology of experimental glomerulonephirtis in rats. J. clin. Invest. 53, 1402–1423 (1974)

    Google Scholar 

  • Ames, E., Steven, K., Skadhauge, E.: Effects of arginine vasotocin on renal excretion of Na+, K+, Cl and urea in the hydrated chicken. Amer. J. Physiol. 221, 1223–1228 (1971)

    Google Scholar 

  • Andreucci, V. E., Dal Canton, A., Corradi, A., Stanziale, R., Migone, L.: Role of the efferent arteriole in glomerular hemodynamics of superficial nephrons. Kidney Int. 9, 475–480 (1976)

    Google Scholar 

  • Aperia, A., Broberger, O., Herin, P.: Maturational changes in glomerular perfusion rate and glomerular filtration rate in lambs. Pediat. Res. 8, 758–765 (1974)

    Google Scholar 

  • Aperia, A., Herin, P.: Development of glomerular perfusion rate and nephron filtration rate in rats 17–60 days old. Amer. J. Physiol. 228, 1319–1325 (1975)

    Google Scholar 

  • Arendshorst, W. J., Gottschalk, C. W.: Apparent filtration pressure disequilibrium and filtration coefficient in the rat kidney. Amer. Soc. Nephrol. 7, 4 (1974). Abstract

    Google Scholar 

  • Arriieta de Muchnik, E. E., Lipham, E. M., Gottschalk, C. W.: Form and function in normal and hypertrophied nephrons. In: Compensatory Renal Hypertrophy. Nowinski, W. W., Goss, R. J. (eds.) New York: Academic Press 1969, pp. 29–44

    Google Scholar 

  • Aukland, K.: Heat clearance in the renal medulla. Acta physiol. scand. Suppl. 277, 18 (1966) Abstract

    Google Scholar 

  • Baer, P. G., Navar, L. G., Guyton, A. C.: Renal autoregulation, filtration rate and electrolyte excretion during vasodilation. Amer. J. Physiol. 219, 619–625 (1970)

    Google Scholar 

  • Bank, N., Aynedjian, H. S.: Individual nephron function in experimental bilateral pyelonephritis. I. Glomerular filtration rate and proximal tubular sodium, potassium and water reabsorption. J. Lab. clin. Med. 68, 713–727 (1966)

    Google Scholar 

  • Baylis, C., Bohrer, M., Troy, J. L., Robertson, C. R., Brenner, B. M.: Mechanism of the puromycin-induced defects in transglomerular passage of water and macromolecules. Amer. Soc. Nephrol. 9, 68 (1976a) Abstract

    Google Scholar 

  • Baylis, C., Rennke, H. R., Brenner, B. M.: Mechanism of gentamicin-induced defect in glomerular filtration. Clin. Res. 25, 426A (1977) Abstract

    Google Scholar 

  • Baylis, C., Deen, W. M., Myers, B. D., Brenner, B. M.: Effect of some vasodilator drugs on transcapillary fluid exchange in the renal cortex. Amer. J. Physiol. 230, 1148–1158 (1976b)

    Google Scholar 

  • Baylis, C., Ichikawa, I., Willis, W. T., Wilson, C. B., Brenner, B. M.: Dynamics of glomerular ultrafiltration IX. Effects of plasma protein concentration. Amer. J. Physiol. Renal, Fluid, Electrol. 1, F58–F71 (1977)

    Google Scholar 

  • Berne, R. M.: Hemodynamics and sodium excretion of denervated kidney in anesthetized and unanesthetized dog. Amer. J. Physiol. 171, 148–158 (1952)

    Google Scholar 

  • Blantz, R. C.: Effect of mannitol on glomerular ultrafiltration in the hydropenic rat. J. clin. Invest. 54, 1135–1143 (1974)

    Google Scholar 

  • Blantz, R. C.: The mechanism of acute renal failure after uranyl nitrate. J. clin. Invest. 55, 621–635 (1975)

    Google Scholar 

  • Blantz, R. C., Israelit, A. H., Rector, Jr., F. C., Seldin, D. W.: Relation of distal tubular NaCl delivery and glomerular hydrostatic pressure. Kidney Int. 2, 22–32 (1972)

    Google Scholar 

  • Blantz, R. C., Konnen, K. S., Tucker, B. J.: Glomerular filtration response to elevated ureteral pressure in both the hydropenic and the plasma-expanded rat. Cir-culat. Res. 37, 819–829 (1975)

    Google Scholar 

  • Blantz, R. C., Konnen, K. S., Tucker, B. J.: Angiotensin II effects upon the glomerular microcirculation and ultrafiltration coefficient of the rat. J. clin. Invest. 57, 419–434 (1976)

    Google Scholar 

  • Blantz, R. C., Rector, Jr., F.C., Seldin, D. W.: Effect of hyperoncotic albumin expansion upon glomerular ultrafiltration in the rat. Kidney Int. 6, 209–221 (1974)

    Google Scholar 

  • Blantz, R. C., Wilson, C. B.: Glomerular filtration following acute immunological glomerular injury. Amer. Soc. Nephrol. 8, 60 (1975). Abstract

    Google Scholar 

  • Bohrer, M. P., Troy, J. L., Deen, W. M., Robertson, C. R., Brenner, B. M.: Mechanism of angiotensin II-induced proteinuria. Clin. Res. 24, 394 (1976). Abstract

    Google Scholar 

  • Bonjour, J. P., Malvin, R. L.: Renal extraction of PAH, GFR, and UnaV in the rat during infusion of angiotensin. Amer. J. Physiol. 216, 554–558 (1974)

    Google Scholar 

  • Bowman, R. H., Maack, T.: Effect of albumin concentration and ADH on H2O and electrolyte transport in perfused rat kidney. Amer. J. Physiol. 226,426–430 (1974)

    Google Scholar 

  • Braun, E. J., Dantzler, W. H.: Effects of ADH on single nephron glomerular filtration rates in the avian kidney. Amer. J. Physiol. 226, 1–8 (1974)

    Google Scholar 

  • Brenner, B. M., Troy, J. L., Daugharty, T. M.: The dynamics of glomerular ultrafiltration in the rat. J. clin. Invest. 50, 1776–1780 (1971)

    Google Scholar 

  • Brenner, B. M., Troy, J. L., Daugharty, T. M., Deen, W. M., Robertson, C. R.: Dynamics of glomerular ultrafiltration in the rat. II. Plasma-flow dependence of GFR. Amer. J. Physiol. 223, 1184–1190 (1972a)

    Google Scholar 

  • Brenner, B. M., Ueki, I. F., Daugharty, T. M.: On estimating colloid osmotic pressure in pre-and postglomerular plasma in the rat. Kidney Int. 2, 51–53 (1972b)

    Google Scholar 

  • Brown, E., Landis. E. M.: Effect of local cooling on fluid movements, effective osmotic pressure and capillary permeability in the frog's mesentery. Amer. J. Physiol. 149, 302–315 (1947)

    Google Scholar 

  • Burgess, W. W., Harvey, A. M., Marshall, Jr. E. K.: The site of the antidiuretic action of pituitary extract. J. Pharmacol. exp. Ther. 49, 237–249 (1933)

    Google Scholar 

  • Carlson, E. L., Sparks, H. V.: Intrarenal distribution of blood flow during elevation of ureteral pressure in dogs. Circulat. Res. 26, 601–610 (1970)

    Google Scholar 

  • Chang, R. L. S., Deen, W. M., Robertson, C. R., Bennett, C. M., Glassock, R. J., Brenner, B. M.: Permselectivity of the glomerular capillary wall. Studies of experimental glomerulonephritis in the rat using neutral dextran. J. clin. Invest. 57, 1272–1286 (1976)

    Google Scholar 

  • Cox, J. W., Baehler, R. W., Sharma, H., O'Dorisio, T., Osgood, R. W., Stein, J. H., Ferris, T. F.: Studies on the mechanism of oliguria in a model of unilateral acute renal failure. J. clin. Invest. 53, 1546–1558 (1974)

    Google Scholar 

  • Dantzler, W. H.: Glomerular and tubular effects of arginine vasotocin in water snakes. (Natrix Sipedon). Amer. J. Physiol. 212, 83–91 (1967)

    Google Scholar 

  • Daugharty, T. M., Ueki, I. F., Mercer, P. F., Brenner, B. M.: Dynamics of glomerular ultrafiltration in the rat. V. Response to ischemic injury J. clin. Invest. 53, 105–116 (1974)

    Google Scholar 

  • Davis, B. B., Walter, M. J., Murdaugh, Jr. H. V.: Renal response to graded saline challenge. Amer. J. Physiol. 217, 1604–1607 (1969)

    Google Scholar 

  • Davis, J. M., Schnermann, J.: The effect of antidiuretic hormone on the distribution of nephron filtration rates in rats with hereditary diabetes insipidus. Pflüegers Arch. ges. Physiol. 330, 323–334 (1971)

    Google Scholar 

  • Deen, W. M., Maddox, D. A., Robertson, C. R., Brenner, B. M.: Dynamics of glomerular ultrafiltration in the rat. VII. Response to reduced renal mass. Amer. J. Physiol. 227, 556–562 (1974a)

    Google Scholar 

  • Deen, W. M., Robertson, C. R., Brenner, B. M.: A model of glomerular ultrafiltration in the rat. Amer. J. Physiol. 223, 1178–1183 (1972)

    Google Scholar 

  • Deen, W. M., Robertson, C. R., Brenner, B. M.: Brief Reviews. Transcapillary fluid exchange in the renal cortex. Circulat. Res. 33, 1–8 (1973a)

    Google Scholar 

  • Deen, W. M., Robertson, C. R., Brenner, B. M.: Glomerular ultrafiltration. Fed. Proc. 33, 14–20 (1974b)

    Google Scholar 

  • Deen, W. M., Troy, J. L., Robertson, C. R., Brenner, B. M.: Dynamics of glomerular ultrafiltration in the rat. IV. Determination of the ultrafiltration coefficient. J. clin. Invest. 52, 1500–1508 (1973b)

    Google Scholar 

  • Eisenbach, G. M., Liew, J. B. van, Boylan, J. W.: Effect of angiotensin on the filtration of protein in the rat kidney: a micropuncture study. Kidney Int. 8, 80–87 (1975)

    Google Scholar 

  • Forster, R. P., Maes, J. P.: Effect of experimental neurogenic hypertension on renal blood flow and glomerular filtration rates in intact denervated kidneys of unanesthetized rabbits with adrenal glands demedullated. Amer. J. Physiol. 150, 534–540 (1947)

    Google Scholar 

  • Gagnon, J. A., Keller, H. I., Kokotis, W., Schrier, R. W.: Analysis of role of renin-angiotensin system in autoregulation of glomerular filtration. Amer. J. Physiol. 219, 491–496 (1970)

    Google Scholar 

  • Gaizutis, M., Pesce, A. J., Lewy, J. E.: Determination of nanogram amounts of albumin by radioimmunossay. Microchem. J. 17, 327–337 (1972)

    Google Scholar 

  • Gertz, K. H., Mangos, J. A., Braun, G., Pagel, H. D.: Pressure in the glomerular capillaries of the rat kidney and its relation to arterial blood pressure. Pflüegers Arch. ges. Physiol. 288, 369–374 (1966)

    Google Scholar 

  • Gomez, D. M.: Evaluation of renal resistances, with special reference to changes in essential hypertension. J. clin. Invest. 30, 1143–1155 (1951)

    Google Scholar 

  • Gore, R. W., Bohlen, H. G.: Pressure regulation in the microcirculation. Fed. Proc. 34, 2031–2037 (1975)

    Google Scholar 

  • Gottschalk, C. W., Mylle, M.: Micropuncture study of pressures in proximal tubules and peritubular capillaries of the rat kidney and their relation to ureteral and renal venous pressures. Amer. J. Physiol. 185, 430–439 (1956)

    Google Scholar 

  • Gottschalk, C. W.: Function of the chronically diseased kidney. The adaptive nephron. Circulat. Res. 23 and 24, Suppl. II, II–1–II–13 (1971)

    Google Scholar 

  • Grängsjö, G., Wolgast, M.: The pressure-flow relationship in renal cortical and medullary circulation. Acta physiol. scand. 85, 228–236 (1972)

    Google Scholar 

  • Gruskin, A. B., Edelmann, C. M., Ynan, S.: Maturational changes in renal blood flow in piglets. Pediat. Res. 4, 7–13 (1970)

    Google Scholar 

  • Guignard, J. P., Torrado, A., Da Cunha, A., Gautier, E.: Glomerular filtration rate in the first three weeks of life. J. Pediat. 87, 268–272 (1975)

    Google Scholar 

  • Handler, J. S., Orloff, J.: The mechanism of action of antidiuretic hormone. In: Handbook of Physiology. Section 8: Renal Physiology. Orloff, J., Berliner, R. W. (eds.). Washington D. C.: Amer. Physiol. Soc. 1973, pp. 791–814

    Google Scholar 

  • Hayslett, J. P., Kashgarian, M., Epstein, F. H.: Functional correlates of compensatory renal hypertrophy. J. clin. Invest. 47, 774–782 (1968)

    Google Scholar 

  • Hayslett, J. P., Kashgarian, M., Epstein, F. H.: Mechanism of change in the excretion of sodium per nephron when renal mass is reduced. J. clin. Invest. 48, 1002–1006 (1969)

    Google Scholar 

  • Horster, M., Kemler, B. J., Valtin, H.: Intracortical distribution of number and volume of glomeruli during postnatal maturation in the dog. J. clin. Invest. 50, 796–800 (1971)

    Google Scholar 

  • Horster, M., Valtin, H.: Postnatal development of renal function: micropuncture and clearance studies in the dog. J. clin. Invest. 50, 779–795 (1971)

    Google Scholar 

  • Howards, S. H., Wright, F. S.: Obstructive injury. In: The Kidney. Brenner, B. M., Rector, Jr. F. C., (eds.). Philadelphia: W. B. Saunders and Co. 1976, pp. 1297–1325

    Google Scholar 

  • Ichikawa, I., Brenner, B. M.: Evidence for glomerular actions of ADH and dibutyryl cyclic AMP in the rat. Amer. J. Physiol: Renal, Fluid, Electrol; 2, F102–F117, 1977

    Google Scholar 

  • Imbert, M., Chabardés, D., Morel, F.: Hormone sensitive adenylate cyclase in isolated rabbit glomeruli. Molec. cell. Endocr. 1, 295–304 (1974)

    Google Scholar 

  • Israelit, A. H., Seldin, D. W.: Feedback regulation of glomerular capillary pressure (PG) in plasma expanded rat. Clin. Res. 22, 41 (1974). Abstract.

    Google Scholar 

  • Jaenike, J. R.: Micropuncture study of methemoglobin-induced acute renal failure in the rat. J. Lab. clin. Med. 73, 459–468 (1969)

    Google Scholar 

  • Jaenike, J. R.: The renal response to ureteral obstruction: a model for the study of factors which influence glomerular filtration pressure. J. Lab. clin. Med. 76, 373–382 (1970)

    Google Scholar 

  • Jamison, R. L.: Urinary concentration and dilution. The role of antidiuretic hormone and the role of urea. In: The Kidney. Brenner, B. M., Rector, Jr., F. C. (eds.). Philadelphia: W. B. Saunders and Co. 1976, pp. 391–441

    Google Scholar 

  • Johnson, P. C., Hanson, K. M.: Effect of arterial pressure on arterial and venous resistance of intestine. J. appl. Physiol. 17, 503–508 (1962)

    Google Scholar 

  • Johnston, H. H., Herzog, J. P., Lauler, D. P.: Effect of prostaglandin E1 on renal hemodynamics, sodium and water excretion. Amer. J. Physiol. 213, 939–946 (1967)

    Google Scholar 

  • Källskog, Ö., Lindbom, L. O., Ulfendahl, H. R., Wolgast, M.: Kinetics of the glomerular ultrafiltration in the rat kidney. An experimental study. Acta physiol. scand. 95, 293–300 (1975a)

    Google Scholar 

  • Källskog, Ö., Lindbom, L. O., Ulfendahl, H. R., Wolgast, M.: The pressure-flow relationship of different nephron populations in the rat. Acta physiol. scand. 94, 289–300 (1975b)

    Google Scholar 

  • Kahn, T., Stein, R. M.: Gentamicin and renal failure. Lancet (1972) I, 498

    Google Scholar 

  • Kamm, D. E., Levinsky, N. G.: The mechanism of denervation natriuresis. J. clin. Invest. 44, 93–102 (1965)

    Google Scholar 

  • Kaufman, J. M., Di Meola, H. J., Siegel, N. J., Lytton, B., Kashgarian, M., Hayslett, J. P.: Compensatory adaptation of structure and function following progressive renal ablation. Kidney Int. 6, 10–17 (1974)

    Google Scholar 

  • Kirkman, H., Stowell, R. E.: Renal filtration surface in the albino rat. Anat. Rec. 82, 373–391 (1942)

    Google Scholar 

  • Klahr, S., Alleyne, G. A. O.: Effects of chronic protein-calorie malnutrition on the kidney. Editorial Review. Kidney Int. 3, 129–141 (1973)

    Google Scholar 

  • Kleinman, L. I., Reuter, J. H.: Renal response of the new-born dog to a saline load: the use of intrarenal blood flow distribution. J. Physiol. (Lond.) 239, 225–236 (1974)

    Google Scholar 

  • Knox, F. G., Cuche, J. L., Ott, C. E., Diaz-Buxo, J. A., Marchand, G.: Regulation of glomerular filtration and proximal tubule reabsorption. Circulat Res. 36–37, Suppl. 1, 1–107–1–118 (1975)

    Google Scholar 

  • Kosek, J. C., Mazze, R. I., Cousins, M. J.: Nephrotoxicity of gentamicin. Lab. Invest. 30, 48–57 (1974)

    Google Scholar 

  • Landis, E. M.: Micro-injection studies of capillary permeability. II. Relationship between capillary pressure and the rate at which fluid passes through the walls of single capillaries. Amer. J. Physiol. 82, 217–238 (1927)

    Google Scholar 

  • Landis, E. M.: Micro-injection studies of capillary permeability. III. The effect of lack of oxygen on the permeability of the capillary wall to fluid and to the plasma proteins. Amer. J. Physiol. 83, 528–542 (1928)

    Google Scholar 

  • Lee, J. S., Smaje, L. H., Zweifach, B. W.: Fluid movement in occluded single capillaries of rabbit omentum. Circ. Res. 28, 358–370 (1971)

    Google Scholar 

  • Levine, R. A.: Antidiuretic responses to exogenous adenosine 3 ′, 5′-monophosphate in man. Clin. Sci. 34, 253–260 (1968)

    Google Scholar 

  • Little, J. R., Cohen, J. J.: Effect of albumin concentration on function of isolated perfused rat kidney. Amer. J. Physiol. 226, 512–517 (1974)

    Google Scholar 

  • Løyning, E. W.: Effect of reduced perfusion pressure on intrarenal distribution of blood flow in dogs. Acta physiol. scand. 83, 191–202 (1971)

    Google Scholar 

  • Luft, F. C., Patel, V., Yum, M. N., Patel, B., Kleit, S. A.: Experimental aminoglycoside nephrotoxicity. J. Lab. clin. Med. 86, 213–220 (1975)

    Google Scholar 

  • Maddox, D. A., Deen, W. M., Brenner, B. M.: Dynamics of glomerular ultrafiltration VI. Studies in the primate. Kidney Int. 5, 271–278 (1974)

    Google Scholar 

  • Maddox, D. A., Bennett, C. M., Deen, W. M., Glassock, R. J., Knudson, D., Daugharty, T. M., Brenner, B. M.: Determinants of glomerular filtration in experimental glomerulonephritis in the rat. J. clin. Invest. 55, 305–318 (1975)

    Google Scholar 

  • Maher, J. F.: Toxic nephropathy. In: The Kidney. Brenner, B. M., Rector, Jr., F. C., (eds.). Philadelphia: W. B. Saunders and Co. 1976, pp. 1355–1395

    Google Scholar 

  • Manning, M., Balaspiri, L., Acosta, M.: Sawyer, W. H.: Solid phase synthesis of [1-deamino, 4-valine]-8-D-arginine vasopressin (DVDAVP), a highly potent and specific antidiuretic agent possessing protracted effects. J. med. Chem. 16, 975–978 (1973)

    Google Scholar 

  • McCrory, W. M., In: Developmental Nephrology. Cambridge, MA: Harvard Univ. Press 1972

    Google Scholar 

  • Myers, B. D., Deen, W. M., Brenner, B. M.: Effects of norepinephrine and angiotensin II on the determinants of glomerular ultrafiltration and proximal tubule fluid reabsorption in the rat. Circulat. Res. 37, 101–110 (1975a)

    Google Scholar 

  • Myers, B. D., Deen, W. M., Robertson, C. R., Brenner, B. M.: Dynamics of glomerular ultrafiltration in the rat. VIII. Effects of hematocrit. Circulat. Res. 36, 425–435 (1975b)

    Google Scholar 

  • Nash, F. D., Selkurt, E. E.: Effects of elevated ureteral pressure on renal blood flow. Circ. Res. 15, Supp. 1, 1–142–1–146 (1964)

    Google Scholar 

  • Nizet, A.: Influence of serumalbumin and dextran on sodium and water excretion by the isolated dog kidney. Pflüegers Arch. ges. Physiol. 301, 7–15 (1968)

    Google Scholar 

  • O'Connor, W. J., Summerill, R. A.: The effect of a meal of meat on glomerular filtration rate in dogs at normal urine flows. J. Physiol. (Lond.) 256, 81–91 (1976)

    Google Scholar 

  • Orloff, J., Handler, J. S.: The similarity of effects of vasopressin, adenosine-3′, 5′-phosphate (cyclic AMP) and theophylline on the toad bladder. J. clin. Invest. 41, 702–709 (1962)

    Google Scholar 

  • Ott, C. E., Knox, F. G.: Effect of increased renal plasma flow on glomerular dynamics in the dog. Amer. Soc. Nephrol. 8, 91 (1975). Abstract

    Google Scholar 

  • Papadopoulou, Z. L., Slotkoff, L. M., Eisner, G. M., Lilienfield, L. S.: Glomerular filtration during stop-flow. Proc. Soc. exp. Biol. (N.4.) 130, 1206–1211 (1969)

    Google Scholar 

  • Regoli, D., Gauthier, R.: Site of action of angiotensin and other vasoconstrictors on the kidney. Canad. J. Physiol. Pharmacol. 49, 608–612 (1971)

    Google Scholar 

  • Reinhardt, H. W., Kaczmarczyk, G., Fahrenhorst, K., Blendinger, I., Gatzka, M., Kuhl, U., Riedel, J.: Postprandial changes of renal blood flow. Studies on conscious dogs on a high and low sodium intake. Pflüegers Arch. ges. Physiol. 354, 287–297 (1975)

    Google Scholar 

  • Richards, A. N., Plant, O. H.: Urine formation in the perfused kidney. The influence of adrenaline on the volume of the perfused kidney. Amer. J. Physiol. 59, 184–190 (1922)

    Google Scholar 

  • Robertson, C. R., Deen, W. M., Troy, J. L., Brenner, B. M.: Dynamics of glomerular ultrafiltration in the rat. III. Hemodynamics and autoregulation. Amer. J. Physiol. 223, 1191–1200 (1972)

    Google Scholar 

  • Ryan, G. B., Karnovsky, M. J.: An ultrastructural study of the mechanisms of pro-teinuria in aminonucleoside nephrosis. Kidney Int. 8, 219–232 (1975)

    Google Scholar 

  • Sawyer, W. H.: Effect of posterior pituitary extracts on urine formation and glomerular circulation in the frog. Amer. J. Physiol. 164, 457–466 (1951)

    Google Scholar 

  • Sawyer, W. H., Acosta, M., Balaspiri, L., Judd, J., Manning, M.: Structural changes in the arginine vasotocin molecule that enhance antidiuretic activity and specificity. Endocrinology 94, 1106–1115 (1974)

    Google Scholar 

  • Schultz, R. G., Weisser, F., Rolf, D., White, R., Bricker, N. S.: Superficial nephron function in uremia. Clin. Res. 18, 515 (1970). Abstract

    Google Scholar 

  • Selkurt, E. E., Hall, P. W., Spencer, M. P.: Influence of graded arterial pressure decrement on renal clearance of creatinine, p-amino-hippurate and sodium. Amer. J. Physiol. 159,369–378 (1949)

    Google Scholar 

  • Shea, S. M., Morrison, A. B.: A stereological study of the glomerular filter in the rat. Morphometry of the slit diaphragm and basement membrane. J. cell. Biol. 67, 436–443 (1975)

    Google Scholar 

  • Shipley, R. E., Study, R. S.: Changes in renal blood flow, extraction of inulin, glomerular filtration rate, tissue pressure and urine flow with acute alteration of renal artery blood pressure. Amer. J. Physiol. 167, 676–688 (1951)

    Google Scholar 

  • Smaje, L., Zweifach, B. W., Intaglietta, M.: Micropressures and capillary filtration coefficients in single vessels of the cremaster muscle of the rat. Microvasc. Res. 2, 96–110 (1970)

    Google Scholar 

  • Smith, H. W.: in: The Kidney. Structure and Function in Health and Disease. New York: Oxford University Press 1951

    Google Scholar 

  • Smith, H. W., Chasis, H., Goldring, W., Ranges, H. A.: Glomerular dynamics in the normal human kidney. J. clin. Invest. 19, 751–764 (1940)

    Google Scholar 

  • Smythe, C. M., Nickel, J. F., Bradley, S. E.: Effects of epinephrine (USP), L-epinephrine, and L-norepinephrine on glomerular filtration rate, renal plasma flow, and the urinary excretion of sodium, potassium and water in normal man. J. clin. Invest. 31, 499–506 (1952)

    Google Scholar 

  • Spitzer, A., Edelmann, C. M.: Maturational changes in pressure gradients for glomerular filtration. Amer. J. Physiol. 221, 1431–1435 (1971)

    Google Scholar 

  • Surtshin, A., Mueller, C. B., White, H. L.: Effect of acute changes in GFR on water and electrolyte excretion: mechanism of denervation diuresis. Amer. J. Physiol. 109, 159–173 (1952)

    Google Scholar 

  • Thurau, K.: Renal hemodynamics. Amer. J. Med. 36, 698–719 (1964)

    Google Scholar 

  • Tucker, B. J., Blantz, R. C.: Factors determining superficial nephron filtration rate (SNGFR) with growth in the Munich-Wistar rat. Fed. Proc. 35, 370 (1976). Abstract

    Google Scholar 

  • Venkatachalam, M. A., Karnovsky, M. J., Cotran, R. S.: Glomerular permeability: ultrastructural studies in experimental nephrosis using horseradish peroxidase as a tracer. J. exp. Med. 130, 381–399 (1969)

    Google Scholar 

  • Vereerstraeten, P., Toussaint, C.: Effects of plasmapheresis on renal hemodynamics and sodium excretion in dogs. Pflüegers Arch. ges. Physiol. 306, 92–102 (1969)

    Google Scholar 

  • Waugh, W. H.: Circulatory autoregulation in the fully isolated kidney and in the humorally supported isolated kidney. Circulat. Res. 15, Supp. 1, 1–156–1–169 (1964)

    Google Scholar 

  • Weinman, E. J., Renquist, K., Stroup, R., Kashagarian, M., Hayslett, J. P.: Increased tubular reabsorption of sodium in compensatory renal growth. Amer. J. Physiol. 224, 565–571 (1973)

    Google Scholar 

  • Wiederhielm, C. A., Woodbury, J. W., Kirk, S., Rushmer, R. F.: Pulsatile pressures in the microcirculation of frog's mesentery. Amer. J. Physiol. 207, 173–176 (1964)

    Google Scholar 

  • Wilfert, J. N., Burke, J. P., Bloomer, H. A., Smith, C. B.: Renal insufficiency associated with gentamicin therapy. J. infect. Dis. 124, Supp. S148–S153 (1971)

    Google Scholar 

  • Willis, L. R., Ludens, J. H., Hook, J. B., Williamson, H. E.: Mechanism of natriuretic action of bradykinin. Amer. J. Physiol. 217, 1–5 (1969)

    Google Scholar 

  • Wilson, D. R.: Micropuncture study of chronic obstructive nephropathy before and after release of occlusion. Kidney Int. 2, 119–130 (1972)

    Google Scholar 

  • Wolgast, M.: Studies on the regional renal blood flow with P32 labelled red cells and small beta-sensitive semiconductor detectors. Acta physiol. scand. Suppl. 313, 7–109 (1968)

    Google Scholar 

  • Wright, F. S., Giebisch, G.: Glomerular filtration in single nephrons. Kidney Int. 1, 201–209 (1972)

    Google Scholar 

  • Zimmerman, B. G., Abboud, F. M., Eckstein, J. W.: Effects of norepinephrine and angiotensin on total and venous resistance in the kidney. Amer. J. Physiol. 206, 701–706 (1964)

    Google Scholar 

  • Zweifach, B. W., Intaglietta, M.: Mechanics of fluid movement across single capillaries in the rabbit. Microvasc. Res. 1, 83–101 (1968)

    Google Scholar 

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© 1978 Springer-Verlag

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Baylis, C., Brenner, B.M. (1978). The physiologic determinants of glomerular ultrafiltration. In: Reviews of Physiology, Biochemistry and Pharmacology, Volume 80. Reviews of Physiology, Biochemistry and Pharmacology, vol 80. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3540084665_1

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