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Structural Diversity in Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation Reactions

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Organometallics in Process Chemistry

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 65))

Abstract

In this review, we focus on synthetic applications of asymmetric transfer hydrogenation (ATH) of structurally complex ketone and imine substrates towards the synthesis of biologically active molecules and natural products with high levels of diastereo- and enantioselectivity. This approach should be interesting to a large scientific community from both academic and industrial assets, and specially life-science businesses. Commercial supply of catalysts is key for industrial groups aiming to implement this technology in their production campaigns. Thus, relevant examples of industrial use of ATH are described.

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Notes

  1. 1.

    While small-scale samples of ATH catalysts can be obtained by catalogue companies, Ru ATH catalysts figure prominently in the offer of large catalysts suppliers such as Johnson Matthey, Umicore, and Takasago.

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Authors and Affiliations

  1. Johnson Matthey Plc, Cambridge, UK

    Garazi Talavera, Alejandro Santana Fariña, Antonio Zanotti-Gerosa & Hans Günter Nedden

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  1. Garazi Talavera
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  2. Alejandro Santana Fariña
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  4. Hans Günter Nedden
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  1. MilliporeSigma (A business of Merck KGaA, Darmstadt, Germany), Milwaukee, WI, USA

    Thomas J. Colacot

  2. Johnson Matthey, Taloja, Maharashtra, India

    Vilvanathan Sivakumar

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Talavera, G., Santana Fariña, A., Zanotti-Gerosa, A., Nedden, H.G. (2019). Structural Diversity in Ruthenium-Catalyzed Asymmetric Transfer Hydrogenation Reactions. In: Colacot, T., Sivakumar, V. (eds) Organometallics in Process Chemistry. Topics in Organometallic Chemistry, vol 65. Springer, Cham. https://doi.org/10.1007/3418_2019_27

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