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Enantioselective Organometallic Catalysis in Flow

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Organometallic Flow Chemistry

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 57))

Abstract

Enantioselective chemical transformations using chiral metal catalysts under continuous-flow conditions are described. Although flow methods have several advantages over batch methods in terms of environmental compatibility, efficiency, and safety, synthesis by flow methods is more difficult than by batch methods. Some pioneering efforts on the topic were conducted in the early 1990s; major contributions have been started very recently. While some fruitful results have been reported in enantioselective hydrogenation, other reactions such as enantioselective oxidation, C–X bond formation, and C–C bond formation are still limited. More advances is expected because flow methods are leading candidates for the next generation of manufacturing methods that can mitigate environmental concerns.

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Authors and Affiliations

  1. Green and Sustainable Chemistry Social Cooperation Laboratory, Graduate School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Haruro Ishitani & Shū Kobayashi

  2. Department of Chemistry, School of Science, The University of Tokyo, Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan

    Yuki Saito & Shū Kobayashi

Authors
  1. Haruro Ishitani
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  2. Yuki Saito
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  3. Shū Kobayashi
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Corresponding author

Correspondence to Shū Kobayashi .

Editor information

Editors and Affiliations

  1. Micro Flow Chemistry and Process Technology, Eindhoven University of Technology, Eindhoven, The Netherlands

    Timothy Noël

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Ishitani, H., Saito, Y., Kobayashi, S. (2016). Enantioselective Organometallic Catalysis in Flow. In: Noël, T. (eds) Organometallic Flow Chemistry. Topics in Organometallic Chemistry, vol 57. Springer, Cham. https://doi.org/10.1007/3418_2016_167

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