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Metal-Catalyzed C(sp2)–N Bond Formation

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Amination and Formation of sp2 C-N Bonds

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 46))

Abstract

During the last decades a powerful set of protocols featuring C(sp2)–N bond formation have emerged as convenient alternatives for the assembly of enamine and enamides. Those methods consist of mostly palladium-catalyzed oxidative amidations of alkenes and both palladium- and copper-catalyzed cross-couplings between generally vinyl halides or pseudohalides and amines or amides. In this review recent advances in both types of processes will be disclosed. Additionally, the synthetic value of the title processes will be illustrated by describing relevant total syntheses of natural products involving vinylation process as the key step.

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Acknowledgments

A.C. thanks the Basque Government for being supported by “Programa de Perfeccionamiento de Doctores en el extranjero del Departamento de Educación, Universidades e Investigación.” The authors are also grateful to the Fonds der Chemischen Industrie for continuous support.

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Authors and Affiliations

  1. Institute of Organic Chemistry, RWTH Aachen University, Landoltweg 1, 52056, Aachen, Germany

    Arkaitz Correa & Carsten Bolm

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  1. Arkaitz Correa
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  2. Carsten Bolm
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Correspondence to Carsten Bolm .

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Editors and Affiliations

  1. Ecole Nationale Superieure de Chimie (CNRS), Montpellier, France

    Marc Taillefer

  2. Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, People's Republic of China

    Dawei Ma

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Correa, A., Bolm, C. (2012). Metal-Catalyzed C(sp2)–N Bond Formation. In: Taillefer, M., Ma, D. (eds) Amination and Formation of sp2 C-N Bonds. Topics in Organometallic Chemistry, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3418_2012_57

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