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Asymmetric Hydrogenation

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Organometallics as Catalysts in the Fine Chemical Industry

Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 42))

Abstract

This review describes the application of chiral organometallic catalysts for the enantioselective (transfer) hydrogenation of C=C, C=O and C=N bonds in the fine chemicals industry. Covered are processes that have been and/or are presently used for the commercial manufacture of chiral compounds as well as selected pilot and bench-scale processes not (yet) used in production. The review is organized according to the metal precursor actually employed in the hydrogenation reactions. Described are large scale applications of Rh, Ru, and Ir complexes with chiral P^P, P^N and N^N ligands, either used as preformed, isolated complexes or as in situ-prepared catalyst precursors.

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Authors and Affiliations

  1. Solvias AG, Römerpark 2, CH-4303, Kaiseraugst, Switzerland

    Hans-Ulrich Blaser, Benoît Pugin & Felix Spindler

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  1. Hans-Ulrich Blaser
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  2. Benoît Pugin
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Correspondence to Hans-Ulrich Blaser .

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  1. Leibniz-Institut für, Organische Katalyse, Universität Rostock, Albert-Einstein-Str. 29, Rostock, 18059, Germany

    Matthias Beller

  2. Furglerstrasse 10, St. Gallen, 9000, Switzerland

    Hans-Ulrich Blaser

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Blaser, HU., Pugin, B., Spindler, F. (2012). Asymmetric Hydrogenation. In: Beller, M., Blaser, HU. (eds) Organometallics as Catalysts in the Fine Chemical Industry. Topics in Organometallic Chemistry, vol 42. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3418_2011_27

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