Abstract
Asymmetric allylic substitutions catalyzed by molybdenum and tungsten complexes provide branched chiral products from unsymmetrically substituted allylic reagents. Highly selective chiral ligands are available for both types of reactions, but for the tungsten-catalyzed substitutions, enantioselective reactions are only possible starting from achiral linear allylic substrates. A variety of stabilized carbanions can be used as nucleophiles. The molybdenum-catalyzed reaction has been applied to the synthesis of several biologically active compounds.
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Abbreviations
- b:
-
Branched
- Bipy:
-
Bipyridine
- Boc:
-
tert-Butoxycarbonyl
- l:
-
Linear
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Moberg, C. (2011). Molybdenum-Catalyzed and Tungsten-Catalyzed Enantioselective Allylic Substitutions. In: Kazmaier, U. (eds) Transition Metal Catalyzed Enantioselective Allylic Substitution in Organic Synthesis. Topics in Organometallic Chemistry, vol 38. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3418_2011_11
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DOI: https://doi.org/10.1007/3418_2011_11
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