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Directed Metallation pp 85–116Cite as

Chelate-Directed Oxidative Functionalization of Carbon–Hydrogen Bonds: Synthetic Applications and Mechanistic Insights

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Part of the book series: Topics in Organometallic Chemistry ((TOPORGAN,volume 24))

Abstract

This chapter describes advances over the past four decades in Pd-mediated and Pd-catalyzed reactions for the highly regioselective oxidative functionalization of C–H bonds. The synthetic utility and the key mechanistic features of both stoichiometric and catalytic C–X (X = O, Cl, Br, I, F, N) bond-forming reactions are presented. The intermediacy of high oxidation state PdIV species in many of these transformations has allowed for bond constructions that were not previously possible through traditional Pd0/PdII couples.

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Authors and Affiliations

  1. Department of Chemistry, University of Michigan, 930 North University Ave., 48109, Ann Arbor, MI, USA

    Dipannita Kalyani & Melanie S. Sanford

Authors
  1. Dipannita Kalyani
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  2. Melanie S. Sanford
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Corresponding author

Correspondence to Melanie S. Sanford .

Editor information

Naoto Chatani

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© 2007 Springer-Verlag Berlin Heidelberg

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Kalyani, D., Sanford, M.S. (2007). Chelate-Directed Oxidative Functionalization of Carbon–Hydrogen Bonds: Synthetic Applications and Mechanistic Insights. In: Chatani, N. (eds) Directed Metallation. Topics in Organometallic Chemistry, vol 24. Springer, Berlin, Heidelberg. https://doi.org/10.1007/3418_2007_068

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