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Chelate-Directed Oxidative Functionalization of Carbon–Hydrogen Bonds: Synthetic Applications and Mechanistic Insights

  • Dipannita Kalyani
  • Melanie S. SanfordEmail author
Chapter
First Online:
Part of the Topics in Organometallic Chemistry book series (TOPORGAN, volume 24)

Abstract

This chapter describes advances over the past four decades in Pd-mediated and Pd-catalyzed reactions for the highly regioselective oxidative functionalization of C–H bonds. The synthetic utility and the key mechanistic features of both stoichiometric and catalytic C–X (X = O, Cl, Br, I, F, N) bond-forming reactions are presented. The intermediacy of high oxidation state PdIV species in many of these transformations has allowed for bond constructions that were not previously possible through traditional Pd0/PdII couples.

C–H bond cleavage Chelation Carbon–heteroatom Palladium Palladium(IV)  
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Copyright information

© Springer-Verlag Berlin Heidelberg 2007

Authors and Affiliations

  1. 1.Department of ChemistryUniversity of MichiganAnn ArborUSA

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