Concluding remarks
The current concept of lymphocyte migration to the kidney that has resulted in a better conceptual understanding of progressive renal diseases has been briefly summarized. Our understanding of the molecules involved in the pathogenesis of various renal diseases may provide new therapeutic choices, and lead to the discovery of gene-based therapeutic options. It is likely that selective intervention of chemokines, at the appropriate phase of a particular disease, may have the therapeutic potential for site- and phase-specific intervention of lymphocyte migration and the progression of renal diseases.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Jones DB (1953) Glomerulonephritis. Am J Pathol 29: 33–43
Wada T, Razzaque MS, Matsushima K, Taguchi T, Yokoyama H (2004) Pathological significance of renal expression of proinflammatory molecules. In: MS Razzaque (ed): Fibrogenesis: Cellular and molecular basis. Landes Bioscience Eurekah, Georgetown, 9–26
Wolpe SD, Davatelis G, Sherry B, Beutler B, Hesse DG, Nguyen HT, Moldawer LL, Nathan CF, Lowry SF, Cerami A (1988) Macrophages secrete a novel heparin-binding protein with inflammatory and neutrophil chemotactic properties. J Exp Med 167:570–580
van Rooijen N, Sanders A (1997) Elimination, blocking, and activation of macrophages: three of a kind? J Leukoc Biol 62: 702–709
Wang JM, Griffin JD, Rambaldi A, Chen ZG, Mantovani A (1988) Induction of monocyte migration by recombinant macrophage colony-stimulating factor. J Immunol 141:575–579
Lan HY, Nikolic-Paterson DJ, Mu W, Atkins RC (1995) Local macrophage proliferation in the progression of glomerular and tubulointerstitial injury in rat anti-GBM glomerulonephritis. Kidney Int 48: 753–760
Matsuda M, Shikata K, Makino H, Sugimoto H, Ota Z (1996) Glomerular expression of macrophage colony-stimulating factor and granulocyte-macrophage colony-stimulating factor in patients with various forms of glomerulonephritis. Lab Invest 75: 403–412
Razzaque MS, Foster CS, Ahmed AR (2002) Role of enhanced expression of M-CSF in conjunctiva affected by cicatricial pemphigoid. Invest Ophthalmol Vis Sci 43:2977–2983
Lan HY, Yang N, Nikolic-Paterson DJ, Yu XQ, Mu W, Isbel NM, Metz CN, Bucala, R, Atkins RC (2000) Expression of macrophage migration inhibitory factor in human glomerulonephritis. Kidney Int 57: 499–509
Yang N, Nikolic-Paterson DJ, Ng YY, Mu W, Metz C, Bacher M, Meinhardt A, Bucala R, Atkins RC, Lan HY (1998) Reversal of established rat crescentic glomerulonephritis by blockade of macrophage migration inhibitory factor (MIF): potential role of MIF in regulating glucocorticoid production. Mol Med 4: 413–424
Wada T, Schwarting A, Chesnutt MS, Wofsy D, Kelley VR (2001) Nephritogenic cytokines and disease in MRL-Fas lpr kidneys are dependent on multiple T cell subsets. Kidney Int 59: 565–578
Imasawa T, Utsunomiya Y, Kawamura T, Zhong Y, Nagasawa R, Okabe M, Maruyama N, Hosoya T, Ohno T (2001) The potential of bone marrow-derived cells to differentiate to glomerular mesangial cells. J Am Soc Nephrol 12: 1401–1409
Ito T, Suzuki A, Imai E, Okabe M, Hori M (2001) Bone marrow is a reservoir of repopulating mesangial cells during glomerular remodeling. J Am Soc Nephrol 12: 2625–2635
Wada T, Yokoyama H, Matsushima K, Kobayashi K (2001) Chemokines in renal diseases. Int Immunopharmacol 1: 637–645
Wada T, Matsushima K, Yokoyama H (2003) Chemokines as therapeutic targets for renal diseases. Curr Med Chem Anti-Inflammatory Anti-Allergy Agents 2: 175–190
Furuichi K, Wada T, Sakai N, Iwata Y, Yoshimoto K, Shimizu M, Kobayashi K, Takasawa K, Kida H, Takeda S et al (2000) Distinct expression of CCR1 and CCR5 in glomerular and interstitial lesions of human glomerular diseases. Am J Nephrol 20:291–299
Moore KJ, Wada T, Barbee SD, Kelley VR (1998) Gene transfer of RANTES elicits autoimmune renal injury in MRL-Fas lpr mice. Kidney Int 53: 1631–1641
Luo Y, Lloyd C, Gutierrez-Ramos JC, Dorf ME (1999) Chemokine amplification in mesangial cells. J Immunol 163: 3985–3992
Morigi M, Imberti B, Zoja C, Corna D, Tomasoni S, Abbate M, Rottoli D, Angioletti S, Benigni A, Perico N et al (2004) Mesenchymal stem cells are renotropic, helping to repair the kidney and improve function in acute renal failure. J Am Soc Nephrol 15:1794–1804
Togel F, Isaac J, Hu Z, Weiss K, Westenfelder C (2005) Renal SDF-1 signals mobilization and homing of CXCR4-positive cells to the kidney after ischemic injury. Kidney Int 67: 1772–1784
Yokoo T, Ohashi T, Shen JS, Sakurai K, Miyazaki Y, Utsunomiya Y, Takahashi M, Terada Y, Eto Y, Kawamura T et al (2005) Human mesenchymal stem cells in rodent wholeembryo culture are reprogrammed to contribute to kidney tissues. Proc Natl Acad Sci USA 102: 3296–3300
Wada T, Furuichi K, Segawa C, Shimizu M, Sakai N, Takeda S, Takasawa K, Kida H, Kobayashi, K, Mukaida N et al (1999) MIP-1α and MCP-1 contribute crescents and interstitial lesions in human crescentic glomerulonephritis. Kidney Int 56: 995–1003
Sakai N, Wada T, Furuichi K, Kitagawa K, Kokubo S, Kobayashi M, Takeda S, Kida H, Kobayashi K, Mukaida N et al (2002) p38 MAPK phosphorylation and NF-κB activation in human crescentic glomerulonephritis. Nephrol Dial Transplant 17: 998–1004
Wada T, Furuichi K, Sakai N, Hisada Y, Kobayashi K, Tomosugi N, Mukaida N, Matsushima K, Yokoyama H (2001) Involvement of p38 mitogen-activated protein kinase followed by chemokine expression in crescentic glomerulonephritis. Am J Kidney Dis 38: 1169–1177
Wada T, Furuichi K, Sakai N, Iwata Y, Yoshimoto K, Shimizu M, Kobayashi K, Matsushima K, Yokoyama H (2000) A new anti-inflammatory compound, FR167653, ameliorates crescentic glomerulonephritis in Wistar-Kyoto rats. J Am Soc Nephrol 11:1534–1541
Wada T, Yokoyama H, Furuichi K, Kobayashi K, Harada K, Naruto M, Su SB, Akiyama, M, Mukaida N, Matsushima (1996) Intervention of crescentic glomerulonephritis by antibodies to monocyte chemotactic and activating factor (MCAF/MCP-1). FASEB J 10: 1418–1425
Wu X, Dolecki GJ, Sherry B, Zagorski J, Lefkowith JB (1997) Chemokines are expressed in a myeloid cell-dependent fashion and mediate distinct functions in immune complex glomerulonephritis in rat. J Immunol 158: 3917–3924
Tesch GH, Schwarting A, Kinoshita K, Lan HY, Rollins BJ, Kelley VR (1999) Monocyte chemoattractant protein-1 promotes macrophage-mediated tubular injury, but not glomerular injury, in nephrotoxic serum nephritis. J Clin Invest 103: 73–80
Lloyd CM, Minto AW, Dorf ME, Proudfoot A, Wells TN, Salant DJ, Guiterrez-Ramos JC (1997) RANTES and monocyte chemoattractant protein-1 (MCP-1) play an important role in the inflammatory phase of crescentic nephritis, but only MCP-1 is involved in crescent formation and interstitial fibrosis. J Exp Med 185: 1371–1380
Topham PS, Csizmadia V, Soler D, Hines D, Gerard CJ, Salant DJ, Hancock WW (1999) Lack of chemokine receptor CCR1 enhances Th1 responses and glomerular injury during nephrotoxic nephritis. J Clin Invest 104: 1549–1557
Wada T, Yokoyama H, Su SB, Mukaida N, Iwano M, Dohi K, Takahashi Y, Sasaki T, Furuichi K, Segawa C et al (1996) Monitoring urinary levels of monocyte chemotactic and activating factor reflects disease activity of lupus nephritis. Kidney Int 49: 761–767
Zoja C, Liu XH, Donadelli R, Abbate M, Testa D, Corna D, Taraboletti G, Vecchi A, Dong QG, Rollins BJ et al (1997) Renal expression of monocyte chemoattractant protein-1 in lupus autoimmune mice. J Am Soc Nephrol 8: 720–729
Wada T, Naito T, Griffiths RC, Coffman TM, Kelley VR (1997) Systemic autoimmune nephritogenic components induce CSF-1 and TNF-alpha in MRL kidneys. Kidney Int 52: 934–941
Wada T, Schwarting A, Kinoshita K, Naito T, Griffiths RC, Coffman TMR, Kelley VR (1999) Fas on renal parenchymal cells does not accelerate autoimmune nephritis in MRL mice. Kidney Int 55: 841–851
Tesch GH, Maifert S, Schwarting A, Rollins BJ, Kelley VR (1999) Monocyte chemoattractant protein 1-dependent leukocytic infiltrates are responsible for autoimmune disease in MRL-Fas lpr mice. J Exp Med 190: 1813–1824
Shimizu S, Nakashima H, Karube K, Ohshima K, Egashira K (2005) Monocyte chemoattractant protein-1 activates a regional Th1 immunoresponse in nephritis of MRL/lpr mice. Clin Exp Rheumatol 23: 239–242
Perez de Lema G, Maier H, Nieto E, Vielhauer V, Luckow B, Mampaso F, Schlöndorff D (2001) Chemokine expression precedes inflammatory cell infiltration and chemokine receptor and cytokine expression during the initiation of murine lupus nephritis. J Am Soc Nephrol 12: 1369–1382
Ishikawa S, Sato T, Abe M, Nagai S, Onai N, Yoneyama H, Zhang Y, Suzuki T, Hashimoto S, Shirai T et al (2001) Aberrant high expression of B lymphocyte chemokine (BLC/CXCL13) by C11b+CD11c+ dendritic cells in murine lupus and preferential chemotaxis of B1 cells towards BLC. J Exp Med 193: 1393–1402
Yamada M, Yagita H, Inoue H, Takanashi T, Matsuda H, Munechika E, Kanamaru Y, Shirato I, Tomino Y, Matsushima K et al (2002) Selective accumulation of CCR4+ T lymphocytes into renal tissue of patients with lupus nephritis. Arthritis Rheum 46:735–740
Inoue A, Hasegawa H, Kohno M, Ito MR, Terada M, Imai T, Yoshie O, Nose M, Fujita S (2005) Antagonist of fractalkine (CX3CL1) delays the initiation and ameliorates the progression of lupus nephritis in MRL/lpr mice. Arthritis Rheum 52: 1522–1533
Wada T, Furuichi K, Sakai N, Iwata Y, Yoshimoto K, Shimizu M, Takeda S, Takasawa K, Yoshimura M, Kida H et al (2000) Up-regulation of monocyte chemoattractant protein-1 in tubulointerstitial lesions of human diabetic nephropathy. Kidney Int 58:1492–1498
Moriya R, Manivel JC, Mauer M (2004) Juxtaglomerular apparatus T-cell infiltration affects glomerular structure in Type 1 diabetic patients. Diabetologia 47: 82–88
Kato S, Luyckx VA, Ots M, Lee KW, Ziai F, Troy JL, Brenner BM, MacKenzie HS (1999) Renin-angiotensin blockade lowers MCP-1 expression in diabetic rats. Kidney Int 56: 1037–1048
Parving HH, Lehnert H, Brochner-Mortensen J, Gomis R, Andersen S, Arner P (2001) The effect of irbesartan on the development of diabetic nephropathy in patients with type 2 diabetes. N Engl J Med 345: 870–878
Brenner BM, Cooper ME, de Zeeuw D, Keane WF, Mitch WE, Parving HH, Remuzzi G, Snapinn SM, Zhang Z, Shahinfar S (2001) Effects of losartan on renal and cardiovascular outcomes in patients with type 2 diabetes and nephropathy. N Engl J Med 345:861–869
Nakao N, Yoshimura A, Morita H, Takada M, Kayano T, Ideura T (2003) Combination treatment of angiotensin-II receptor blocker and angiotensin-converting-enzyme inhibitor in non-diabetic renal disease (COOPERATE): a randomised controlled trial. Lancet 361: 117–124
Utimura R, Fujihara CK, Mattar AL, Malheiros DM, De Lourdes Noronha I, Zatz R (2003) Mycophenolate mofetil prevents the development of glomerular injury in experimental diabetes. Kidney Int 63: 209–216
Yozai K, Shikata K, Sasaki M, Tone A, Ohga S, Usui H, Okada S, Wada J, Nagase R, Ogawa D et al (2005) Methotrexate prevents renal injury in experimental diabetic rats via anti-inflammatory actions. J Am Soc Nephrol 16: 3326–3338
Pascual M, Theruvath T, Kawai T, Tolkoff-Rubin NM, Cosimi AB (2002) Strategies to improve long-term outcomes after renal transplantation. N Engl J Med 346: 580–590
Grone HJ, Weber C, Weber KS, Grone EF, Rabelink T, Klier CM, Wells TN, Proudfood AE, Schlöndorff D et al (1999) Met-RANTES reduces vascular and tubular damage during acute renal transplant rejection: blocking monocyte arrest and recruitment. FASEB J 13: 1371–1383
Strehlau J, Pavlakis M, Lipman M, Shapiro M, Vasconcellos L, Harmon W, Strom TB (1997) Quantitative detection of immune activation transcripts as a diagnostic tool in kidney transplantation. Proc Natl Acad Sci USA 94: 695–700
Nagano H, Nadeau KC, Takada M, Kusaka M, Tilney NL (1997) Sequential cellular and molecular kinetics in acutely rejecting renal allografts in rats. Transplantation 63:1101–1108
Azuma H, Takahara S, Matsumoto K, Ichimaru N, Wang JD, Moriyama T, Waaga AM, Kitamura M, Otsuki Y, Okuyama A et al (2001) Hepatocyte growth factor prevents the development of chronic allograft nephropathy in rats. J Am Soc Nephrol 12: 1280–1292
Azuma H, Wada T, Gotoh R, Furuichi K, Sakai N, Yazawa K, Yokoyama H, Katsuoka Y, Takahara S (2003) Combined therapy of FR167653 and CsA significantly prolonged animal survival in rat renal allografts. Transplantation 76: 1029–1036
Song E, Zou H, Yao Y, Proudfoot A, Antus B, Liu S, Jens L, Heemann U (2002) Early application of Met-RANTES ameliorates chronic allograft nephropathy. Kidney Int 61:676–685
Grandaliano G, Gesualdo L, Ranieri E, Monno R, Stallone G, Schena FP (1997) Monocyte chemotactic peptide-1 expression and monocyte infiltration in acute renal transplant rejection. Transplantation 63: 414–420
Suleiman M, Cury PM, Pestana JQ, Burdmann EA, Bueno V (2005) FTY720 prevents renal T-cell infiltration after ischemia/reperfusion injury. Transplant Proc 37: 373–374
Steinmetz OM, Panzer U, Kneissler U, Harendza S, Lipp M, Helmchen U, Stahl RA (2005) BCA-1/CXCL13 expression is associated with CXCR5-positive B-cell cluster formation in acute renal transplant rejection. Kidney Int 67: 1616–1621
Kerjaschki D, Regele HM, Moosberger I, Nagy-Bojarski K, Watschinger B, Soleiman A, Birner P, Krieger S, Hovorka A, Silberhumer G et al (2004) Lymphatic neoangiogenesis in human kidney transplants is associated with immunologically active lymphocytic infiltrates. J Am Soc Nephrol 15: 603–612
Romagnani P, Lazzeri E, Lasagni L, Mavilia C, Beltrame C, Francalanci M, Rotondi M, Annunziato F, Maurenzig L et al (2002) IP-10 and Mig production by glomerular cells in human proliferative glomerulonephritis and regulation by nitric oxide. J Am Soc Nephrol 13: 53–64
Banas B, Wornle M, Berger T, Nelson PJ, Cohen CD, Kretzler M, Pfirstinger J, Mack M, Li M, Grone HJ, Schlöndorff D (2002) Roles of SLC/CCL21 and CCR7 in human kidney for mesangial proliferation, migration, apoptosis, and tissue homeostasis. J Immunol 168:4301–4307
Wada T, Tomosugi N, Naito T, Yokoyama H, Kobayashi K, Mukaida N, Matsushima K (1994) Prevention of proteinuria by the administration of anti-interleukin 8 antibody in experimental acute immune complex-induced glomerulonephritis. J Exp Med 180:1135–1140
Huber TB, Reinhardt HC, Exner M, Burger JA, Kerjaschki D, Saleem MA, Pavenstadt H (2002) Expression of functional CCR and CXCR chemokine receptors in podocytes. J Immunol 168:6244–6252
Wada T, Furuichi K, Sakai N, Iwata Y, Kitagawa K, Ishida Y, Kondo T, Hashimoto H, Ishiwata Y, Mukaida N et al (2004) Gene therapy via blockade of MCP-1 for renal fibrosis. J Am Soc Nephrol 15: 940–948
Kitagawa K, Wada T, Furuichi K, Hashimoto H, Ishiwata Y, Kuziel WA, Matsushima K, Muikad N, Yokoyama H (2004) Blockade of CCR2 ameliorates renal fibrosis. Am J Pathol 165: 237–246
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2006 Birkhäuser Verlag Basel/Switzerland
About this chapter
Cite this chapter
Wada, T., Yokoyama, H., Kaneko, S., Matsushima, K. (2006). Lymphocyte migration to the kidney. In: Badolato, R., Sozzani, S. (eds) Lymphocyte Trafficking in Health and Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7442-X_9
Download citation
DOI: https://doi.org/10.1007/3-7643-7442-X_9
Publisher Name: Birkhäuser Basel
Print ISBN: 978-3-7643-7308-5
Online ISBN: 978-3-7643-7442-6
eBook Packages: Biomedical and Life SciencesBiomedical and Life Sciences (R0)