Skip to main content

Endogenous regulation of toll-like receptor signalling

  • Chapter
Toll-like Receptors in Inflammation

Part of the book series: Progress in Inflammation Research ((PIR))

  • 652 Accesses

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Poltorak A, He X, Smirnova I, Liu MY, Huffel CV, Du X, Birdwell D, Alejos E, Silva M, Galanos C et al (1998) Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science 282: 2085

    Article  CAS  PubMed  Google Scholar 

  2. Underhill DM, Ozinsky A, Smith KD, Aderem A (1999) Toll-like receptor-2 mediates mycobacteria-induced proinflammatory signaling in macrophages. Proc Natl Acad Sci USA 96: 14459

    Article  CAS  PubMed  Google Scholar 

  3. Hayashi F, Smith KD, Ozinsky A, Hawn TR, Yi EC, Goodlett DR, Eng JK, Akira S, Underhill DM, Aderem A (2001) The innate immune response to bacterial flagellin is mediated by Toll-like receptor 5. Nature 410: 1099

    Article  CAS  PubMed  Google Scholar 

  4. Lund J, Sato A, Akira S, Medzhitov R, Iwasaki A (2003) Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells. J Exp Med 198: 513

    Article  CAS  PubMed  Google Scholar 

  5. Heil F, Hemmi H, Hochrein H, Ampenberger F, Kirschning C, Akira S, Lipford G, Wagner H, Bauer S (2004) Species-specific recognition of single-stranded RNA via toll-like receptor 7 and 8. Science 303: 1526

    Article  CAS  PubMed  Google Scholar 

  6. Hornung V, Schlender J, Guenthner-Biller M, Rothenfusser S, Endres S, Conzelmann KK, Hartmann G (2004) Replication-dependent potent IFN-alpha induction in human plasmacytoid dendritic cells by a single-stranded RNA virus. J Immunol 173: 5935

    CAS  PubMed  Google Scholar 

  7. Diebold SS, Kaisho T, Hemmi H, Akira S, Reis e Sousa C (2004) Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 303: 1529

    Article  CAS  PubMed  Google Scholar 

  8. Meier A, Kirschning CJ, Nikolaus T, Wagner H, Heesemann J, Ebel F (2003) Toll-like receptor (TLR) 2 and TLR4 are essential for Aspergillus-induced activation of murine macrophages. Cell Microbiol 5: 561

    Article  CAS  PubMed  Google Scholar 

  9. Campos MA, Gazzinelli RT (2004) Trypanosoma cruzi and its components as exogenous mediators of inflammation recognized through Toll-like receptors. Mediators Inflamm 13: 139

    Article  CAS  PubMed  Google Scholar 

  10. Pittet D, Rangel-Frausto S, Li N, Tarara D, Costigan M, Rempe L, Jebson P, Wenzel RP (1995) Systemic inflammatory response syndrome, sepsis, severe sepsis and septic shock: incidence, morbidities and outcomes in surgical ICU patients. Intensive Care Med 21: 302

    Article  CAS  PubMed  Google Scholar 

  11. Leadbetter EA, Rifkin IR, Hohlbaum AM, Beaudette BC, Shlomchik MJ, Marshak-Rothstein A (2002) Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature 416: 603

    Article  CAS  PubMed  Google Scholar 

  12. Viglianti GA, Lau CM, Hanley TM, Miko BA, Shlomchik MJ, Marshak-Rothstein A (2003) Activation of autoreactive B cells by CpG dsDNA. Immunity 19: 837

    Article  CAS  PubMed  Google Scholar 

  13. Kiechl S, Lorenz E, Reindl M, Wiedermann CJ, Oberhollenzer F, Bonora E, Willeit J, Schwartz DA (2002) Toll-like receptor 4 polymorphisms and atherogenesis. N Engl J Med 347: 185

    Article  CAS  PubMed  Google Scholar 

  14. Ameziane N, Beillat T, Verpillat P, Chollet-Martin S, Aumont MC, Seknadji P, Lamotte M, Lebret D, Ollivier V, de Prost D (2003) Association of the Toll-like receptor 4 gene Asp299Gly polymorphism with acute coronary events. Arterioscler Thromb Vasc Biol 23: e61

    PubMed  Google Scholar 

  15. Cook DN, Pisetsky DS, Schwartz DA (2004) Toll-like receptors in the pathogenesis of human disease. Nat Immunol 5: 975

    Article  CAS  PubMed  Google Scholar 

  16. Dripps DJ, Brandhuber BJ, Thompson RC, Eisenberg SP (1991) Interleukin-1 (IL-1) receptor antagonist binds to the 80-kDa IL-1 receptor but does not initiate IL-1 signal transduction. J Biol Chem 266: 10331

    CAS  PubMed  Google Scholar 

  17. Sims JE, Gayle MA, Slack JL, Alderson MR, Bird TA, Giri JG, Colotta F, Re F, Mantovani A, Shanebeck K et al (1993) Interleukin 1 signaling occurs exclusively via the type I receptor. Proc Natl Acad Sci USA 90: 6155

    CAS  PubMed  Google Scholar 

  18. Smith DE, Hanna R, Della F, Moore H, Chen H, Farese AM, MacVittie TJ, Virca GD, Sims JE (2003) The soluble form of IL-1 receptor accessory protein enhances the ability of soluble type II IL-1 receptor to inhibit IL-1 action. Immunity 18: 87

    Article  CAS  PubMed  Google Scholar 

  19. Qureshi ST, Lariviere L, Leveque G, Clermont S, Moore KJ, Gros P, Malo D (1999) Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J Exp Med 189: 615

    Article  CAS  PubMed  Google Scholar 

  20. Iwami KI, Matsuguchi T, Masuda A, Kikuchi T, Musikacharoen T, Yoshikai Y (2000) Cutting edge: naturally occurring soluble form of mouse Toll-like receptor 4 inhibits lipopolysaccharide signaling. J Immunol 165: 6682

    CAS  PubMed  Google Scholar 

  21. LeBouder E, Rey-Nores JE, Rushmere NK, Grigorov M, Lawn SD, Affolter M, Griffin GE, Ferrara P, Schiffrin EJ, Morgan BP, Labeta MO (2003) Soluble forms of Toll-like receptor (TLR)2 capable of modulating TLR2 signaling are present in human plasma and breast milk. J Immunol 171: 6680

    CAS  PubMed  Google Scholar 

  22. Iwaki D, Mitsuzawa H, Murakami S, Sano H, Konishi M, Akino T, Kuroki Y (2002) The extracellular toll-like receptor 2 domain directly binds peptidoglycan derived from Staphylococcus aureus. J Biol Chem 277: 24315

    Article  CAS  PubMed  Google Scholar 

  23. Thomassen E, Renshaw BR, Sims JE (1999) Identification and characterization of SIGIRR, a molecule representing a novel subtype of the IL-1R superfamily. Cytokine 11: 389

    Article  CAS  PubMed  Google Scholar 

  24. Wald D, Qin J, Zhao Z, Qian Y, Naramura M, Tian L, Towne J, Sims JE, Stark GR, Li X (2003) SIGIRR, a negative regulator of Toll-like receptor-interleukin 1 receptor signaling. Nat Immunol 4: 920

    Article  CAS  PubMed  Google Scholar 

  25. Garlanda C, Riva F, Polentarutti N, Buracchi C, Sironi M, De Bortoli M, Muzio M, Bergottini R, Scanziani E, Vecchi A, Hirsch E, Mantovani A (2004) Intestinal inflammation in mice deficient in Tir8, an inhibitory member of the IL-1 receptor family. Proc Natl Acad Sci USA 101: 3522

    Article  CAS  PubMed  Google Scholar 

  26. Klemenz R, Hoffmann S, Werenskiold AK (1989) Serum-and oncoprotein-mediated induction of a gene with sequence similarity to the gene encoding carcinoembryonic antigen. Proc Natl Acad Sci USA 86: 5708

    CAS  PubMed  Google Scholar 

  27. Tominaga S (1989) A putative protein of a growth specific cDNA from BALB/c-3T3 cells is highly similar to the extracellular portion of mouse interleukin 1 receptor. FEBS Lett 258: 301

    Article  CAS  PubMed  Google Scholar 

  28. Werenskiold AK, Hoffmann S, Klemenz R (1989) Induction of a mitogen-responsive gene after expression of the Ha-ras oncogene in NIH 3T3 fibroblasts. Mol Cell Biol 9: 5207

    CAS  PubMed  Google Scholar 

  29. Kumar S, Minnich MD, Young PR (1995) ST2/T1 protein functionally binds to two secreted proteins from Balb/c 3T3 and human umbilical vein endothelial cells but does not bind interleukin 1. J Biol Chem 270: 27905

    CAS  PubMed  Google Scholar 

  30. Gayle MA, Slack JL, Bonnert TP, Renshaw BR, Sonoda G, Taguchi T, Testa JR, Dower SK, Sims JE (1996) Cloning of a putative ligand for the T1/ST2 receptor. J Biol Chem 271: 5784

    CAS  PubMed  Google Scholar 

  31. Gachter T, Werenskiold AK, Klemenz R (1996) Transcription of the interleukin-1 receptor-related T1 gene is initiated at different promoters in mast cells and fibroblasts. J Biol Chem 271: 124

    CAS  PubMed  Google Scholar 

  32. Xu D, Chan WL, Leung BP, Huang F, Wheeler R, Piedrafita D, Robinson JH, Liew FJ (1998) Selective expression of a stable cell surface molecule on type 2 but not type 1 helper T cells. J Exp Med 187: 787

    Article  CAS  PubMed  Google Scholar 

  33. Coyle AJ, Lloyd C, Tian J, Nguyen T, Erikkson C, Wang L, Ottoson P, Persson P, Delaney T, Lehar S et al (1999) Crucial role of the interleukin 1 receptor family member T1/ST2 in T helper cell type 2-mediated lung mucosal immune responses. J Exp Med 190: 895

    Article  CAS  PubMed  Google Scholar 

  34. Kumar S, Tzimas MN, Griswold DE, Young PR (1997) Expression of ST2, an interleukin-1 receptor homologue, is induced by proinflammatory stimuli. Biochem Biophys Res Commun 235: 474

    CAS  PubMed  Google Scholar 

  35. Sweet MJ, Leung BP, Kang D, Sogaard M, Schulz K, Trajkovic V, Campbell CC, Xu D, Liew FY (2001) A novel pathway regulating lipopolysaccharide-induced shock by ST2/T1 via inhibition of Toll-like receptor 4 expression. J Immunol 166: 6633

    CAS  PubMed  Google Scholar 

  36. Kuroiwa K, Arai T, Okazaki H, Minota S, Tominaga S (2001) Identification of human ST2 protein in the sera of patients with autoimmune diseases. Biochem Biophys Res Commun 284: 1104

    Article  CAS  PubMed  Google Scholar 

  37. Oshikawa K, Kuroiwa K, Tago K, Iwahana H, Yanagisawa K, Ohno S, Tominaga SI, Sugiyama Y (2001) Elevated soluble ST2 protein levels in sera of patients with asthma with an acute exacerbation. Am J Respir Crit Care Med 164: 277

    CAS  PubMed  Google Scholar 

  38. Tajima S, Oshikawa K, Tominaga S, Sugiyama Y (2003) The increase in serum soluble ST2 protein upon acute exacerbation of idiopathic pulmonary fibrosis. Chest 124: 1206

    Article  CAS  PubMed  Google Scholar 

  39. Weinberg EO, Shimpo M, De Keulenaer GW, MacGillivray C, Tominaga S, Solomon SD, Rouleau JL, Lee RT (2002) Expression and regulation of ST2, an interleukin-1 receptor family member, in cardiomyocytes and myocardial infarction. Circulation 106: 2961

    Article  CAS  PubMed  Google Scholar 

  40. Brint EK, Xu D, Liu H, Dunne A, McKenzie AN, O’Neill LA, Liew FJ (2004) ST2 is an inhibitor of interleukin 1 receptor and Toll-like receptor 4 signaling and maintains endotoxin tolerance. Nat Immunol 5: 373

    Article  CAS  PubMed  Google Scholar 

  41. Takeda K, Smyth MJ, Cretney E, Hayakawa Y, Kayagaki N, Yagita H, Okumura K (2002) Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development. J Exp Med 195: 161

    Article  CAS  PubMed  Google Scholar 

  42. Walczak H, Miller RE, Ariail K, Gliniak B, Griffith TS, Kubin M, Chin W, Jones J, Woodward A, Le T et al (1999) Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo. Nat Med 5: 157

    CAS  PubMed  Google Scholar 

  43. Diehl GE, Yue HH, Hsieh K, Kuang AA, Ho M, Morici LA, Lenz LL, Cado D, Riley LW, Winoto A (2004) TRAIL-R as a negative regulator of innate immune cell responses. Immunity 21: 877

    Article  CAS  PubMed  Google Scholar 

  44. Miyake K, Yamashita Y, Ogata M, Sudo T, Kimoto M (1995) RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family. J Immunol 154: 3333

    CAS  PubMed  Google Scholar 

  45. Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, Visintin A, Finberg RW, Tarakhovsky A, Vogel SN, Belkaid Y et al (2005) Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat Immunol 6: 571

    Article  CAS  PubMed  Google Scholar 

  46. Dunne A, O’Neill LA (2003) The interleukin-1 receptor/Toll-like receptor superfamily: signal transduction during inflammation and host defense. Sci STKE 2003:re3

    Google Scholar 

  47. Hardiman G, Jenkins NA, Copeland NG, Gilbert DJ, Garcia DK, Naylor SL, Kastelein RA, Bazan JF (1997) Genetic structure and chromosomal mapping of MyD88. Genomics 45: 332

    Article  CAS  PubMed  Google Scholar 

  48. Janssens S, Burns K, Tschopp J, Beyaert R (2002) Regulation of interleukin-1-and lipopolysaccharide-induced NF-kappaB activation by alternative splicing of MyD88. Curr Biol 12: 467

    Article  CAS  PubMed  Google Scholar 

  49. Burns K, Janssens S, Brissoni B, Olivos N, Beyaert R, Tschopp J (2003) Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4. J Exp Med 197: 263

    Article  PubMed  Google Scholar 

  50. Janssens S, Burns K, Vercammen E, Tschopp J, Beyaert R (2003) MyD88(S), a splice variant of MyD88, differentially modulates NF-kappaB-and AP-1-dependent gene expression. FEBS Lett 548: 103

    Article  CAS  PubMed  Google Scholar 

  51. Kubo M, Hanada T, Yoshimura A (2003) Suppressors of cytokine signaling and immunity. Nat Immunol 4: 1169

    Article  CAS  PubMed  Google Scholar 

  52. Johnston JA (2004) Are SOCS suppressors, regulators, and degraders? J Leukoc Biol 75: 743

    CAS  PubMed  Google Scholar 

  53. Crespo A, Filla MB, Russell SW, Murphy WJ (2000) Indirect induction of suppressor of cytokine signalling-1 in macrophages stimulated with bacterial lipopolysaccharide: partial role of autocrine/paracrine interferon-alpha/beta. Biochem J 349: 99

    Article  CAS  PubMed  Google Scholar 

  54. Dalpke AH, Opper S, Zimmermann S, Heeg K (2001) Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J Immunol 166: 7082

    CAS  PubMed  Google Scholar 

  55. Kinjyo I, Hanada T, Inagaki-Ohara K, Mori H, Aki D, Ohishi M, Yoshida H, Kubo M, Yoshimura A (2002) SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. Immunity 17: 583

    Article  CAS  PubMed  Google Scholar 

  56. Ryo A, Suizu F, Yoshida Y, Perrem K, Liou YC, Wulf G, Rottapel R, Yamaoka S, Lu KP (2003) Regulation of NF-kappaB signaling by Pin1-dependent prolyl isomerization and ubiquitin-mediated proteolysis of p65/RelA. Mol Cell 12: 1413

    Article  CAS  PubMed  Google Scholar 

  57. Baetz A, Frey M, Heeg K, Dalpke AH (2004) Suppressor of cytokine signaling (SOCS) proteins indirectly regulate toll-like receptor signaling in innate immune cells. J Biol Chem 279: 54708

    Article  CAS  PubMed  Google Scholar 

  58. Gingras S, Parganas E, de Pauw A, Ihle JN, Murray PJ (2004) Re-examination of the role of suppressor of cytokine signaling 1 (SOCS1) in the regulation of toll-like receptor signaling. J Biol Chem 279: 54702

    Article  CAS  PubMed  Google Scholar 

  59. Park SJ, Lee SC, Hong SH, Kim HM (2002) Degradation of IkappaBalpha in activated RAW264.7 cells is blocked by the phosphatidylinositol 3-kinase inhibitor LY294002. Cell Biol Toxicol 18: 121

    Google Scholar 

  60. Fukao T, Tanabe M, Terauchi Y, Ota T, Matsuda S, Asano T, Kadowaki T, Takeuchi T, Koyasu S (2002) PI3K-mediated negative feedback regulation of IL-12 production in DCs. Nat Immunol 3: 875

    CAS  PubMed  Google Scholar 

  61. Guha M, Mackman N (2002) The phosphatidylinositol 3-kinase-Akt pathway limits lipopolysaccharide activation of signaling pathways and expression of inflammatory mediators in human monocytic cells. J Biol Chem 277: 32124

    Article  CAS  PubMed  Google Scholar 

  62. Arbibe L, Mira JP, Teusch N, Kline L, Guha M, Mackman N, Godowski PJ, Ulevitch RJ, Knaus UG (2000) Toll-like receptor 2-mediated NF-kappa B activation requires a Rac1-dependent pathway. Nat Immunol 1: 533

    Article  CAS  PubMed  Google Scholar 

  63. Sizemore N, Leung S, Stark GR (1999) Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol 19: 4798

    CAS  PubMed  Google Scholar 

  64. Wesche H, Gao X, Li X, Kirschning CJ, Stark GR, Cao Z (1999) IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem 274: 19403

    CAS  PubMed  Google Scholar 

  65. Kobayashi K, Hernandez LD, Galan JE, Janeway CA Jr, Medzhitov R, Flavell RA (2002) IRAK-M is a negative regulator of Toll-like receptor signaling. Cell 110: 191

    Article  CAS  PubMed  Google Scholar 

  66. Escoll P, del Fresno C, Garcia L, Valles G, Lendinez MJ, Arnalich F, Lopez-Collazo E (2003) Rapid up-regulation of IRAK-M expression following a second endotoxin challenge in human monocytes and in monocytes isolated from septic patients. Biochem Biophys Res Commun 311: 465

    Article  CAS  PubMed  Google Scholar 

  67. Nakayama K, Okugawa S, Yanagimoto S, Kitazawa T, Tsukada K, Kawada M, Kimura S, Hirai K, Takagaki Y, Ota Y (2004) Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages. J Biol Chem 279: 6629

    Article  CAS  PubMed  Google Scholar 

  68. Burns K, Clatworthy J, Martin L, Martinon F, Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F (2000) Tollip, a new component of the IL-1RI pathway, links IRAK to the IL-1 receptor. Nat Cell Biol 2: 346

    CAS  PubMed  Google Scholar 

  69. Bulut Y, Faure E, Thomas L, Equils O, Arditi M (2001) Cooperation of Toll-like receptor 2 and 6 for cellular activation by soluble tuberculosis factor and Borrelia burgdorferi outer surface protein A lipoprotein: role of Toll-interacting protein and IL-1 receptor signaling molecules in Toll-like receptor 2 signaling. J Immunol 167: 987

    CAS  PubMed  Google Scholar 

  70. Zhang G, Ghosh S (2002) Negative regulation of toll-like receptor-mediated signaling by Tollip. J Biol Chem 277: 7059

    CAS  PubMed  Google Scholar 

  71. Melmed G, Thomas LS, Lee N, Tesfay SY, Lukasek K, Michelsen KS, Zhou Y, Hu B, Arditi M, Abreu MT (2003) Human intestinal epithelial cells are broadly unresponsive to Toll-like receptor 2-dependent bacterial ligands: implications for host-microbial interactions in the gut. J Immunol 170: 1406

    CAS  PubMed  Google Scholar 

  72. Li T, Hu J, Li L (2004) Characterization of Tollip protein upon Lipopolysaccharide challenge. Mol Immunol 41: 85

    CAS  PubMed  Google Scholar 

  73. Veillette A, Latour S, Davidson D (2002) Negative regulation of immunoreceptor signaling. Annu Rev Immunol 20: 669

    Article  CAS  PubMed  Google Scholar 

  74. Niki M, Di Cristofano A, Zhao M, Honda H, Hirai H, Van Aelst L, Cordon-Cardo C, Pandolfi PP (2004) Role of Dok-1 and Dok-2 in leukemia suppression. J Exp Med 200: 1689

    Article  CAS  PubMed  Google Scholar 

  75. Yamanashi Y, Tamura T, Kanamori T, Yamane H, Nariuchi H, Yamamoto T, Baltimore D (2000) Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling. Genes Dev 14: 11

    CAS  PubMed  Google Scholar 

  76. Jefferies CA, Doyle S, Brunner C, Dunne A, Brint E, Wietek C, Walch E, Wirth T, O’Neill LA (2003) Bruton’s tyrosine kinase is a Toll/interleukin-1 receptor domain-binding protein that participates in nuclear factor kappaB activation by Toll-like receptor 4. J Biol Chem 278: 26258

    Article  CAS  PubMed  Google Scholar 

  77. Shinohara H, Inoue A, Toyama-Sorimachi N, Nagai Y, Yasuda T, Suzuki H, Horai R, Iwakura Y, Yamamoto T, Karasuyama H et al (2005) Dok-1 and Dok-2 are negative regulators of lipopolysaccharide-induced signaling. J Exp Med 201: 333

    Article  CAS  PubMed  Google Scholar 

  78. Staub O (2004) Ubiquitylation and isgylation: overlapping enzymatic cascades do the job. Sci STKE 2004: pe43

    Google Scholar 

  79. Tanaka K, Kawakami T, Tateishi K, Yashiroda H, Chiba T (2001) Control of Ikappa-Balpha proteolysis by the ubiquitin-proteasome pathway. Biochimie 83: 351

    Article  CAS  PubMed  Google Scholar 

  80. Chuang TH, Ulevitch RJ (2004) Triad3A, an E3 ubiquitin-protein ligase regulating Tolllike receptors. Nat Immunol 5: 495

    CAS  PubMed  Google Scholar 

  81. Wang C, Deng L, Hong M, Akkaraju GR, Inoue J, Chen ZJ (2001) TAK1 is a ubiquitin-dependent kinase of MKK and IKK. Nature 412: 346

    CAS  PubMed  Google Scholar 

  82. Song HY, Rothe M, Goeddel DV (1996) The tumor necrosis factor-inducible zinc finger protein A20 interacts with TRAF1/TRAF2 and inhibits NF-kappaB activation. Proc Natl Acad Sci USA 93: 6721

    CAS  PubMed  Google Scholar 

  83. Jaattela M, Mouritzen H, Elling F, Bastholm L (1996) A20 zinc finger protein inhibits TNF and IL-1 signaling. J Immunol 156: 1166

    CAS  PubMed  Google Scholar 

  84. Cooper JT, Stroka DM, Brostjan C, Palmetshofer A, Bach FH, Ferran C (1996) A20 blocks endothelial cell activation through a NF-kappaB-dependent mechanism. J Biol Chem 271: 18068

    Article  CAS  PubMed  Google Scholar 

  85. Lee EG, Boone DL, Chai S, Libby SL, Chien M, Lodolce JP, Ma A (2000) Failure to regulate TNF-induced NF-kappaB and cell death responses in A20-deficient mice. Science 289: 2350

    CAS  PubMed  Google Scholar 

  86. Boone DL, Turer EE, Lee EG, Ahmad RC, Wheeler MT, Tsui C, Hurley P, Chien M, Chai S, Hitotsumatsu O, McNally E et al (2004) The ubiquitin-modifying enzyme A20 is required for termination of Toll-like receptor responses. Nat Immunol 5: 1052

    Article  CAS  PubMed  Google Scholar 

  87. Zetoune FS, Murthy AR, Shao Z, Hlaing T, Zeidler MG, Li Y, Vincenz C (2001) A20 inhibits NF-kappa B activation downstream of multiple Map3 kinases and interacts with the I kappa B signalosome. Cytokine 15: 282

    Article  CAS  PubMed  Google Scholar 

  88. Evans PC, Taylor ER, Coadwell J, Heyninck K, Beyaert R, Kilshaw PJ (2001) Isolation and characterization of two novel A20-like proteins. Biochem J 357: 617

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2006 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Brint, E. (2006). Endogenous regulation of toll-like receptor signalling. In: O’Neill, L.A., Brint, E. (eds) Toll-like Receptors in Inflammation. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7441-1_10

Download citation

Publish with us

Policies and ethics