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The role of complement in membranoproliferative glomerulonephritis

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Complement and Kidney Disease

Part of the book series: Progress in Inflammation Research ((PIR))

Conclusions

The alternative pathway of complement mediates immune defense and regulates tissue integrity. The recent characterization of the role of this complement activation pathway in distinct diseases, such as MPGN, atypical form of hemolytic uremic syndrome, age-related macular degeneration of the eye and in microbial immune evasion, highlight the importance of this branch of complement for the integrity of the human body. Proper regulation maintains tissue integrity, and improper regulation results in local defects which eventuate in severe diseases. The detailed understanding of the individual reactions and of the local role of the individual regulators defines how this part of complement maintains tissue integrity and how defects result in diseases. This understanding is essential to define proper tools and approaches for diagnosis and all kind of treatments which modulate the action of the complement system systemically and locally.

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Authors and Affiliations

  1. Department of Infection Biology, Leibniz Institute for Natural Products Research and Infection Biology, Hans Knoell Institute, Beutenbergstr. 11a, 07745, Jena, Germany

    Peter F. Zipfel & Stefan Heinen

  2. Department of Otolaryngology, The University of Iowa, 200 Hawkins Drive, 21151 PFP, Iowa City, IA, 52242, USA

    Richard J.H. Smith

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  1. Peter F. Zipfel
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  1. Department of Infection Biology, Leibniz Institute for Natural Product Research and Infection Biology, Hans Knoell Institute, Beutenbergstr. 11a, D-07745, Jena, Germany

    Peter F. Zipfel

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Zipfel, P.F., Smith, R.J., Heinen, S. (2006). The role of complement in membranoproliferative glomerulonephritis. In: Zipfel, P.F. (eds) Complement and Kidney Disease. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7428-4_11

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