Skip to main content

Evolutionary perspective on the NPY-PYY-PP peptides and their receptors

  • Chapter
  • 427 Accesses

Part of the book series: Progress in Inflammation Research ((PIR))

This is a preview of subscription content, log in via an institution.

Buying options

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Tatemoto K (1982) Neuropeptide Y: Complete amino acid sequence of the brain peptide. Proc Natl Acad Sci USA 79: 5485–5489

    PubMed  CAS  Google Scholar 

  2. Tatemoto K (1982) Isolation and characterization of peptide YY (PYY), a candidate gut hormone that inhibits pancreatic exocrine secretion. Proc Natl Acad Sci USA 79: 2514–2518

    PubMed  CAS  Google Scholar 

  3. Larhammar D, Blomqvist AG, Söderberg C (1993) Evolution of neuropeptide Y and its related peptides. Comp Biochem Physiol 106C: 743–752

    CAS  Google Scholar 

  4. Larhammar D (1996) Structural diversity of receptors for neuropeptide Y, peptide YY and pancreatic polypeptide. Regul Pept 65: 165–174

    Article  PubMed  CAS  Google Scholar 

  5. Cerdá-Reverter JM, Larhammar D (2000) Neuropeptide Y family of peptides: structure, anatomical expression, function, and molecular evolution. Biochem Cell Biol 78: 371–392

    PubMed  Google Scholar 

  6. Pedrazzini T, Pralong F, Grouzmann E (2003) Neuropeptide Y: the universal soldier. Cell Mol Life Sci 60: 350–377

    Article  PubMed  CAS  Google Scholar 

  7. Fujimiya M, Inui A (2000) Peptidergic regulation of gastrointestinal motility in rodents. Peptides 21: 1565–1582

    Article  PubMed  CAS  Google Scholar 

  8. Naruse S, Kitagawa M, Ishiguro H, Hayakawa T (2002) Feedback regulation of pancreatic secretion by peptide YY. Peptides 23: 359–365

    Article  PubMed  CAS  Google Scholar 

  9. Batterham RL, Cowley MA, Small CJ, Herzog H, Cohen MA, Dakin CL, Wren AM, Brynes AE, Low MJ, Ghatei MA et al (2002) Gut hormone PYY(3-36) physiologically inhibits food intake. Nature 418: 650–654

    Article  PubMed  CAS  Google Scholar 

  10. Kimmel JR, Hayden LJ, Pollock HG (1975) Isolation and characterization of a new pancreatic polypeptide hormone. J Biol Chem 250: 9369–9374

    PubMed  CAS  Google Scholar 

  11. Hort Y, Baker E, Sutherland GR, Shine J, Herzog H (1995) Gene duplication of the human peptide YY gene (PYY) generated the pancreatic polypeptide gene (PPY) on chromosome 17q21.1. Genomics 26: 77–83

    Article  PubMed  CAS  Google Scholar 

  12. Hazelwood RL (1993) The pancreatic polypeptide (PP-fold) family: Gastrointestinal, vascular, and feeding behavioral implications. Proc Soc Expl Biol Med 202: 44–63

    CAS  Google Scholar 

  13. Batterham RL, Le Roux CW, Cohen MA, Park AJ, Ellis SM, Patterson M, Frost GS, Ghatei MA, Bloom SR (2003) Pancreatic polypeptide reduces appetite and food intake in humans. J Clin Endocrinol Metab 88: 3989–3992

    Article  PubMed  CAS  Google Scholar 

  14. Blomqvist AG, Söderberg C, Lundell I, Milner RJ, Larhammar D (1992) Strong evolutionary conservation of neuropeptide Y: Sequences of chicken, goldfish, and Torpedo marmorata DNA clones. Proc Natl Acad Sci USA 89: 2350–2354

    PubMed  CAS  Google Scholar 

  15. Söderberg C, Pieribone VA, Dahlstrand J, Brodin L, Larhammar D (1994) Neuropeptide role of both peptide YY and neuropeptide Y in vertebrates suggested by abundant expression of their mRNAs in a cyclostome brain. J Neurosci Res 37: 633–640

    PubMed  Google Scholar 

  16. Söderberg C, Wraith A, Ringvall M, Yan Y-L, Postlethwait J, Brodin L, Larhammar D (2000) Zebrafish genes for neuropeptide Y and peptide YY reveal origin by chromosome duplication from an ancestral gene linked to the homeobox cluster. J Neurochem 75: 908–918

    PubMed  Google Scholar 

  17. Cerdá-Reverter JM, Martínez-Rodrïguez G, Zanuy S, Carrillo M, Larhammar D (2000) Molecular evolution of the neuropeptide Y (NPY) family of peptides: cloning of NPY-related peptides from the sea bass (Dicentrarchus labrax). Regul Peptides 95: 25–34

    Google Scholar 

  18. Larhammar D (1996) Evolution of neuropeptide Y, peptide YY, and pancreatic polypeptide. Regul Peptides 62: 1–11

    CAS  Google Scholar 

  19. Force A, Lynch M, Pickett FB, Amores A, Yan Y, Postlethwait J (1999) Preservation of duplicate genes by complementary, degenerative mutations. Genetics 151: 1531–1545

    PubMed  CAS  Google Scholar 

  20. Eva C, Keinänen K, Monyer H, Seeburg P, Sprengel R (1990) Molecular cloning of a novel G protein-couple receptor that may belong to the neuropeptide receptor family. FEBS Lett 271: 81–84

    Article  PubMed  CAS  Google Scholar 

  21. Krause J, Eva C, Seeburg PH, Sprengel R (1992) Neuropeptide Y1 subtype pharmacology of a recombinantly expressed neuropeptide receptor. Mol Pharmacol 41: 817–821

    PubMed  CAS  Google Scholar 

  22. Herzog H, Hort YJ, Ball HJ, Hayes G, Shine J, Selbie LA (1992) Cloned human neuropeptide Y receptor couples to two different second messenger systems. Proc Natl Acad Sci USA 89: 5794–5798

    PubMed  CAS  Google Scholar 

  23. Larhammar D, Blomqvist AG, Yee F, Jazin E, Yoo H, Wahlestedt C (1992) Cloning and functional expression of a human neuropeptide Y/peptide YY receptor of the Y1 type. J Biol Chem 267: 10935–10938

    PubMed  CAS  Google Scholar 

  24. Larhammar D, Wraith A, Berglund MM, Holmberg SKS, Lundell I (2001) Origins of the multiple NPY-family receptors in mammals. Peptides 22: 295–307

    Article  PubMed  CAS  Google Scholar 

  25. Dores RM, Rubin DA, Quinn TW (1996) Is it possible to construct phylogenetic trees using polypeptide hormone sequences? Gen Comp Endocrinol 103: 1–12

    Article  PubMed  CAS  Google Scholar 

  26. Tensen CP, Cox KJA, Burke JF, Leurs R, van der Schors RC, Geraerts WPM, Vreugdenhil E, van Heerikhuizen H (1998) Molecular cloning and characterization of an invertebrate homologue of a neuropeptide Y receptor. Eur J Neurosci 10: 3409–3416

    Article  PubMed  CAS  Google Scholar 

  27. Hoek RM, van Kesteren RE, Smit AB, de Jong-Brink M, Geraerts WP (1997) Altered gene expression in the host brain caused by a trematode parasite: neuropeptide genes are preferentially affected during parasitosis. Proc Natl Acad Sci USA 94: 14072–14076

    Article  PubMed  CAS  Google Scholar 

  28. Garczynski SF, Brown MR, Shen P, Murray TF, Crim JW (2002) Characterization of a functional neuropeptide F receptor from Drosophila melanogaster. Peptides 23: 773–780

    Article  PubMed  CAS  Google Scholar 

  29. Brown MR, Crim JW, Arata RC, Cai HN, Chun C, Shen P (1999) Identification of a Drosophila brain-gut peptide related to the neuropeptide Y family. Peptides 20: 1035–1042

    Article  PubMed  CAS  Google Scholar 

  30. Wu Q, Wen T, Lee G, Park JH, Cai HN, Shen P (2003) Developmental control of foraging and social behavior by the Drosophila neuropeptide Y-like system. Neuron 39: 147–161

    Article  PubMed  CAS  Google Scholar 

  31. Stanek DM, Pohl J, Crim JW, Brown MR (2002) Neuropeptide F and its expression in the yellow fever mosquito, Aedes aegypti. Peptides 23: 1367–1378

    Article  PubMed  CAS  Google Scholar 

  32. Riehle MA, Garczynski SF, Crim JW, Hill CA, Brown MR (2002) Neuropeptides and peptide hormones in Anopheles gambiae. Science 298: 172–175

    Article  PubMed  CAS  Google Scholar 

  33. Xia Q, Zhou Z, Lu C, Cheng D, Dai F, Li B, Zhao P, Zha X, Cheng T, Chai C et al (2004) A draft sequence for the genome of the domesticated silkworm (Bombyx mori). Science 306: 1937–1940

    PubMed  Google Scholar 

  34. Garczynski SF, Crim JW, Brown MR (2005) Characterization of neuropeptide F and its receptor from the African malaria mosquite, Anopheles gambiae. Peptides 26: 99–107

    Article  PubMed  CAS  Google Scholar 

  35. Li X-J, Wu Y-N, North A, Forte M (1992) Cloning, functional expression, and developmental regulation of a neuropeptide Y receptor from Drosophila melanogaster. J Biol Chem 267: 9–12

    PubMed  CAS  Google Scholar 

  36. Mertens I, Meeusen T, Huybrechts R, De Loof A, Schoofs L (2002) Characterization of the short neuropeptide F receptor from Drosophila melanogaster. Biochem Biophys Res Commun 297: 1140–1148

    Article  PubMed  CAS  Google Scholar 

  37. Feng G, Reale V, Chatwin H, Kennedy K, Venard R, Ericsson C, Yu K, Evans P D, Hall L M (2003) Functional characterization of a neuropeptide F-like receptor from Drosophila melanogaster. Eur J Neurosci 18: 227–238

    Article  PubMed  Google Scholar 

  38. de Bono M, Bargmann CI (1998) Natural variation in a neuropeptide Y receptor homolog modifies social behavior and food response in C. elegans. Cell 94: 679–689

    PubMed  Google Scholar 

  39. Kubiak TM, Larsen MJ, Nulf SC, Zantello MR, Burton KJ, Bowman JW, Modric T, Lowery DE (2003) Differential activation of “social” and “solitary” variants of the C. elegans GPCR NPR-1 by its cognate ligand AF9. J Biol Chem 278: 33724–33729

    PubMed  CAS  Google Scholar 

  40. Conlon JM (2002) The origin and evolution of peptide YY (PYY) and pancreatic polypeptide (PP). Peptides 23: 269–278

    PubMed  Google Scholar 

  41. Larhammar D, Fredriksson R, Larson ET, Salaneck E (2004) In: Michel MC (ed): Neuropeptide Y and Related Peptides, Springer-Verlag, Berlin-Heidelberg pp 75–100

    Google Scholar 

  42. Conlon JM, Bjørnholm B, Jørgensen FS, Youson JH, Schwartz TW (1991) Primary structure and conformational analysis of peptide methionine-tyrosine, a peptide related to neuropeptide Y and peptide YY isolated from lamprey intestine. Eur J Biochem 199: 293–298

    Article  PubMed  CAS  Google Scholar 

  43. Wang Y, Nielsen PF, Youson JH, Potter IC, Lance VA, Conlon JM (1999) Molecular evolution of peptide tyrosine-tyrosine: primary structure of PYY from the lampreys Geotria australis and Lampetra fluviatilis, bichir, python and desert tortoise. Regulatory Peptides 79: 103–108

    PubMed  CAS  Google Scholar 

  44. Montpetit CJ, Chatalov V, Yuk J, Rasaratnam I, Youson JH (2005) Expression of neuropeptide Y family peptides in the brain and gut during stages of the life cycle of a parasitic lamprey (Petromyzon marinus) and a nonparasitic lamprey (Ichthyomyzon gagei). In: Vaudry H, Roubos E, Schoofs L, Flik G, Larhammar D (eds): Trends in Comparative Endocrinology and Neurobiology. Ann NY Acad Sci 1040: 140–149

    Google Scholar 

  45. Baker E, Hort YJ, Ball H, Sutherland GR, Shine J, Herzog H (1995) Assignment of the human neuropeptide Y gene to chromosome 7p15.1 by nonisotopic in situ hybridization. Genomics 26: 163–164

    Article  PubMed  CAS  Google Scholar 

  46. Coulier F, Popovici C, Villet R, Birnbaum D (2000) MetaHOX gene clusters. J Exp Zool 288: 345–351

    Article  PubMed  CAS  Google Scholar 

  47. Popovici C, Leveugle M, Birnbaum D, Coulier F (2001) Homeobox gene clusters and the human paralogy map. FEBS Lett 491: 237–242

    Article  PubMed  CAS  Google Scholar 

  48. Lundin LG, Hallböök F, Larhammar D (2003) Numerous groups of chromosomal regional paralogies strongly indicate two genome doublings at the root of the vertebrates. J Struct Funct Genomics 3: 53–63

    Article  PubMed  CAS  Google Scholar 

  49. Garcia-Fernàndez J, Holland PWH (1994) Archetypal organization of the amphioxus Hox gene cluster. Nature 370: 563–566

    PubMed  Google Scholar 

  50. Holland PWH, Garcia-Fernàndez J, Williams NA, Sidow A (1994) Gene duplications and the origins of vertebrate development. Dev Suppl 125–133

    Google Scholar 

  51. Shimeld MS, Holland PWH (2000) Vertebrate innovations. Proc Natl Acad Sci USA 97: 4449–4452

    Article  PubMed  CAS  Google Scholar 

  52. Postlethwait J, Amores A, Cresko W, Singer A, Yan YL (2004) Subfunction partitioning, the teleost radiation and the annotation of the human genome. Trends Genet 20: 481–490

    Article  PubMed  CAS  Google Scholar 

  53. Taylor JS, Braasch I, Frickey T, Meyer A, Van de Peer Y (2003) Genome duplication, a trait shared by 22,000 species of ray-finned fish. Genome Res 13: 382–390

    Article  PubMed  CAS  Google Scholar 

  54. Jaillon O, Aury JM, Brunet F, Petit JL, Stange-Thomann N, Mauceli E, Bouneau L, Fischer C, Ozouf-Costaz C, Bernot A et al (2004) Genome duplication in the teleost fish Tetraodon nigroviridis reveals the early vertebrate proto-karyotype. Nature 431: 946–957

    Article  PubMed  Google Scholar 

  55. Powers TP, Amemiya CT (2004) Evolutionary plasticity of vertebrate Hox genes. Curr Genomics 5: 459–472

    CAS  Google Scholar 

  56. Hoegg S, Meyer A (2005) Hox clusters as models for vertebrate genome evolution. Trends in Genetics 21: 421–424

    Article  PubMed  CAS  Google Scholar 

  57. Sundström G, Larsson TA, Brenner S, Venkatesh B, Larhammar D (2005) Ray-fin fish tetraploidization gave rise to pufferfish duplicates of NPY and PYY, but zebrafish NPY duplicate was lost. In: Vaudry H, Roubos E, Schoofs L, Flik G, Larhammar D (eds): Trends in Comparative Endocrinology and Neurobiology. Ann NY Acad Sci 1040: 476–478

    Google Scholar 

  58. Pieribone VA, Brodin L, Friberg K, Dahlstrand J, Söderberg C, Larhammar D, Hökfelt T (1992) Differential expression of mRNAs for neuropeptide Y-related peptides in rat nervous tissues: possible evolutionary conservation. J Neuroscience 12: 3361–3371

    CAS  Google Scholar 

  59. Söderberg C (1996) Molecular evolution of the neuropeptide Y family peptides. Uppsala University, Uppsala, Sweden

    Google Scholar 

  60. Ekblad E, Sundler F (2002) Distribution of pancreatic polypeptide and peptide YY. Peptides 23: 251–261

    Article  PubMed  CAS  Google Scholar 

  61. Michel MC, Beck-Sickinger A, Cox H, Doods HN, Herzog H, Larhammar D, Quirion R, Schwartz T, Westfall T (1998) XVI. International Union of Pharmacology recommendations for the nomenclature of neuropeptide Y, peptide YY and pancreatic polypeptide receptors. Pharmacol Rev 50: 143–150

    PubMed  CAS  Google Scholar 

  62. Rimland J, Xin W, Sweetnam P, Saijoh K, Nestler EJ, Duman RS (1991) Sequence and expression of a neuropeptide Y receptor cDNA. Mol Pharmacol 40: 869–875

    PubMed  CAS  Google Scholar 

  63. Herzog H, Hort YJ, Shine J, Selbie LA (1993) Molecular cloning, characterization and localization of the human homolog to the reported bovine NPY Y3 receptor: Lack of NPY binding and activation. DNA Cell Biol 12: 465–471

    PubMed  CAS  Google Scholar 

  64. Jazin EE, Yoo H, Blomqvist AG, Yee F, Weng G, Walker MW, Salon J, Larhammar D, Wahlestedt C (1993) A proposed bovine neuropeptide Y (NPY) receptor, or its human homologue, confers neither NPY binding sites nor NPY responsiveness on transfected cells. Regul Peptides 47: 247–258

    CAS  Google Scholar 

  65. Starbäck P, Wraith A, Eriksson H, Larhammar D (2000) Neuropeptide Y receptor gene y6: multiple deaths or resurrection? Biochem Biophys Res Comm 277: 264–269

    PubMed  Google Scholar 

  66. Larhammar D, Fredriksson R, Salaneck E, Larsson TA, Holmberg SKS, Lundell I, Larson ET (2002) Evolution of vertrebrate neuropeptide Y receptors. In: Keller R, Dircksen H, Sedlmeier D, Vaudry H (eds): Proceedings of the 21st Conference of European Comparative Endocrinologists. Monduzzi Editore, Bologna 17–22

    Google Scholar 

  67. Larhammar D, Salaneck E (2004) Molecular evolution of NPY receptor subtypes. Neuropeptides 38: 141–151

    Article  PubMed  CAS  Google Scholar 

  68. Wraith A, Törnsten A, Chardon P, Harbitz I, Chowdhary BP, Andersson L, Lundin LG, Larhammar D (2000) Evolution of the neuropeptide Y receptor family: gene and chromosome duplications deduced from the cloning of the five receptor subtype genes in pig. Genome Res 10: 302–310

    Article  PubMed  CAS  Google Scholar 

  69. Sidow A (1996) Gen(om)e duplications in the evolution of early vertebrates. Curr Opin Genetics Devel 6: 715–722

    CAS  Google Scholar 

  70. Gregor P, Feng Y, DeCarr LB, Cornfield LJ, McCaleb ML (1996) Molecular characterization of a second mouse pancreatic polypeptide receptor and its inactivated human homologue. J Biol Chem 271: 27776–27781

    PubMed  CAS  Google Scholar 

  71. Matsumoto M, Nomura T, Momoses K, Ikeda Y, Kondou Y, Akiho H, Togami J, Kimura Y, Okada M, Yamaguchi T (1996) Inactivation of a novel neuropeptide Y/peptide YY receptor gene in primate species. J Biol Chem 271: 27217–27220

    PubMed  CAS  Google Scholar 

  72. Rose PM, Lynch JS, Frazier ST, Fisher SM, Chung W, Battaglino P, Fathi Z, Leibel R, Prabhavathi F (1997) Molecular genetic analysis of a human neuropeptide Y receptor. The human homolog of the murine “Y5” receptor may be a pseudogene. J Biol Chem 272: 3622–3627

    PubMed  CAS  Google Scholar 

  73. Burkhoff A, Linemeyer DL, Salon JA (1998) Distribution of a novel hypothalamic neuropeptide Y receptor gene and its absence in rat. Mol Brain Res 53: 311–316

    Article  PubMed  CAS  Google Scholar 

  74. Nakamura M, Yokoyama M, Watanabe H, Matsumoto T (1997) Molecular cloning, organization and localization of the gene for the mouse neuropeptide Y-Y5 receptor. Biochim Biophys Acta 1328: 83–89

    PubMed  CAS  Google Scholar 

  75. Borowsky B, Walker MW, Bard J, Weinshank RL, Laz TM, Vaysse P, Branchek TA, Gerald C (1998) Molecular biology and pharmacology of multiple NPY Y5 receptor species homologs. Regul Pept 75-76: 45–53

    Article  PubMed  CAS  Google Scholar 

  76. Wraith A (1999) Molecular evolution of the neuropeptide Y receptor family. Insights from mammals and fish. Uppsala University, Uppsala, Sweden

    Google Scholar 

  77. Berglund MM, Hipskind PA, Gehlert DR (2003) Recent developments in our understanding of the physiological role of PP-fold peptide receptor subtypes. Exp Biol Med (Maywood) 228: 217–244

    CAS  Google Scholar 

  78. Pedrazzini T, Seydoux J, Kunstner P, Aubert J-F, Grouzmann E, Beermann F, Brunner HR (1998) Cardiovascular response, feeding behavior and locomotor activity in mice lacking the NPY Y1 receptor. Nature Med 4: 722–726

    PubMed  CAS  Google Scholar 

  79. Campbell RE, Ffrench-Mullen JM, Cowley MA, Smith MS, Grove KL (2001) Hypothalamic circuitry of neuropeptide Y regulation of neuroendocrine function and food intake via the Y5 receptor subtype. Neuroendocrinology 74: 106–119

    Article  PubMed  CAS  Google Scholar 

  80. Wolak ML, DeJoseph MR, Cator AD, Mokashi AS, Brownfield MS, Urban JH (2003) Comparative distribution of neuropeptide Y Y1 and Y5 receptors in the rat brain by using immunohistochemistry. J Comp Neurol 464: 285–311

    Article  PubMed  CAS  Google Scholar 

  81. Kopp J, Xu ZQ, Zhang X, Pedrazzini T, Herzog H, Kresse A, Wong H, Walsh JH, Hokfelt T (2002) Expression of the neuropeptide Y Y1 receptor in the CNS of rat and of wild-type and Y1 receptor knock-out mice. Focus on immunohistochemical localization. Neuroscience 111: 443–532

    Article  PubMed  CAS  Google Scholar 

  82. Matsuda H, Brumovsky PR, Kopp J, Pedrazzini T, Hokfelt T (2002) Distribution of neuropeptide Y Y1 receptors in rodent peripheral tissues. J Comp Neurol 449: 390–404

    Article  PubMed  CAS  Google Scholar 

  83. Parker RM, Herzog H (1999) Regional distribution of Y-receptor subtype mRNAs in rat brain. Eur J Neurosci 11: 1431–1448

    PubMed  CAS  Google Scholar 

  84. Herzog H, Darby K, Ball H, Hort Y, Beck-Sickinger A, Shine J (1997) Overlapping gene structure of the human neuropeptide Y receptor subtypes Y1 and Y5 suggests coordinate transcriptional regulation. Genomics 41: 315–319

    Article  PubMed  CAS  Google Scholar 

  85. Batterham RL, Cohen MA, Ellis SM, Le Roux CW, Withers DJ, Frost GS, Ghatei MA, Bloom SR (2003) Inhibition of food intake in obese subjects by peptide YY3-36. N Engl J Med 349: 941–948

    Article  PubMed  CAS  Google Scholar 

  86. Zukowska-Grojec Z, Karwatowska-Prokopczuk E, Fisher TA, Ji H (1998) Mechanisms of vascular growth-promoting effects of neuropeptide Y: role of its inducible receptors. Regul Pept 75-76: 231–238

    Article  PubMed  CAS  Google Scholar 

  87. Golombek DA, Biello SM, Rendon RA, Harrington ME (1996) Neuropeptide Y phase shifts the circadian clock in vitro via a Y2 receptor. Neuroreport 7: 1315–1319

    PubMed  CAS  Google Scholar 

  88. Huhman KL, Gillespie CF, Marvel CL, Albers HE (1996) Neuropeptide Y phase shifts circadian rhythms in vivo via a Y2 receptor. Neuroreport 7: 1249–1252

    PubMed  CAS  Google Scholar 

  89. Salaneck E, Holmberg SK, Berglund MM, Boswell T, Larhammar D (2000) Chicken neuropeptide Y receptor Y2: structural and pharmacological differences to mammalian Y2. FEBS Lett 484: 229–234

    Article  PubMed  CAS  Google Scholar 

  90. Holmberg SK, Mikko S, Boswell T, Zoorob R, Larhammar D (2002) Pharmacological characterization of cloned chicken neuropeptide Y receptors Y1 and Y5. J Neurochem 81: 462–471

    Article  PubMed  CAS  Google Scholar 

  91. Lundell I, Boswell T, Larhammar D (2002) Chicken neuropeptide Y-family receptor Y4: a receptor with equal affinity for pancreatic polypeptide, neuropeptide Y and peptide YY. J Mol Endocrinol 28: 225–235

    Article  PubMed  CAS  Google Scholar 

  92. Lundell I, Berglund MM, Starbäck P, Salaneck E, Gehlert DR, Larhammar D (1997) Cloning and characterization of a novel neuropeptide Y receptor subtype in the zebrafish. DNA Cell Biol 16: 1357–1363

    Article  PubMed  CAS  Google Scholar 

  93. Blomqvist AG, Roubos EW, Larhammar D, Martens GJ (1995) Cloning and sequence analysis of a neuropeptide Y/peptide YY receptor Y1 cDNA from Xenopus laevis. Biochim Biophys Acta 1261: 439–441

    PubMed  Google Scholar 

  94. Fredriksson R, Larson ET, Yan Y-L, Postlethwait JH, Larhammar D (2003) Novel neuropeptide Y Y2-like receptor subtype in zebrafish and frogs supports early vertebrate chromosome duplications. J Mol Evol 58: 106–114

    Google Scholar 

  95. Ringvall M, Berglund MM, Larhammar D (1997) Multiplicity of neuropeptide Y receptors: cloning of a third distinct subtype in the zebrafish. Biochem Biophys Res Comm 241: 749–755

    Article  PubMed  CAS  Google Scholar 

  96. Starbäck P, Lundell I, Fredriksson R, Berglund MM, Yan Y-L, Wraith A, Söderberg C, Postlethwait JH, Larhammar D (1999) Neuropeptide Y receptor subtype with unique properties cloned in the zebrafish; the zYa receptor. Mol Brain Res 70: 242–252

    PubMed  Google Scholar 

  97. Salaneck E, Ardell D, Larson ET, Larhammar D (2003) Three neuropeptide Y receptors in the spiny dogfish, Squalus acanthias, support chromosome doublings in early vertebrate evolution. Mol Biol Evol 20: 1271–1280

    PubMed  CAS  Google Scholar 

  98. Larsson TA, Olsson F, Sundström G, Brenner S, Venkatesh B, Larhammar D (2005) Pufferfish and zebrafish have five distinct NPY receptor subtypes, but have lost appetite receptors Y1 and Y5. Ann NY Acad Sci 1040: 375–377

    PubMed  CAS  Google Scholar 

  99. Salaneck E, Larson ET, Larsson TA, Larhammar D (2005) Effects of a teleost tetraploidization on neuropeptide Y receptor gene repertoire in ray-finned fishes. Ann NY Acad Sci 1040: 457–459

    PubMed  CAS  Google Scholar 

  100. Salaneck E, Fredriksson R, Larson ET, Conlon JM, Larhammar D (2001) A neuropeptide Y receptor Y1-subfamily gene from an agnathan, the European river lamprey. A potential ancestral gene. Eur J Biochem 268: 6146–6154

    Article  PubMed  CAS  Google Scholar 

  101. Narnaware YK, Peter RE (2001) Neuropeptide Y stimulates food consumption through multiple receptors in goldfish. Physiol Behav 74: 185–190

    Article  PubMed  CAS  Google Scholar 

  102. Silverstein JT, Breininger J, Baskin DG, Plisetskaya EM (1998) Neuropeptide Y-like gene expression in the salmon brain increases with fasting. Gen Comp Endocrinol 110: 157–165

    Article  PubMed  CAS  Google Scholar 

  103. Larsen P, Tang-Christensen M, Stidsen C, Madsen K, Smith M, Cameron J (1999) Activation of central neuropeptide Y Y1 receptors potently stimulates food intake in male rhesus monkeys. J Clin Endocrinol Metab 84: 3781–3791

    Article  PubMed  CAS  Google Scholar 

  104. Parrott RF, Heavens RP, Baldwin BA (1986) Stimulation of feeding in the satiated pig by intracerebroventricular injection of neuropeptide Y. Physiol Behav 36: 523–525

    Article  PubMed  CAS  Google Scholar 

  105. Miner JL, Della-Fera MA, Paterson JA, Baile CA (1989) Lateral cerebroventricular injection of neuropeptide Y stimulates feeding in sheep. Am J Physiol 257: R383–R387

    PubMed  CAS  Google Scholar 

  106. Pau MY, Pau KY, Spies HG (1988) Characterization of central actions of neuropeptide Y on food and water intake in rabbits. Physiol Behav 44: 797–802

    Article  PubMed  CAS  Google Scholar 

  107. Kulkosky PJ, Glazner GW, Moore HD, Low CA, Woods SC (1988) Neuropeptide Y: behavioral effects in the golden hamster. Peptides 9: 1389–1393

    Article  PubMed  CAS  Google Scholar 

  108. Lecklin A, Lundell I, Paananen L, Wikberg JE, Männistö PT, Larhammar D (2002) Receptor subtypes Y1 and Y5 mediate neuropeptide Y induced feeding in the guineapig. Br J Pharmacol 135: 2029–2037

    Article  PubMed  CAS  Google Scholar 

  109. Lecklin A, Lundell I, Salmela S, Beck-Sickinger AG, Larhammar D (2003) Agonists for neuropeptide Y receptors Y1 and Y5 stimulate different phases of feeding in guinea pigs. Br J Pharmacol 139: 1433–1440

    Article  PubMed  CAS  Google Scholar 

  110. Boswell T, Richardson RD, Schwartz MW, D’Alessio DA, Woods SC, Sipols AJ, Baskin D G, Kenagy GJ (1993) NPY and galanin in a hibernator: hypothalamic gene expression and effects on feeding. Brain Res Bull 32: 379–384

    Article  PubMed  CAS  Google Scholar 

  111. Kuenzel WJ, Douglass LW, Davison BA (1987) Robust feeding following central administration of neuropeptide Y or peptide YY in chicks, Gallus domesticus. Peptides 8: 823–828

    Article  PubMed  CAS  Google Scholar 

  112. Richardson RD, Boswell T, Raffety BD, Seeley RJ, Wingfield JC, Woods SC (1995) NPY increases food intake in white-crowned sparrows: effect in short and long photoperiods. Am J Physiol 268: R1418–R1422

    PubMed  CAS  Google Scholar 

  113. Morris YA, Crews D (1990) The effects of exogenous neuropeptide Y on feeding and sexual behavior in the red-sided garter snake (Thamnophis sirtalis parietalis). Brain Res 530: 339–341

    Article  PubMed  CAS  Google Scholar 

  114. Crespi EJ, Vaudry H, Denver RJ (2004) Roles of corticotropin-releasing factor, neuropeptide Y and corticosterone in the regulation of food intake in Xenopus laevis. J Neuroendocrinol 16: 279–288

    Article  PubMed  CAS  Google Scholar 

  115. Volkoff H, Peter RE (2001) Interactions between orexin A, NPY and galanin in the control of food intake of the goldfish, Carassius auratus. Regul Pept 101: 59–72

    Article  PubMed  CAS  Google Scholar 

  116. Volkoff H, Canosa LF, Unniappan S, Cerda-Reverter JM, Bernier NJ, Kelly SP, Peter RE (2005) Neuropeptides and the control of food intake in fish. Gen Comp Endocrinol 142: 3–19

    Article  PubMed  CAS  Google Scholar 

  117. Inui A, Okita M, Nakajima M, Inoue T, Sakatani N, Oya M, Morioka H, Okimura Y, Chihara K, Baba S (1991) Neuropeptide regulation of feeding in dogs. Am J Physiol 261: R588–R594

    PubMed  CAS  Google Scholar 

  118. Bjenning C, Holmgren S, Farrell AP (1993) Neuropeptide Y potentiates contractile response to norepinephrine in skate coronary artery. Am J Physiol 265: H661–H665

    PubMed  CAS  Google Scholar 

  119. Bjenning C, Hazon N, Balasubramaniam A, Holmgren S, Conlon JM (1993) Distribution and activity of dogfish NPY and peptide YY in the cardiovascular system of the common dogfish. Am J Physiol 264: R1119–R1124

    PubMed  CAS  Google Scholar 

  120. Xiang H (1994) Comparative aspects of the role of neuropeptide Y in the regulation of the vertebrate heart. Cardiosci 5: 209–213

    CAS  Google Scholar 

  121. Preston E, Jonsson AC, McManus CD, Conlon JM, Courtice GP (1998) Comparative vascular responses in elasmobranchs to different structures of neuropeptide Y and peptide YY. Regul Pept 78: 57–67

    Article  PubMed  CAS  Google Scholar 

  122. Uesaka T (1996) Synergistic action of neuropeptide Y and adrenaline in the eel atrium. J Exp Biol 199: 1873–1880

    PubMed  CAS  Google Scholar 

  123. Shahbazi F, Holmgren S, Larhammar D, Jensen J (2002) Neuropeptide Y effects on vasorelaxation and intestinal contraction in the Atlantic cod Gadus morhua. Am J Physiol Regul Integr Comp Physiol 282: R1414–R1421

    PubMed  CAS  Google Scholar 

  124. Chartrel N, Conlon JM, Danger J-M, Fournier A, Tonon N-C, Vaudry H (1991) Characterization of melanotropin-release-inhibiting factor (melanostatin) from frog brain: Homology with human neuropeptide Y. Proc Natl Acad Sci USA 88: 3862–3866

    PubMed  CAS  Google Scholar 

  125. Mor A, Chartrel N, Vaudry H, Nicolas P (1994) Skin peptide tyrosine-tyrosine, a member of the pancreatic polypeptide family: Isolation, structure, synthesis, and endocrine activity. Proc Natl Acad Sci USA 91: 10295–10299

    PubMed  CAS  Google Scholar 

  126. Galas L, Tonon MC, Beaujean D, Fredriksson R, Larhammar D, Lihrmann I, Jegou S, Fournier A, Chartrel N, Vaudry H (2002) Neuropeptide Y inhibits spontaneous alphamelanocyte-stimulating hormone (alpha-MSH) release via a Y(5) receptor and suppresses thyrotropin-releasing hormone-induced alpha-MSH secretion via a Y(1) receptor in frog melanotrope cells. Endocrinology 143: 1686–1694

    Article  PubMed  CAS  Google Scholar 

  127. Zukowska Z, Pons J, Lee EW, Li L (2003) Neuropeptide Y: a new mediator linking sympathetic nerves, blood vessels and immune system? Can J Physiol Pharmacol 81: 89–94

    Article  PubMed  CAS  Google Scholar 

  128. Bedoui S, Miyake S, Straub RH, von Horsten S, Yamamura T (2004) More sympathy for autoimmunity with neuropeptide Y? Trends Immunol 25: 508–512

    Article  PubMed  CAS  Google Scholar 

  129. Ericsson A, Larhammar D, McIntyre KR, Persson H (1987) A molecular genetic approach to the identification of genes expressed predominantly in the neuroendocrine and immune systems. Immunol Rev 100: 261–277

    PubMed  CAS  Google Scholar 

  130. Lundell I, Blomqvist AG, Berglund MM, Schober DA, Johnson D, Statnick MA, Gadski RA, Gehlert DR, Larhammar D (1995) Cloning of a human receptor of the NPY receptor family with high affinity for pancreatic polypeptide and peptide YY. J Biol Chem 270: 29123–29128

    PubMed  CAS  Google Scholar 

  131. Lundell I, Statnick MA, Johnson D, Schober DA, Starbäck P, Gehlert DR, Larhammar D (1996) The cloned rat pancreatic polypeptide receptor exhibits profound differences to the orthologous human receptor. Proc Natl Acad Sci USA 93: 5111–5115

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2005 Birkhäuser Verlag Basel/Switzerland

About this chapter

Cite this chapter

Larhammar, D., Salaneck, E. (2005). Evolutionary perspective on the NPY-PYY-PP peptides and their receptors. In: Zukowska, Z., Feuerstein, G.Z. (eds) The NPY Family of Peptides in Immune Disorders, Inflammation, Angiogenesis and Cancer. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7427-6_1

Download citation

Publish with us

Policies and ethics