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Introduction

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Chemokine Biology — Basic Research and Clinical Application

Part of the book series: Progress in Inflammation Research ((PIR))

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References

  1. Walz A, Peveri P, Aschauer H, Baggiolini M (1987) Purification and amino acid sequencing of NAF, a novel neutrophil-activating factor produced by monocytes. Biochem Biophys Res Commun 149: 755–761

    Article  CAS  PubMed  Google Scholar 

  2. Yoshimura T, Matsushima K, Tanaka S, Robinson EA, Appella E, Oppenheim JJ, Leonard EJ (1987) Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines. Proc Natl Acad Sci USA 84: 9233–9237

    CAS  PubMed  Google Scholar 

  3. Schröder J-M, Mrowietz U, Morita E, Christophers E (1987) Purification and partial biochemical characterization of a human monocyte-derived, neutrophil-activating peptide that lacks interleukin 1 activity. J Immunol 139: 3474–3483

    PubMed  Google Scholar 

  4. Van Damme J, Van Beeumen J, Opdenakker G, Billiau A (1988) A novel, NH2-terminal sequence-characterized human monokine possessing neutrophil chemotactic, skin-reactive, and granulocytosis-promoting activity. J Exp Med 167: 1364–1376

    PubMed  Google Scholar 

  5. Thelen M, Peveri P, Kernen P, von Tscharner V, Walz A, Baggiolini M (1988) Mechanism of neutrophil activation by NAF, a novel monocyte-derived peptide agonist. FASEB J 2: 2702–2706

    CAS  PubMed  Google Scholar 

  6. Baggiolini M, Walz A, Kunkel SL (1989) Neutrophil-activating peptide-1/interleukin 8, a novel cytokine that activates neutrophils. J Clin Invest 84: 1045–1049

    CAS  PubMed  Google Scholar 

  7. Lindley I, Aschauer H, Seifert JM, Lam C, Brunowsky W, Kownatzki E, Thelen M, Peveri P, Dewald B, von Tscharner V et al (1988) Synthesis and expression in Escherichia coli of the gene encoding monocyte-derived neutrophil-activating factor: Biological equivalence between natural and recombinant neutrophil-activating factor. Proc Natl Acad Sci USA 85: 9199–9203

    CAS  PubMed  Google Scholar 

  8. Clark-Lewis I, Moser B, Walz A, Baggiolini M, Scott GJ, Aebersold R (1991) Chemical synthesis, purification, and characterization of two inflammatory proteins, neutrophil activating peptide 1 (interleukin-8) and neutrophil activating peptide 2. Biochemistry 30: 3128–3135

    Article  CAS  PubMed  Google Scholar 

  9. Baggiolini M (2001) Chemokines in pathology and medicine. J Intern Med 250: 91–104

    Article  CAS  PubMed  Google Scholar 

  10. Murphy PM (2001) Viral exploitation and subversion of the immune system through chemokine mimicry. Nat Immunol 2: 116–122

    Article  CAS  PubMed  Google Scholar 

  11. Baggiolini M, Dewald B, Moser B (1994) Interleukin-8 and related chemotactic cytokines — CXC and CC chemokines. Adv Immunol 55: 97–179

    CAS  PubMed  Google Scholar 

  12. Baggiolini M, Dewald B, Moser B (1997) Human chemokines: An update. Annu Rev Immunol 15: 675–705

    Article  CAS  PubMed  Google Scholar 

  13. Clark-Lewis I, Kim K-S, Rajarathnam K, Gong J-H, Dewald B, Moser B, Baggiolini M, Sykes BD (1995) Structure-activity relationships of chemokines. J Leukocyte Biol 57: 703–711

    CAS  PubMed  Google Scholar 

  14. Kelner GS, Kennedy J, Bacon KB, Kleyensteuber S, Largaespada DA, Jenkins NA, Copeland NG, Bazan JF, Moore KW, Schall TJ et al (1994) Lymphotactin: A cytokine that represents a new class of chemokine. Science 266: 1395–1399

    CAS  PubMed  Google Scholar 

  15. Kennedy J, Kelner GS, Kleyensteuber S, Schall TJ, Weiss MC, Yssel H, Schneider PV, Cocks BG, Bacon KB, Zlotnik A (1995) Molecular cloning and functional characterization of human lymphotactin. J Immunol 155: 203–209

    CAS  PubMed  Google Scholar 

  16. Bazan JF, Bacon KB, Hardiman G, Wang W, Soo K, Rossi D, Greaves DR, Zlotnik A, Schall TJ (1997) A new class of membrane-bound chemokine with a CX3C motif. Nature 385: 640–644

    Article  CAS  PubMed  Google Scholar 

  17. Pan Y, Lloyd C, Zhou H, Dolich S, Deeds J, Gonzalo JA, Vath J, Gosselin M, Ma JY, Dussault B et al (1997) Neurotactin, a membrane-anchored chemokine upregulated in brain inflammation. Nature 387: 611–617

    Article  CAS  PubMed  Google Scholar 

  18. Matloubian M, David A, Engel S, Ryan JE, Cyster JG (2000) A transmembrane CXC chemokine is a ligand for HIV-coreceptor Bonzo. Nat Immunol 1: 298–304

    Article  CAS  PubMed  Google Scholar 

  19. Imai T, Hieshima K, Haskell C, Baba M, Nagira M, Nishimura M, Kakizaki M, Takagi S, Nomiyama H, Schall TJ et al (1997) Identification and molecular characterization of fractalkine receptor CX3CR1, which mediates both leukocyte migration and adhesion. Cell 91: 521–530

    Article  CAS  PubMed  Google Scholar 

  20. Fong AM, Robinson LA, Steeber DA, Tedder TF, Yoshie O, Imai T, Patel DD (1998) Fractalkine and CX3CR1 mediate a novel mechanism of leukocyte capture, firm adhesion, and activation under physiologic flow. J Exp Med 188: 1413–1419

    Article  CAS  PubMed  Google Scholar 

  21. Murphy PM, Baggiolini M, Charo IF, Hebert CA, Horuk R, Matsushima K, Miller LH, Oppenheim JJ, Power CA (2000) International union of pharmacology. XXII. Nomenclature for chemokine receptors. Pharmacol Rev 52: 145–176

    CAS  PubMed  Google Scholar 

  22. Thelen M (2001) Dancing to the tune of chemokines. Nat Immunol 2: 129–134

    Article  CAS  PubMed  Google Scholar 

  23. Chakravarty L, Rogers L, Quach T, Breckenridge S, Kolattukudy PE (1998) Lysine 58 and histidine 66 at the C-terminal α-helix of monocyte chemoattractant protein-1 are essential for glycosaminoglycan binding. J Biol Chem 273: 29641–29647

    Article  CAS  PubMed  Google Scholar 

  24. Amara A, Lorthioir O, Valenzuela A, Magerus A, Thelen M, Montes M, Virelizier JL, Delepierre M, Baleux F, Lortat-Jacob H et al (1999) Stromal cell-derived factor-1a associates with heparan sulfates through the first b-strand of the chemokine. J Biol Chem 274: 23916–23925

    Article  CAS  PubMed  Google Scholar 

  25. Webb LMC, Ehrengruber MU, Clark-Lewis I, Baggiolini M, Rot A (1993) Binding to heparan sulfate or heparin enhances neutrophil responses to interleukin 8. Proc Natl Acad Sci USA 90: 7158–7162

    CAS  PubMed  Google Scholar 

  26. Middleton J, Neil S, Wintle J, Clark-Lewis I, Moore H, Lam C, Auer M, Hub E, Rot A (1997) Transcytosis and surface presentation of IL-8 ky venular endothelial cells. Cell 91: 385–395

    Article  CAS  PubMed  Google Scholar 

  27. Baggiolini M, Dahinden CA (1994) CC chemokines in allergic inflammation. Immunol Today 15: 127–133

    Article  CAS  PubMed  Google Scholar 

  28. Loetscher P, Seitz M, Baggiolini M, Moser B (1996) Interleukin-2 regulates CC chemokine receptor expression and chemotactic responsiveness in T lymphocytes. J Exp Med 184: 569–577

    CAS  PubMed  Google Scholar 

  29. Bonecchi R, Bianchi G, Bordignon PP, D’Ambrosio D, Lang R, Borsatti A, Sozzani S, Allavena P, Gray PA, Mantovani A et al (1998) Differential expression of chemokine receptors and chemotactic responsiveness of type 1 T helper cells (Th1s) and Th2s. J Exp Med 187: 129–134

    Article  CAS  PubMed  Google Scholar 

  30. Sallusto F, Lenig D, Mackay CR, Lanzavecchia A (1998) Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J Exp Med 187: 875–883

    Article  CAS  PubMed  Google Scholar 

  31. Loetscher P, Moser B, Baggiolini M (2000) Chemokines and their receptors in lymphocyte traffic and HIV infection. Adv Immunol 74: 127–180

    CAS  PubMed  Google Scholar 

  32. Sallusto F, Mackay CR, Lanzavecchia A (2000) The role of chemokine receptors in primary, effector, and memory immune responses. Annu Rev Immunol 18: 593–620

    Article  CAS  PubMed  Google Scholar 

  33. Sallusto F, Geginat J, Lanzavecchia A (2004) Central memory and effector memory T cell subsets: function, generation, and maintenance. Annu Rev Immunol 22: 745–763

    Article  CAS  PubMed  Google Scholar 

  34. Moser B, Loetscher P (2001) Lymphocyte traffic control by chemokines. Nat Immunol 2: 123–128

    CAS  PubMed  Google Scholar 

  35. Moser B, Wolf M, Walz A, Loetscher P (2004) Chemokines: multiple levels of leukocyte migration control. Trends Immunol 25: 75–84

    Article  CAS  PubMed  Google Scholar 

  36. Förster R, Mattis AE, Kremmer E, Wolf E, Brem G, Lipp M (1996) A putative chemokine receptor, BLR1, directs B cell migration to defined lymphoid organs and specific anatomic compartments of the spleen. Cell 87: 1037–1047

    PubMed  Google Scholar 

  37. Legler DF, Loetscher M, Roos RS, Clark-Lewis I, Baggiolini M, Moser B (1998) B cell-attracting chemokine 1, a human CXC chemokine expressed in lymphoid tissues, selectively attracts B lymphocytes via BLR1/CXCR5. J Exp Med 187: 655–660

    Article  CAS  PubMed  Google Scholar 

  38. Gunn MD, Ngo VN, Ansel KM, Ekland EH, Cyster JG, Williams LT (1998) A B-cellhoming chemokine made in lymphoid follicles activates Burkitt’s lymphoma receptor-1. Nature 391: 799–803

    CAS  PubMed  Google Scholar 

  39. Förster R, Schubel A, Breitfeld D, Kremmer E, Renner-Müller I, Wolf E, Lipp M (1999) CCR7 coordinates the primary immune response by establishing functional microenvironments in secondary lymphoid organs. Cell 99: 23–33

    PubMed  Google Scholar 

  40. Schaerli P, Willimann K, Lang AB, Lipp M, Loetscher P, Moser B (2000) CXC chemokine receptor 5 expression defines follicular homing T cells with B cell helper function. J Exp Med 192: 1553–1562

    Article  CAS  PubMed  Google Scholar 

  41. Breitfeld D, Ohl L, Kremmer E, Ellwart J, Sallusto F, Lipp M, Forster R (2000) Follicular B helper T cells express CXC chemokine receptor 5, localize to B cell follicles, and support immunoglobulin production. J Exp Med 192: 1545–1552

    Article  CAS  PubMed  Google Scholar 

  42. Moser B, Schaerli P, Loetscher P (2002) CXCR5(+) T cells: follicular homing takes center stage in T-helper-cell responses. Trends Immunol 23: 250–254

    Article  CAS  PubMed  Google Scholar 

  43. Schaerli P, Ebert L, Willimann K, Blaser A, Roos RS, Loetscher P, Moser B (2004) A skin-selective homing mechanism for human immune surveillance T cells. J Exp Med 199: 1265–1275

    Article  CAS  PubMed  Google Scholar 

  44. Ebert LM, Schaerli P, Moser B (2005) Chemokine-mediated control of T cell traffic in lymphoid and peripheral tissues. Mol Immunol 42: 799–809

    Article  CAS  PubMed  Google Scholar 

  45. Svensson M, Marsal J, Ericsson A, Carramolino L, Broden T, Marquez G, Agace WW (2002) CCL25 mediates the localization of recently activated CD8alphabeta(+) lymphocytes to the small-intestinal mucosa. J Clin Invest 110: 1113–1121

    Article  CAS  PubMed  Google Scholar 

  46. Johansson-Lindbom B, Svensson M, Wurbel MA, Malissen B, Marquez G, Agace W (2003) Selective generation of gut tropic T cells in gut-associated lymphoid tissue (GALT): requirement for GALT dendritic cells and adjuvant. J Exp Med 198: 963–969

    Article  CAS  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Università della Svizzera Italiana, Via Lambertenghi 10A, 6904, Lugano, Switzerland

    Marco Baggiolini

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  1. Marco Baggiolini
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Editor information

Editors and Affiliations

  1. Institute of Cell Biology, University of Bern, Baltzerstrasse 4, 3012, Bern, Switzerland

    Bernhard Moser

  2. NitroMed, Inc., 12 Oak Park Drive, Bedford, MA, 01730, USA

    Gordon L. Letts

  3. Bone and Inflammation, Eli Lilly and Company Lilly Corporate Center, Indianapolis, IN, 46285, USA

    Kuldeep Neote

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© 2006 Birkhäuser Verlag Basel/Switzerland

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Baggiolini, M. (2006). Introduction. In: Moser, B., Letts, G.L., Neote, K. (eds) Chemokine Biology — Basic Research and Clinical Application. Progress in Inflammation Research. Birkhäuser Basel. https://doi.org/10.1007/3-7643-7423-3_1

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